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DC Field | Value | Language |
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dc.contributor.author | Low M.S.Y. | en |
dc.contributor.author | Kalff A. | en |
dc.contributor.author | Bergin K. | en |
dc.contributor.author | Coutsouvelis J. | en |
dc.contributor.author | Spencer A. | en |
dc.contributor.author | Yuen H.L.A. | en |
dc.contributor.author | Fedele P. | en |
dc.contributor.author | Walker P. | en |
dc.contributor.author | Grigoriadis G. | en |
dc.date.accessioned | 2021-05-14T12:39:31Z | en |
dc.date.available | 2021-05-14T12:39:31Z | en |
dc.date.copyright | 2018 | en |
dc.date.created | 20190103 | en |
dc.date.issued | 2019-01-03 | en |
dc.identifier.citation | Leukemia and Lymphoma. 59 (12) (pp 2842-2846), 2018. Date of Publication: 02 Dec 2018. | en |
dc.identifier.issn | 1042-8194 | en |
dc.identifier.uri | https://repository.monashhealth.org/monashhealthjspui/handle/1/37228 | en |
dc.description.abstract | There is limited data describing dexamethasone, cyclophosphamide, etoposide, and cisplatin (DCEP) in relapsed refractory multiple myeloma (RRMM). We reviewed 65 patients with RRMM receiving DCEP between 2005 and 2017 in two Melbourne Hospitals. Patients had received a mean of three prior treatment lines (range, 1-11). The mean number of cycles of DCEP was two (range, 1-4). Overall response rate (ORR) was 55% whilst 19% achieved MR and SD. Median overall survival (OS) was 9.6 months. Those bridged to autologous stem cell transplant (ASCT) had significantly improved OS compared to those who were not (median 32.8 vs. 10.7 months, p=.0004). Significant treatment-related mortality (TRM) was observed (9.7%), mostly attributable to grade 3-4 neutropenia and febrile neutropenia. Mandatory use of G-CSF is, therefore, warranted to prevent septic complications. In heavily pretreated RRMM, DCEP is an effective bridge to definitive therapy but in the absence of the latter, its value is questionable.Copyright © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group. | en |
dc.language | en | en |
dc.language | English | en |
dc.publisher | Taylor and Francis Ltd | en |
dc.relation.ispartof | Leukemia and Lymphoma | en |
dc.title | DCEP as a bridge to ongoing therapies for advanced relapsed and/or refractory multiple myeloma. | en |
dc.type | Article | en |
dc.identifier.doi | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1080/10428194.2018.1454595 | en |
dc.publisher.place | United Kingdom | en |
dc.identifier.pubmedid | 29616871 [http://www.ncbi.nlm.nih.gov/pubmed/?term=29616871] | en |
dc.identifier.source | 621563065 | en |
dc.identifier.institution | (Yuen, Kalff, Walker, Bergin, Grigoriadis, Spencer) Department of Clinical Haematology, Alfred Health, Melbourne, Australia (Yuen, Low, Fedele, Grigoriadis) Monash Haematology, Monash Health, Melbourne, Australia (Low, Grigoriadis) Hudson Institute of Medical Research and Southern Clinical School, Monash University, Clayton, Australia (Fedele) Walter and Eliza Hall Institute of Medical Research, University of Melbourne, Melbourne, Australia (Coutsouvelis) Centre for Medicine Use and Safety, Monash University, Clayton, Australia (Coutsouvelis) Pharmacy Department, Alfred Health, Melbourne, Australia (Spencer) Australian Centre for Blood Diseases, Monash University, Melbourne, Australia | en |
dc.description.address | G. Grigoriadis, Monash Medical Centre, 246 Clayton Rd, Clayton, VIC 3168, Australia. E-mail: george.grigoriadis@monash.edu | en |
dc.description.publicationstatus | Embase | en |
dc.rights.statement | Copyright 2019 Elsevier B.V., All rights reserved. | en |
dc.subect.keywords | chemotherapeutic approaches DCEP multiple myeloma Relapsed/refractory salvage chemotherapy | en |
dc.identifier.authoremail | Grigoriadis G.; george.grigoriadis@monash.edu Spencer A.; andrew.spencer@monash.edu | en |
item.cerifentitytype | Publications | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | none | - |
item.openairetype | Article | - |
crisitem.author.dept | Haematology | - |
crisitem.author.dept | University of Melbourne | - |
crisitem.author.dept | Haematology | - |
crisitem.author.dept | Haematology | - |
Appears in Collections: | Articles |
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