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dc.contributor.authorKjaer S.K.en
dc.contributor.authorBandera E.V.en
dc.contributor.authorCook L.S.en
dc.contributor.authorCramer D.W.en
dc.contributor.authorMilne R.L.en
dc.contributor.authorWinham S.J.en
dc.contributor.authorModugno F.en
dc.contributor.authorMukherjee B.en
dc.contributor.authorPearce C.L.en
dc.contributor.authorPharoah P.D.P.en
dc.contributor.authorPike M.C.en
dc.contributor.authorHuntsman D.en
dc.contributor.authorHogdall E.en
dc.contributor.authorTrabert B.en
dc.contributor.authorWentzensen N.en
dc.contributor.authorLe N.D.en
dc.contributor.authorSchildkraut J.M.en
dc.contributor.authorHarris H.R.en
dc.contributor.authorChang-Claude J.en
dc.contributor.authorThompson P.J.en
dc.contributor.authorKim S.en
dc.contributor.authorWang M.en
dc.contributor.authorTyrer J.P.en
dc.contributor.authorJensen A.en
dc.contributor.authorWiensch A.en
dc.contributor.authorLiu G.en
dc.contributor.authorLee A.W.en
dc.contributor.authorNess R.B.en
dc.contributor.authorSalvatore M.en
dc.contributor.authorTworoger S.S.en
dc.contributor.authorWhittemore A.S.en
dc.contributor.authorAnton-Culver H.en
dc.contributor.authorSieh W.en
dc.contributor.authorOlson S.H.en
dc.contributor.authorBerchuck A.en
dc.contributor.authorGoode E.L.en
dc.contributor.authorGoodman M.T.en
dc.contributor.authorDoherty J.A.en
dc.contributor.authorChenevix-Trench G.en
dc.contributor.authorRossing M.A.en
dc.contributor.authorWebb P.M.en
dc.contributor.authorGiles G.G.en
dc.contributor.authorTerry K.L.en
dc.contributor.authorZiogas A.en
dc.contributor.authorFortner R.T.en
dc.contributor.authorMenon U.en
dc.contributor.authorGayther S.A.en
dc.contributor.authorWu A.H.en
dc.contributor.authorSong H.en
dc.contributor.authorBrooks-Wilson A.en
dc.date.accessioned2021-05-14T12:13:36Zen
dc.date.available2021-05-14T12:13:36Zen
dc.date.copyright2019en
dc.date.created20190327en
dc.date.issued2019-03-27en
dc.identifier.citationInternational Journal of Cancer. 144 (9) (pp 2192-2205), 2019. Date of Publication: 01 May 2019.en
dc.identifier.issn0020-7136en
dc.identifier.urihttps://repository.monashhealth.org/monashhealthjspui/handle/1/36083en
dc.description.abstractAs a follow-up to genome-wide association analysis of common variants associated with ovarian carcinoma (cancer), our study considers seven well-known ovarian cancer risk factors and their interactions with 28 genome-wide significant common genetic variants. The interaction analyses were based on data from 9971 ovarian cancer cases and 15,566 controls from 17 case-control studies. Likelihood ratio and Wald tests for multiplicative interaction and for relative excess risk due to additive interaction were used. The top multiplicative interaction was noted between oral contraceptive pill (OCP) use (ever vs. never) and rs13255292 (p value = 3.48 x 10-4). Among women with the TT genotype for this variant, the odds ratio for OCP use was 0.53 (95% CI = 0.46-0.60) compared to 0.71 (95%CI = 0.66-0.77) for women with the CC genotype. When stratified by duration of OCP use, women with 1-5 years of OCP use exhibited differential protective benefit across genotypes. However, no interaction on either the multiplicative or additive scale was found to be statistically significant after multiple testing correction. The results suggest that OCP use may offer increased benefit for women who are carriers of the T allele in rs13255292. On the other hand, for women carrying the C allele in this variant, longer (5+ years) use of OCP may reduce the impact of carrying the risk allele of this SNP. Replication of this finding is needed. The study presents a comprehensive analytic framework for conducting gene-environment analysis in ovarian cancer.Copyright © 2018 UICCen
dc.languageEnglishen
dc.languageenen
dc.publisherWiley-Liss Inc. (E-mail: info@wiley.com)en
dc.relation.ispartofInternational Journal of Canceren
dc.titleA comprehensive gene-environment interaction analysis in Ovarian Cancer using genome-wide significant common variants.en
dc.typeArticleen
dc.identifier.doihttp://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1002/ijc.32029en
dc.publisher.placeUnited Statesen
dc.identifier.pubmedid30499236 [http://www.ncbi.nlm.nih.gov/pubmed/?term=30499236]en
dc.identifier.source626066930en
dc.identifier.institution(Kim, Wang, Salvatore, Mukherjee) Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, United States (Tyrer, Song, Pharoah) Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom (Jensen, Kjaer, Hogdall) Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark (Wiensch, Salvatore, Pearce) Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, United States (Liu) Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, United States (Lee) Department of Public Health, California State University, Fullerton, Fullerton, CA, United States (Ness) University of Texas School of Public Health, Houston, TX, United States (Tworoger) Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, United States (Tworoger, Terry, Cramer) Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, United States (Whittemore) Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA, United States (Whittemore) Department of Biomedical Data Science, Stanford University School of Medicine, Stanford, CA, United States (Anton-Culver, Ziogas) Department of Epidemiology, Genetic Epidemiology Research Institute, University of California Irvine, Irvine, CA, United States (Sieh) Department of Genetics and Genomic Sciences, Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, United States (Olson, Pike) Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY, United States (Berchuck) Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC, United States (Goode, Winham) Department of Health Sciences Research, Mayo Clinic, Rochester, MN, United States (Goodman, Thompson) Cancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States (Goodman) Department of Biomedical Sciences, Cedars-Sinai Medical Center, Community and Population Health Research Institute, Los Angeles, CA, United States (Doherty) Department of Population Health Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, United States (Chenevix-Trench) Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia (Rossing, Harris) Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, United States (Rossing) Department of Epidemiology, University of Washington, Seattle, WA, United States (Webb) Population Health Department, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia (Giles, Milne) Cancer Epidemiology & Intelligence Division, Cancer Council Victoria, Melbourne, VIC, Australia (Giles, Milne) Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia (Giles) Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, VIC, Australia (Terry, Cramer) Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital, Boston, MA, United States (Fortner, Chang-Claude) Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (Menon) Gynaecological Cancer Research Centre, Women's Cancer, Institute for Women's Health, University College London, London, United Kingdom (Gayther, Wu) Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States (Gayther, Pearce) Center for Cancer Prevention and Translational Genomics, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States (Gayther) Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, United States (Brooks-Wilson) Genome Sciences Centre, BC Cancer Agency, Vancouver, BC, Canada (Brooks-Wilson) Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, Canada (Bandera) Cancer Prevention and Control Program, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, United States (Cook) University of New Mexico Health Sciences Center, University of New Mexico, Albuquerque, NM, United States (Cook) Division of Cancer Care, Department of Population Health Research, Alberta Health Services, Calgary, AB, Canada (Milne) Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia (Kjaer) Department of Gynaecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark (Modugno) Ovarian Cancer Center of Excellence, Womens Cancer Research Program, Magee-Womens Research Institute and Hillman Cancer Center, Pittsburgh, PA, United States (Modugno) Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, United States (Modugno) Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States (Chang-Claude) Cancer Epidemiology Group, University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Schildkraut) Department of Public Health Sciences, University of Virginia, Charlottesville, VA, United States (Le) Cancer Control Research, BC Cancer Agency, Vancouver, BC, Canada (Wentzensen, Trabert) Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States (Hogdall) Molecular Unit, Department of Pathology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark (Huntsman) British Columbia's Ovarian Cancer Research (OVCARE) program, Vancouver General Hospital, BC Cancer and University of British Columbia, Canada (Huntsman) Department of Pathology and Laboratory Medicine, and Obstetrics and Gynecology, University of British Columbia, Vancouver, BC, Canada (Pike) Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, United States (Pharoah) Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdomen
dc.description.addressB. Mukherjee, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, United States. E-mail: bhramar@umich.eduen
dc.description.publicationstatusEmbaseen
dc.rights.statementCopyright 2019 Elsevier B.V., All rights reserved.en
dc.subect.keywordsadditive interaction G x E genetics ovarian canceren
dc.identifier.authoremailMukherjee B.; bhramar@umich.eduen
dc.description.grantNo: 1043134 Organization: *National Health and Medical Research Council* Organization No: 501100000925 Country: Australia No: MOP-86727 Organization: *Canadian Institutes of Health Research* Organization No: 501100000024 Country: Canada Organization: (CINJ) *Rutgers Cancer Institute of New Jersey* Organization No: 100007558 Country: United States Organization: (DKFZ) *Deutsches Krebsforschungszentrum* Organization No: 100008658 Country: Germany No: 94 222 52 Organization: *Kraeftens Bekaempelse* Organization No: 100008363 Country: Denmark Organization: (MFMER) *Mayo Foundation for Medical Education and Research* Organization No: 100007048 Country: United States No: DAMD17-01-1-0729 Organization: *Medical Research and Materiel Command* Organization No: 100000182 Country: United States Organization: *Minnesota Ovarian Cancer Alliance* Organization No: 100003135 Country: United States No: 1 R01CA160669-01A1 Organization: *National Cancer Institute* Organization No: 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