Please use this identifier to cite or link to this item: https://repository.monashhealth.org/monashhealthjspui/handle/1/36142
Title: Cognitive outcomes of childhood primary cns vasculitis.
Authors: Kirton A.;Benseler S.M.;Brooks B.L.;Gowdie P. ;Sheikh S.;Deschamps K.;Yeates K.O.;Fay-McClymont T.B.;Twilt M.;Westmacott R.;Dropol A.
Institution: (Deschamps) Department of Psychology, University of Calgar., Canada (Yeates) Department of Psychology, Alberta Children's Hospital Research Institute, Canada (Yeates, Kirton) Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Canada (Fay-McClymont) Neurosciences Program, Alberta Children's Hospital, Calgary, AB, Canada (Fay-McClymont, Dropol) Department of Pediatrics, Cumming School of Medicine, University of Calgary, Alberta Children's Hospital Research Institute, Canada (Twilt, Dropol) Section of Rheumatology, Department of Pediatrics, Alberta Children's Hospital, Canada (Twilt, Brooks) Alberta Children's Hospital Research Institute, Department of Pediatrics, Department of Clinical Neurosciences, Cumming School of Medicine, Department of Psychology, University of Calgary, Canada (Westmacott) Psychology Department, Hospital for Sick Children, Toronto, ON, Canada (Westmacott) Department of Pediatrics, Faculty of Medicine, University of Toronto, Canada (Brooks) Neurosciences Program, Alberta Children's Hospital, Canada (Kirton) Departments of Pediatrics and Clinical Neurosciences, Alberta Children's Hospital Research Institute, Canada (Gowdie) Rheumatology Service, Department of General Medicine, Royal Children's Hospital, Melbourne, VIC, Australia (Gowdie) Department of Pediatric Rheumatology, Monash Children's Hospital, Melbourne, VIC, Australia (Gowdie) Department of Pediatrics, Monash University, Australia (Sheikh) Information Services, Hospital for Sick Children, Canada (Benseler) Alberta Children's Hospital Research Institute, Department of Pediatrics, Cumming School of Medicine, University of Calgary, Canada (Dropol, Benseler) University of British Columbia, BC Children's Hospital Research Institute, Vancouver, BC, Canada
Issue Date: 21-May-2019
Copyright year: 2019
Publisher: American Psychological Association Inc. (E-mail: journals@apa.org)
Place of publication: United States
Publication information: Neuropsychology. 33 (4) (pp 462-469), 2019. Date of Publication: May 2019.
Journal: Neuropsychology
Abstract: Objective: To characterize the clinical cognitive phenotypes and severity of cognitive burden according to disease subtype in children with primary central nervous system vasculitis (cPACNS). Method(s): This retrospective multicenter inflammatory brain disease database study examined the neuropsychological outcomes of 80 children (44 male; mean age - 7.89 years, SD = 4.17) consecutively diagnosed with primary CNS vasculitis between 1992 and 2016. Twenty-one children had small-vessel disease (AN=cPACNS), and 59 had large-vessel disease (including 49 nonprogressive [APNP-cPACNS] and 10 progressive [APP-cPACNS]). Neuroimaging revealed MRI abnormalities in 100% and 90% of children with large-and small-vessel vasculitis, respectively. The primary outcomes were Full Scale IQ (FSIQ) and the index scores from the Wechsler Intelligence Scale for Children-III (WISC-III, WISC-IV, and WISC-V). Analyses explored the effect of disease subtype. Result(s): Intellectual functioning was assessed on average 2.82 years after symptom onset. Children with small-vessel CNS vasculitis had significantly lower FSIQ scores than did those with large-vessel CNS vasculitis (Ms - 81.90 vs. 94.82; p - .04). Intellectual disability (FSIQ - 70) was more frequent in children with small-vessel disease (24% vs. 5%). All groups displayed lower Working Memory and Processing Speed index scores relative to Verbal Comprehension and Perceptual Reasoning index scores. Group differences in FSIQ remained significant after controlling for the presence of seizures. Conclusion(s): Children with small-vessel CNS vasculitis are more likely to demonstrate deficits in intellectual functioning than are those with large-vessel disease, and children with both types of CNS vasculitis demonstrate relatively poor working memory and processing speed.Copyright © 2019 American Psychological Association.
DOI: http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1037/neu0000513
PubMed URL: 30762375 [http://www.ncbi.nlm.nih.gov/pubmed/?term=30762375]
ISSN: 0894-4105
URI: https://repository.monashhealth.org/monashhealthjspui/handle/1/36142
Type: Article
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