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Please use this identifier to cite or link to this item: https://repository.monashhealth.org/monashhealthjspui/handle/1/36961
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dc.contributor.authorRusso F.M.en
dc.contributor.authorPolglase G.en
dc.contributor.authorDeprest J.en
dc.contributor.authorHodges R.en
dc.contributor.authorHooper S.en
dc.contributor.authorKashyap A.en
dc.contributor.authorDekoninck P.en
dc.contributor.authorCrossley K.en
dc.contributor.authorThio M.en
dc.date.accessioned2021-05-14T12:33:20Zen
dc.date.available2021-05-14T12:33:20Zen
dc.date.copyright2018en
dc.date.created20180723en
dc.date.issued2018-07-23en
dc.identifier.citationAmerican Journal of Perinatology. 35 (9) (pp 823-836), 2018. Date of Publication: 01 Jul 2018.en
dc.identifier.issn0735-1631en
dc.identifier.urihttps://repository.monashhealth.org/monashhealthjspui/handle/1/36961en
dc.description.abstractCongenital diaphragmatic hernia (CDH) is a birth defect characterized by failed closure of the diaphragm, allowing abdominal viscera to herniate into the thoracic cavity and subsequently impair pulmonary and vascular development. Despite improving standardized postnatal management, there remains a population of severe CDH for whom postnatal care falls short. In these severe cases, antenatal surgical intervention (fetoscopic endoluminal tracheal occlusion [FETO]) may improve survival; however, FETO increases the risk of preterm delivery, is not widely offered, and still fails in half of cases. Antenatal medical therapies that stimulate antenatal pulmonary development are therefore interesting alternatives. By presenting the animal research underpinning novel antenatal medical therapies for CDH, and considering the applications of these therapies to clinical practice, this review will explore the future of antenatal CDH management with a focus on the phosphodiesterase-5 inhibitor sildenafil.Copyright © 2018 by Thieme Medical Publishers, Inc.en
dc.languageEnglishen
dc.languageenen
dc.publisherThieme Medical Publishers, Inc. (E-mail: custserv@thieme.com)en
dc.relation.ispartofAmerican Journal of Perinatologyen
dc.titleAntenatal Medical Therapies to Improve Lung Development in Congenital Diaphragmatic Hernia.en
dc.typeReviewen
dc.type.studyortrialReview article (e.g. literature review, narrative review)-
dc.identifier.doihttp://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1055/s-0037-1618603en
dc.publisher.placeUnited Statesen
dc.identifier.pubmedid29341044 [http://www.ncbi.nlm.nih.gov/pubmed/?term=29341044]en
dc.identifier.source620319090en
dc.identifier.institution(Kashyap, Dekoninck, Crossley, Polglase, Hooper, Hodges) Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Australia (Kashyap, Dekoninck, Crossley, Polglase, Hooper, Hodges) Department of Obstetrics and Gynaecology, Monash University, Melbourne, Australia (Thio) Newborn Research Centre, Royal Women's Hospital, Melbourne, Australia (Thio) Centre of Research Excellence in Newborn Medicine, Murdoch Children's Research Institute, Melbourne, Australia (Thio) Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, Australia (Thio) PIPER - Neonatal Retrieval Services Victoria, Royal Children's Hospital, Melbourne, Australia (Russo, Deprest) Division of Woman and Child, Department of Obstetrics and Gynaecology, University Hospitals Leuven, Leuven, Belgium (Russo, Deprest) Department of Development and Regeneration, Cluster Woman and Child, Faculty of Medicine, KU Leuven, Belgium (Deprest) Institute for Women's Health, University College London Hospital, London, United Kingdom (Hodges) Monash Women's Service, Monash Health, Melbourne, Australiaen
dc.description.addressR. Hodges, Monash Medical Centre, 246 Clayton Road, Clayton, VIC 3168, Australia. E-mail: Ryan.Hodges@monash.eduen
dc.description.publicationstatusEmbaseen
dc.rights.statementCopyright 2019 Elsevier B.V., All rights reserved.en
dc.subect.keywordsantenatal therapy congenital diaphragmatic hernia fetal pulmonary hypertension of the newborn pulmonary hypoplasia sildenafilen
dc.identifier.authoremailHodges R.; Ryan.Hodges@monash.eduen
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.openairetypeReview-
item.fulltextNo Fulltext-
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