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Please use this identifier to cite or link to this item: https://repository.monashhealth.org/monashhealthjspui/handle/1/36214
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dc.contributor.authorTaylor A.J.en
dc.contributor.authorCostello B.T.en
dc.contributor.authorStub D.en
dc.contributor.authorHare J.en
dc.contributor.authorEllims A.H.en
dc.contributor.authorWang X.en
dc.contributor.authorKaye D.M.en
dc.contributor.authorIles L.en
dc.contributor.authorSmith K.en
dc.contributor.authorBernard S.en
dc.contributor.authorNehme Z.en
dc.contributor.authorStephenson M.en
dc.contributor.authorBray J.E.en
dc.contributor.authorCameron P.en
dc.contributor.authorBarger B.en
dc.contributor.authorMeredith I.T.en
dc.date.accessioned2021-05-14T12:16:33Zen
dc.date.available2021-05-14T12:16:33Zen
dc.date.copyright2019en
dc.date.created20190208en
dc.date.issued2019-02-08en
dc.identifier.citationHeart Lung and Circulation. 28 (3) (pp 397-405), 2019. Date of Publication: March 2019.en
dc.identifier.issn1443-9506en
dc.identifier.urihttps://repository.monashhealth.org/monashhealthjspui/handle/1/36214en
dc.description.abstractBackground: Late gadolinium enhancement (LGE) with cardiac magnetic resonance (CMR) is commonly assumed to represent myocardial fibrosis; however, comparative human histological data are limited, and there is no consensus on the most accurate method for LGE quantitation. We evaluated the relationship between CMR assessment of regional fibrosis and infarct size assessment using serial biomarkers after ST elevation acute myocardial infarction (STEMI). Method(s): Ninety-three patients treated for STEMI (59 +/- 10 years, 86% male) underwent CMR 6 months after infarction. Infarct size was quantified by CMR-LGE using manual and range of semi-automated thresholds (range: 2-10 standard deviations [SD]) above reference myocardium and the full width-half maximum (FWHM) technique, and compared with the rise in serum biomarkers. The agreement between CMR and biomarker in the identification of large infarcts based on peak troponin (TnI) levels was also analysed. Result(s): Quantification methods had a strong influence on the infarct size assessment with CMR-LGE. Significant correlations were observed between LGE and biomarkers across all of the signal intensity thresholds. Whilst there was a wide variation with respect to the estimation of total LGE size (from 6.8 +/- 7.7 to 32.1 +/- 11.3 grams), the variation in the correlation with peak troponin level was much smaller (r-values ranging from 0.670 to 0.876). There was good agreement between CMR-LGE and biomarker assessment of infarct size; the best agreement between CMR-LGE and large infarction using a threshold of 8SD for peak TnI > 50 ng/mL (Cohen's kappa (kappa) = 0.722), and a threshold of 4SD for peak TnI > 95 ng/mL (kappa = 0.761). Conclusion(s): The correlation between CMR-LGE quantification of infarct size and biomarker release following STEMI at a range of semi-automated thresholds was consistently strong, with good agreement between measures across a range of thresholds.Copyright © 2018en
dc.languageEnglishen
dc.languageenen
dc.publisherElsevier Ltden
dc.relation.ispartofHeart Lung and Circulationen
dc.subjectcreatine kinase/ec [Endogenous Compound]en
dc.subjectgadolinium pentetate meglumineen
dc.subjecttroponin I/ec [Endogenous Compound]en
dc.subjectimaging softwareen
dc.subjectnuclear magnetic resonance scanneren
dc.subjectSigna HD 1.5 Ten
dc.subjectheart infarction sizeen
dc.subjectprotein blood levelen
dc.subjectprotein secretionen
dc.subjectadulten
dc.subjectarticleen
dc.subject*cardiovascular magnetic resonanceen
dc.subjectclinical assessmenten
dc.subjectcontrolled studyen
dc.subjectdiagnostic accuracyen
dc.subjectdiagnostic test accuracy studyen
dc.subjectelectrocardiogramen
dc.subjectfemaleen
dc.subjectfollow upen
dc.subjectheart left ventricle ejection fractionen
dc.subject*heart muscle fibrosis/di [Diagnosis]en
dc.subjectheart muscle reperfusionen
dc.subjectheart ventricle functionen
dc.subjecthumanen
dc.subjectintermethod comparisonen
dc.subjectmajor clinical studyen
dc.subjectmaleen
dc.subjectmiddle ageden
dc.subjectpriority journalen
dc.subjectprospective studyen
dc.subjectreceiver operating characteristicen
dc.subjectsensitivity and specificityen
dc.subject*ST segment elevation myocardial infarction/di [Diagnosis]en
dc.subjectthorax painen
dc.subject*biological marker/ec [Endogenous Compound]en
dc.titleComparison of Magnetic Resonance Analysis of Myocardial Scarring With Biomarker Release Following S-T Elevation Myocardial Infarction.en
dc.typeArticleen
dc.identifier.doihttp://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1016/j.hlc.2018.02.007en
dc.publisher.placeUnited Kingdomen
dc.identifier.pubmedid29526416 [http://www.ncbi.nlm.nih.gov/pubmed/?term=29526416]en
dc.identifier.source621086623en
dc.identifier.institution(Costello, Stub, Hare, Ellims, Bernard, Bray, Cameron, Kaye, Iles, Taylor) The Alfred Hospital, Melbourne, Vic, Australia (Costello, Stub, Hare, Ellims, Wang, Kaye, Iles, Taylor) Baker IDI Heart Diabetes Institute, Melbourne, Vic, Australia (Smith, Bernard, Nehme, Stephenson, Barger) Ambulance Victoria, Melbourne, Vic, Australia (Smith, Bernard, Nehme, Stephenson, Bray, Cameron, Meredith, Kaye) Monash University, Melbourne, Vic, Australia (Smith) University of Western Australia, Perth, WA, Australia (Meredith) Monash Medical Centre, Melbourne, Vic, Australia (Stub) Western Health, Melbourne, Vic, Australia (Wang) Peking University Third Hospital, Beijing, Chinaen
dc.description.addressA.J. Taylor, Heart Centre, 3rd Floor Phillip Block, Commercial Road, Melbourne, Victoria 3004, Australia. E-mail: a.taylor@alfred.org.auen
dc.subject.keywordheart infarction sizeen
dc.subject.keywordheart left ventricle ejection fractionen
dc.subject.keyword*heart muscle fibrosis / *diagnosisen
dc.subject.keywordheart muscle reperfusionen
dc.subject.keywordheart ventricle functionen
dc.subject.keywordhumanen
dc.subject.keywordintermethod comparisonen
dc.subject.keywordmajor clinical studyen
dc.subject.keywordmaleen
dc.subject.keywordmiddle ageden
dc.subject.keywordpriority journalen
dc.subject.keywordprospective studyen
dc.subject.keywordprotein blood levelen
dc.subject.keywordprotein secretionen
dc.subject.keywordreceiver operating characteristicen
dc.subject.keywordsensitivity and specificityen
dc.subject.keyword*ST segment elevation myocardial infarction / *diagnosisen
dc.subject.keywordadulten
dc.subject.keywordthorax painen
dc.subject.keywordArticleen
dc.subject.keyword*cardiovascular magnetic resonanceen
dc.subject.keywordclinical assessmenten
dc.subject.keywordcontrolled studyen
dc.subject.keyworddiagnostic accuracyen
dc.subject.keyworddiagnostic test accuracy studyen
dc.subject.keywordelectrocardiogramen
dc.subject.keywordfemaleen
dc.subject.keywordfollow upen
dc.relation.libraryurlLibKey Linken
dc.description.publicationstatusEmbaseen
dc.rights.statementCopyright 2019 Elsevier B.V., All rights reserved.en
dc.subect.keywordsCardiac magnetic resonance Fibrosis Infarct size Late gadolinium enhancementen
dc.identifier.authoremailTaylor A.J.; a.taylor@alfred.org.auen
dc.description.grantOrganization: *Falck Foundation* Organization No: 501100007617 Country: Denmarken
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
crisitem.author.deptCardiology (MonashHeart & Victorian Heart Institute)-
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