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DC Field | Value | Language |
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dc.contributor.author | Lightfoot P.A. | en |
dc.contributor.author | Scheffer I.E. | en |
dc.contributor.author | Myers K.A. | en |
dc.contributor.author | Davey M.J. | en |
dc.contributor.author | Ching M. | en |
dc.contributor.author | Ellis C. | en |
dc.contributor.author | Grinton B.E. | en |
dc.contributor.author | Roten A. | en |
dc.date.accessioned | 2021-05-14T12:38:11Z | en |
dc.date.available | 2021-05-14T12:38:11Z | en |
dc.date.copyright | 2018 | en |
dc.date.created | 20181029 | en |
dc.date.issued | 2018-10-29 | en |
dc.identifier.citation | Journal of Clinical Sleep Medicine. 14 (10) (pp 1697-1704), 2018. Date of Publication: 15 Oct 2018. | en |
dc.identifier.issn | 1550-9389 | en |
dc.identifier.uri | https://repository.monashhealth.org/monashhealthjspui/handle/1/37170 | en |
dc.description.abstract | Study Objectives: Dravet syndrome is a severe developmental and epileptic encephalopathy, in which 75% of patients have sleep disturbance. Melatonin is often used for sleep problems in childhood; however, there is no quality evidence supporting its use in Dravet syndrome. We hypothesized that melatonin would increase total sleep and quality of life for patients with Dravet syndrome. Method(s): A double-blind crossover randomized placebo-controlled trial was conducted, comparing 6 mg regular-release melatonin to placebo for patients with Dravet syndrome and sleep disturbance. The primary outcome measure was total sleep measured by actigraphy, with secondary outcomes including wakefulness after sleep onset (WASO), Sleep Disturbance Scale in Children and Quality of Life in Children with Epilepsy 55 questionnaires, caregiver reports of clinical change, seizure diary and serum antiepileptic drug levels. We also compared actigraphy data of patients with Dravet syndrome to an age-matched healthy control group. Result(s): A total of 13 patients completed the study. There was no difference in total sleep or WASO between melatonin and placebo. However, of the 11 patients for whom caregivers reported a clear clinical difference between treatments (blinded), 8 reported improvement on melatonin (P < .05). Interestingly, when compared to patients in the control group, patients with Dravet syndrome had significantly increased total sleep (P = .002). Conclusion(s): Melatonin did not increase total sleep; however, blinded caregiver reports indicate treatment with melatonin provided considerable clinical benefit for some patients with Dravet syndrome and sleep disturbance.Copyright © 2018 American Academy of Sleep Medicine. All right reserved. | en |
dc.language | en | en |
dc.language | English | en |
dc.publisher | American Academy of Sleep Medicine (2510 N. Frontage Road, Darien IL 60561, United States) | en |
dc.relation.ispartof | Journal of Clinical Sleep Medicine | en |
dc.title | Randomized controlled trial of melatonin for sleep disturbance in dravet syndrome: The DREAMS study. | en |
dc.type | Article | en |
dc.type.studyortrial | Randomised controlled trial | - |
dc.identifier.doi | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.5664/jcsm.7376 | en |
dc.publisher.place | United States | en |
dc.identifier.pubmedid | 30353809 [http://www.ncbi.nlm.nih.gov/pubmed/?term=30353809] | en |
dc.identifier.source | 624501037 | en |
dc.identifier.institution | (Myers, Ellis, Grinton, Roten, Lightfoot, Scheffer) Epilepsy Research Centre, Department of Medicine, University of Melbourne, Austin Health, Heidelberg, VIC, Australia (Myers) Departments of Pediatrics and Neurology and Neurosurgery, Faculty of Medicine, McGill University, Montreal, QC, Canada (Davey) Melbourne Children's Sleep Centre, Monash Children's Hospital, Melbourne, VIC, Australia (Ching) Pharmacy Department, Austin Health, Heidelberg, VIC, Australia (Scheffer) Department of Paediatrics, University of Melbourne, Parkville, VIC, Australia (Scheffer) Department of Neurology, Royal Children's Hospital, Parkville, VIC, Australia (Scheffer) Florey Institute of Neuroscience and Mental Health, Heidelberg, VIC, Australia | en |
dc.description.address | K.A. Myers, Montreal Children's Hospital, 1001 Decarie Blvd, Montreal, PQ H4A 3J1, Canada. E-mail: kenneth.myers@mcgill.ca | en |
dc.description.publicationstatus | Embase | en |
dc.rights.statement | Copyright 2018 Elsevier B.V., All rights reserved. | en |
dc.subect.keywords | Actigraphy Dravet syndrome Melatonin Scn1a Sleep | en |
dc.identifier.authoremail | Myers K.A.; kenneth.myers@mcgill.ca | en |
item.cerifentitytype | Publications | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | none | - |
item.openairetype | Article | - |
Appears in Collections: | Articles |
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