Please use this identifier to cite or link to this item: https://repository.monashhealth.org/monashhealthjspui/handle/1/36938
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dc.contributor.authorShen J.en
dc.contributor.authorGwini S.en
dc.contributor.authorYang J.en
dc.contributor.authorChee N.Y.N.en
dc.contributor.authorFuller P.J.en
dc.contributor.authorChoy K.W.en
dc.contributor.authorHashimura H.en
dc.contributor.authorChong W.en
dc.contributor.authorDoery J.C.G.en
dc.date.accessioned2021-05-14T12:32:49Zen
dc.date.available2021-05-14T12:32:49Zen
dc.date.copyright2018en
dc.date.created20180814en
dc.date.issued2018-08-14en
dc.identifier.citationClinical Endocrinology. 89 (3) (pp 308-313), 2018. Date of Publication: September 2018.en
dc.identifier.issn0300-0664en
dc.identifier.urihttps://repository.monashhealth.org/monashhealthjspui/handle/1/36938en
dc.description.abstractBackground: The saline suppression test (SST) serves to confirm the diagnosis of primary aldosteronism (PA) whilst adrenal vein sampling (AVS) is used to determine whether the aldosterone hypersecretion is unilateral or bilateral. An accurate prediction of bilateral PA based on SST results could reduce the need for AVS. Aim(s): We sought to identify SST parameters that reliably predict bilateral PA. Method(s): The results from 121 patients undergoing SSTs at Monash Health from January 2010 to January 2018 including screening blood tests, imaging, AVS and histopathology results were evaluated. Patients were subtyped into unilateral or bilateral PA based on AVS and surgical outcomes. Result(s): Of 113 patients with confirmed PA, 33 had unilateral disease whilst 42 had bilateral disease. In those with bilateral disease, plasma aldosterone concentration (PAC) was significantly lower post-SST, together with a significant fall in the aldosterone-renin ratio (ARR). The combination of PAC < 300 pmol/L and a reduction in ARR post-SST provided 96.8% specificity in predicting bilateral disease. Eighteen of 39 patients (49%) with bilateral PA could have avoided AVS using these criteria. Conclusion(s): A combination of PAC < 300 pmol/L and a lower ARR post-SST could reliably predict bilateral PA. An independent cohort will be needed to validate these findings.Copyright © 2018 John Wiley & Sons Ltden
dc.languageenen
dc.languageEnglishen
dc.publisherBlackwell Publishing Ltden
dc.relation.ispartofClinical Endocrinologyen
dc.titleSaline suppression test parameters may predict bilateral subtypes of primary aldosteronism.en
dc.typeArticleen
dc.identifier.doihttp://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1111/cen.13757en
dc.publisher.placeUnited Kingdomen
dc.identifier.orcidHashimura, Hikaru; ORCID: http://orcid.org/0000-0002-6994-8014 Chee, Nicholas Y. N.; ORCID: http://orcid.org/0000-0002-9598-4908 Yang, Jun; ORCID: http://orcid.org/0000-0003-4620-4976en
dc.identifier.pubmedid29873811 [http://www.ncbi.nlm.nih.gov/pubmed/?term=29873811]en
dc.identifier.source623409968en
dc.identifier.institution(Hashimura, Shen, Fuller, Chee, Yang) Department of Endocrinology, Monash Health, Clayton, VIC, Australia (Shen, Fuller, Yang) Centre for Endocrinology and Metabolism, Hudson Institute of Medical Research, Clayton, VIC, Australia (Doery, Choy) Department of Pathology, Monash Health, Clayton, VIC, Australia (Doery) Department of Medicine, Monash University, Clayton, VIC, Australia (Chong) Department of Imaging, Monash Health, Clayton, VIC, Australia (Gwini) School of Public Health and Preventative Medicine, Monash University, Clayton, VIC, Australia (Gwini) University Hospital Geelong - Barwon Health, Geelong, VIC, Australia (Yang) School of Clinical Sciences, Monash University, Clayton, Vic, Australiaen
dc.description.addressJ. Yang, Department of Endocrinology, Monash Health, Clayton, VIC, Australia. E-mail: jun.yang@hudson.org.auen
dc.description.publicationstatusEmbaseen
dc.rights.statementCopyright 2019 Elsevier B.V., All rights reserved.en
dc.subect.keywordsadrenal adenoma adrenal hyperplasia aldosterone-renin ratio primary aldosteronism saline suppression testen
dc.identifier.authoremailYang J.; jun.yang@hudson.org.auen
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.openairetypeArticle-
crisitem.author.deptEndocrinology-
crisitem.author.deptPathology-
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