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Please use this identifier to cite or link to this item: https://repository.monashhealth.org/monashhealthjspui/handle/1/36203
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dc.contributor.authorSehgal A.en
dc.contributor.authorDahlstrom J.E.en
dc.contributor.authorMurthi P.en
dc.date.accessioned2021-05-14T12:16:20Zen
dc.date.available2021-05-14T12:16:20Zen
dc.date.copyright2019en
dc.date.created20190305en
dc.date.issued2019-03-05-
dc.date.issued2019-03-05en
dc.identifier.citationJournal of Perinatology. 39 (3) (pp 366-374), 2019. Date of Publication: 01 Mar 2019.en
dc.identifier.issn0743-8346en
dc.identifier.urihttps://repository.monashhealth.org/monashhealthjspui/handle/1/36203en
dc.description.abstractFetal growth restriction (FGR) affects about 5-10% pregnancies and is associated with poorer outcomes in the perinatal period. Additionally, long standing epidemiological data support its association with chronic diseases such as hypertension and diabetes. Cardiac and vascular adaptations in response to chronic hypoxemia due to utero-placental insufficiency are hallmarks of fetal adaptations. Investigators have attempted to identify these changes in the placenta at the microscopic and molecular level. The ex vivo dual perfusion model of the placenta enables the study of placental haemodynamics in growth-restricted pregnancies. Persistent arterial abnormalities (thickness and stiffness) noted on vascular ultrasound during fetal life through to the young-adult age group for those affected by FGR, seem to be a plausible link between in utero events and chronic circulatory diseases. Using these, this review reflects current thought on vascular maladaptive changes in the FGR cohorts and the role in investigating current and future therapeutics.Copyright © 2018, Springer Nature America, Inc.en
dc.languageEnglishen
dc.languageenen
dc.publisherNature Publishing Group (Houndmills, Basingstoke, Hampshire RG21 6XS, United Kingdom)en
dc.relation.ispartofJournal of Perinatologyen
dc.titleVascular changes in fetal growth restriction: clinical relevance and future therapeutics.en
dc.typeReviewen
dc.type.studyortrialReview article (e.g. literature review, narrative review)-
dc.identifier.doihttp://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1038/s41372-018-0287-4en
dc.publisher.placeUnited Kingdomen
dc.identifier.pubmedid30518801 [http://www.ncbi.nlm.nih.gov/pubmed/?term=30518801]en
dc.identifier.source625381031en
dc.identifier.institution(Sehgal) Monash Newborn, Monash Children's Hospital, Monash University, Melbourne, Australia (Sehgal) Department of Pediatrics, Monash University, Melbourne, Australia (Murthi) Department of Maternal Fetal Medicine, Pregnancy Research Centre, Royal Women's Hospital and Department of Obstetrics and Gynaecology, The University of Melbourne, Parkville, VIC, Australia (Murthi) Department of Physiology, Monash University and The Ritchie Centre, Hudson Institute of Medical Research, Clayton, VIC, Australia (Dahlstrom) Anatomical Pathology, ACT Pathology, The Canberra Hospital and the Australian National University Medical School, College of Health and Medicine, Canberra, ACT, Australiaen
dc.description.addressA. Sehgal, Monash Newborn, Monash Children's Hospital, Monash University, Melbourne, Australia. E-mail: Arvind.Sehgal@monash.eduen
dc.description.publicationstatusEmbaseen
dc.rights.statementCopyright 2019 Elsevier B.V., All rights reserved.en
dc.identifier.authoremailSehgal A.; Arvind.Sehgal@monash.eduen
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.openairetypeReview-
crisitem.author.deptPaediatric - Neonatal (Monash Newborn)-
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