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DC Field | Value | Language |
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dc.contributor.author | Shen J. | en |
dc.contributor.author | Gwini S. | en |
dc.contributor.author | Yang J. | en |
dc.contributor.author | Chee N.Y.N. | en |
dc.contributor.author | Fuller P.J. | en |
dc.contributor.author | Choy K.W. | en |
dc.contributor.author | Hashimura H. | en |
dc.contributor.author | Chong W. | en |
dc.contributor.author | Doery J.C.G. | en |
dc.date.accessioned | 2021-05-14T12:32:49Z | en |
dc.date.available | 2021-05-14T12:32:49Z | en |
dc.date.copyright | 2018 | en |
dc.date.created | 20180814 | en |
dc.date.issued | 2018-08-14 | en |
dc.identifier.citation | Clinical Endocrinology. 89 (3) (pp 308-313), 2018. Date of Publication: September 2018. | en |
dc.identifier.issn | 0300-0664 | en |
dc.identifier.uri | https://repository.monashhealth.org/monashhealthjspui/handle/1/36938 | en |
dc.description.abstract | Background: The saline suppression test (SST) serves to confirm the diagnosis of primary aldosteronism (PA) whilst adrenal vein sampling (AVS) is used to determine whether the aldosterone hypersecretion is unilateral or bilateral. An accurate prediction of bilateral PA based on SST results could reduce the need for AVS. Aim(s): We sought to identify SST parameters that reliably predict bilateral PA. Method(s): The results from 121 patients undergoing SSTs at Monash Health from January 2010 to January 2018 including screening blood tests, imaging, AVS and histopathology results were evaluated. Patients were subtyped into unilateral or bilateral PA based on AVS and surgical outcomes. Result(s): Of 113 patients with confirmed PA, 33 had unilateral disease whilst 42 had bilateral disease. In those with bilateral disease, plasma aldosterone concentration (PAC) was significantly lower post-SST, together with a significant fall in the aldosterone-renin ratio (ARR). The combination of PAC < 300 pmol/L and a reduction in ARR post-SST provided 96.8% specificity in predicting bilateral disease. Eighteen of 39 patients (49%) with bilateral PA could have avoided AVS using these criteria. Conclusion(s): A combination of PAC < 300 pmol/L and a lower ARR post-SST could reliably predict bilateral PA. An independent cohort will be needed to validate these findings.Copyright © 2018 John Wiley & Sons Ltd | en |
dc.language | en | en |
dc.language | English | en |
dc.publisher | Blackwell Publishing Ltd | en |
dc.relation.ispartof | Clinical Endocrinology | en |
dc.title | Saline suppression test parameters may predict bilateral subtypes of primary aldosteronism. | en |
dc.type | Article | en |
dc.identifier.doi | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1111/cen.13757 | en |
dc.publisher.place | United Kingdom | en |
dc.identifier.orcid | Hashimura, Hikaru; ORCID: http://orcid.org/0000-0002-6994-8014 Chee, Nicholas Y. N.; ORCID: http://orcid.org/0000-0002-9598-4908 Yang, Jun; ORCID: http://orcid.org/0000-0003-4620-4976 | en |
dc.identifier.pubmedid | 29873811 [http://www.ncbi.nlm.nih.gov/pubmed/?term=29873811] | en |
dc.identifier.source | 623409968 | en |
dc.identifier.institution | (Hashimura, Shen, Fuller, Chee, Yang) Department of Endocrinology, Monash Health, Clayton, VIC, Australia (Shen, Fuller, Yang) Centre for Endocrinology and Metabolism, Hudson Institute of Medical Research, Clayton, VIC, Australia (Doery, Choy) Department of Pathology, Monash Health, Clayton, VIC, Australia (Doery) Department of Medicine, Monash University, Clayton, VIC, Australia (Chong) Department of Imaging, Monash Health, Clayton, VIC, Australia (Gwini) School of Public Health and Preventative Medicine, Monash University, Clayton, VIC, Australia (Gwini) University Hospital Geelong - Barwon Health, Geelong, VIC, Australia (Yang) School of Clinical Sciences, Monash University, Clayton, Vic, Australia | en |
dc.description.address | J. Yang, Department of Endocrinology, Monash Health, Clayton, VIC, Australia. E-mail: jun.yang@hudson.org.au | en |
dc.description.publicationstatus | Embase | en |
dc.rights.statement | Copyright 2019 Elsevier B.V., All rights reserved. | en |
dc.subect.keywords | adrenal adenoma adrenal hyperplasia aldosterone-renin ratio primary aldosteronism saline suppression test | en |
dc.identifier.authoremail | Yang J.; jun.yang@hudson.org.au | en |
item.fulltext | No Fulltext | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | none | - |
item.openairetype | Article | - |
crisitem.author.dept | Endocrinology | - |
crisitem.author.dept | Pathology | - |
Appears in Collections: | Articles |
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