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Please use this identifier to cite or link to this item: https://repository.monashhealth.org/monashhealthjspui/handle/1/37548
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dc.contributor.authorHickie I.en
dc.contributor.authorSaunders C.en
dc.contributor.authorHunt C.en
dc.contributor.authorScott C.en
dc.contributor.authorAmor D.en
dc.contributor.authorMarsh D.en
dc.contributor.authorEdkins E.en
dc.contributor.authorSalisbury E.en
dc.contributor.authorHaan E.en
dc.contributor.authorNeidermayr E.en
dc.contributor.authorMacrae F.en
dc.contributor.authorFarshid G.en
dc.contributor.authorLindeman G.en
dc.contributor.authorChenevix-Trench G.en
dc.contributor.authorMann G.en
dc.contributor.authorGill G.en
dc.contributor.authorThorne H.en
dc.contributor.authorCampbell I.en
dc.contributor.authorWinship I.en
dc.contributor.authorGoldblatt J.en
dc.contributor.authorFlanagan J.en
dc.contributor.authorKollias J.en
dc.contributor.authorVisvader J.en
dc.contributor.authorStone J.en
dc.contributor.authorTaylor J.en
dc.contributor.authorBurke J.en
dc.contributor.authorSaunus J.en
dc.contributor.authorForbes J.en
dc.contributor.authorBeesley J.en
dc.contributor.authorKirk J.en
dc.contributor.authorFrench J.en
dc.contributor.authorTucker K.en
dc.contributor.authorWu K.en
dc.contributor.authorPhillips K.en
dc.contributor.authorLipton L.en
dc.contributor.authorAndrews L.en
dc.contributor.authorLobb E.en
dc.contributor.authorWalker L.en
dc.contributor.authorKentwell M.en
dc.contributor.authorSpurdle A.en
dc.contributor.authorCummings M.en
dc.contributor.authorGleeson M.en
dc.contributor.authorHarris M.en
dc.contributor.authorJenkins M.en
dc.contributor.authorYoung M.A.en
dc.contributor.authorDelatycki M.en
dc.contributor.authorWallis M.en
dc.contributor.authorBurgess M.en
dc.contributor.authorPrice M.en
dc.contributor.authorBrown M.en
dc.contributor.authorBogwitz M.en
dc.contributor.authorField M.en
dc.contributor.authorFriedlander M.en
dc.contributor.authorGattas M.en
dc.contributor.authorSaleh M.en
dc.contributor.authorHayward N.en
dc.contributor.authorPachter N.en
dc.contributor.authorCohen P.en
dc.contributor.authorDuijf P.en
dc.contributor.authorJames P.en
dc.contributor.authorSimpson P.en
dc.contributor.authorFong P.en
dc.contributor.authorButow P.en
dc.contributor.authorWilliams R.en
dc.contributor.authorKefford R.en
dc.contributor.authorScott R.en
dc.contributor.authorBalleine R.en
dc.contributor.authorDawson S.-J.en
dc.contributor.authorLok S.en
dc.contributor.authorO'Connell S.en
dc.contributor.authorGreening S.en
dc.contributor.authorNightingale S.en
dc.contributor.authorEdwards S.en
dc.contributor.authorFox S.en
dc.contributor.authorMcLachlan S.-A.en
dc.contributor.authorLakhani S.en
dc.contributor.authorThomas S.en
dc.contributor.authorAntill Y.en
dc.contributor.authorJoo J.E.en
dc.contributor.authorDowty J.G.en
dc.contributor.authorMilne R.L.en
dc.contributor.authorWong E.M.en
dc.contributor.authorDugue P.-A.en
dc.contributor.authorEnglish D.en
dc.contributor.authorHopper J.L.en
dc.contributor.authorGoldgar D.E.en
dc.contributor.authorGiles G.G.en
dc.contributor.authorSouthey M.C.en
dc.contributor.authorSexton A.en
dc.contributor.authorChristian A.en
dc.contributor.authorTrainer A.en
dc.contributor.authorSpigelman A.en
dc.contributor.authorFellows A.en
dc.contributor.authorShelling A.en
dc.contributor.authorDe Fazio A.en
dc.contributor.authorBlackburn A.en
dc.contributor.authorCrook A.en
dc.contributor.authorMeiser B.en
dc.contributor.authorPatterson B.en
dc.contributor.authorClarke C.en
dc.date.accessioned2021-05-14T12:46:48Zen
dc.date.available2021-05-14T12:46:48Zen
dc.date.copyright2018en
dc.date.created20180406en
dc.date.issued2018-04-06en
dc.identifier.citationNature Communications. 9 (1) (no pagination), 2018. Article Number: 867. Date of Publication: 01 Dec 2018.en
dc.identifier.issn2041-1723 (electronic)en
dc.identifier.urihttps://repository.monashhealth.org/monashhealthjspui/handle/1/37548en
dc.description.abstractMendelian-like inheritance of germline DNA methylation in cancer susceptibility genes has been previously reported. We aimed to scan the genome for heritable methylation marks associated with breast cancer susceptibility by studying 25 Australian multiple-case breast cancer families. Here we report genome-wide DNA methylation measured in 210 peripheral blood DNA samples provided by family members using the Infinium HumanMethylation450. We develop and apply a new statistical method to identify heritable methylation marks based on complex segregation analysis. We estimate carrier probabilities for the 1000 most heritable methylation marks based on family structure, and we use Cox proportional hazards survival analysis to identify 24 methylation marks with corresponding carrier probabilities significantly associated with breast cancer. We replicate an association with breast cancer risk for four of the 24 marks using an independent nested case-control study. Here, we report a novel approach for identifying heritable DNA methylation marks associated with breast cancer risk.Copyright © 2018 The Author(s).en
dc.languageenen
dc.languageEnglishen
dc.publisherNature Publishing Group (Houndmills, Basingstoke, Hampshire RG21 6XS, United Kingdom)en
dc.relation.ispartofNature Communicationsen
dc.titleHeritable DNA methylation marks associated with susceptibility to breast cancer /631/67/69 /631/337/176/1988 /692/699/67/1347 /692/308/2056 /45 /45/61 article.en
dc.typeArticleen
dc.type.studyortrialObservational study (cohort, case-control, cross sectional or survey)-
dc.identifier.doihttp://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1038/s41467-018-03058-6en
dc.publisher.placeUnited Kingdomen
dc.identifier.orcidMilne, Roger L.; ORCID: http://orcid.org/0000-0001-5764-7268en
dc.identifier.pubmedid29491469 [http://www.ncbi.nlm.nih.gov/pubmed/?term=29491469]en
dc.identifier.source620918490en
dc.identifier.institution(Joo, Wong, Goldgar, Southey) Department of Pathology, University of Melbourne, Melbourne, VIC 3010, Australia (Joo, Wong, Southey) Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC 3168, Australia (Dowty, Milne, Dugue, English, Hopper, Giles) Centre for Epidemiology and Biostatistics, University of Melbourne, Melbourne, VIC 3010, Australia (Milne, Dugue, English, Giles) Cancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, VIC 3004, Australia (Goldgar) Huntsman Cancer Institute, Salt Lake, UT 84112, United States (Sexton, Macrae, Taylor, Kentwell, Bogwitz, James) Familial Cancer Centre, Royal Melbourne Hospital Australia, Grattan Street, Parkville, VIC 3050, Australia (Christian) Genetics Department, Central Region Genetics Service, Wellington Hospital New Zealand, Wellington 6021, New Zealand (Trainer, Fellows, Neidermayr, Thorne, Campbell, Dawson, Nightingale) Peter MacCallum Cancer Centre, Victorian Comprehensive Cancer Centre Australia, Grattan Street, Melbourne 3000, Australia (Spigelman) Family Cancer Clinic, St Vincents Hospital Australia, Darlinghurst, NSW 2010, Australia (Shelling) Obstetrics and Gynaecology, University of Auckland New Zealand, Auckland 1010, New Zealand (De Fazio) Dept. Gynaecological Oncology, Westmead Institute for Cancer Research, Westmead Hospital Australia, Westmead, NSW 2145, Australia (Blackburn) Australian National University Australia, P.O. Box 334, Canberra, ACT 2601, Australia (Crook) Department of Clinical Genetics, Level 3E, Royal North Shore Hospital Australia, St Leonards, NSW 2065, Australia (Meiser) Prince of Wales Hospital, University of New South Wales, UNSW Australia, Sydney, NSW 2052, Australia (Patterson) Clinical Genetics Service, Royal Hobart Hospital Australia, GPO Box 1061, Hobart, TAS 7001, Australia (Clarke) Westmead Institute for Cancer Research, University of Sydney, Westmead Hospital Australia, Sydney, NSW 2145, Australia (Saunders) School of Surgery and Pathology, QE11 Medical Centre Australia, M block 2nd Floor, Nedlands, WA 6907, Australia (Hunt) Southern Health Familial Cancer Centre, Monash Medical Centre, Special Medicine Building Australia, 246 Clayton Rd, Clayton, VIC 3168, Australia (Scott, Visvader) Walter and Eliza Hall Institute, C/o Royal Melbourne Hospital Australia, Grattan Street, Parkville 3050, Australia (Amor, Delatycki, Burgess) Genetic Health Services Victoria, Royal Children's Hospital Australia, Melbourne, VIC 3050, Australia (Marsh) Kolling Institute of Medical Research, Royal North Shore Hospital Australia, St Leonards, NSW 2065, Australia (Edkins) Clinical Chemistry, Princess Margret Hospital for Children Australia, Box D184, Perth, WA 6001, Australia (Salisbury) Anatomical Pathology, Prince of Wales Hospital Australia, Randwick, NSW 2031, Australia (Haan) Department of Medical Genetics, Women's and Children's Hospital Australia, North Adelaide, SA 5006, Australia (Farshid) Tissue Pathology, IMVS Australia, Adelaide, SA 5000, Australia (Lindeman) Breast Cancer Laboratory, Walter and Eliza Hall Institute, PO Royal Melbourne, Hospital Australia, Parkville, VIC 3050, Australia (Chenevix-Trench, Spurdle, Hayward, Edwards) Queensland Institute of Medical Research, Royal Brisbane Hospital Australia, Herston, QLD 4029, Australia (Mann, Beesley, French) Westmead Institute for Cancer Research, Westmead Millennium Institute Australia, Westmead, NSW 2145, Australia (Gill) Department of Surgery, Royal Adelaide Hospital Australia, Adelaide, SA 5000, Australia (Hickie) Brain and Mind Centre Australia, Camperdown, NSW 2050, Australia (Winship, Pachter) Department of Medicine, Royal Melbourne Hospital Australia, Parkville 3050, Australia (Goldblatt) Genetic Services of WA, King Edward Memorial Hospital Australia, 374 Bagot Road, Subiaco, WA 6008, Australia (Flanagan) Epigenetics Unit, Department of Surgery and Oncology, Imperial College London England, London W12 0NN, United Kingdom (Kollias) Breast Endocrine and Surgical Unit, Royal Adelaide Hospital Australia, North Terrace, SA 5000, Australia (Kollias) Centre for Genetic Origins of Health and Disease, University of Western Australia Australia, 35 Stirling Highway, Crawley, WA 6009, Australia (Burke) Royal Hobart Hospital Australia, GPO Box 1061 L, Hobart, TAS 7001, Australia (Stone, Saunus) Breast Pathology, University of Queensland Centre for Clinical Research, Royal Brisbane and Women's Hospital Australia, Herston, Qld 4029, Australia (Forbes) Dire. Surgical Oncology, University of Newcastle, Newcastle Mater Hospital Australia, Waratah, NSW 2298, Australia (Kirk, Andrews) Familial Cancer Service, Department of Medicine, Westmead Hospital Australia, Westmead, NSW 2145, Australia (Tucker, Williams) Grid.415193.b Hereditary Cancer Clinic, Prince of Wales Hospital Australia, Randwick, NSW 2031, Australia (Wu) Family Cancer Clinic, St Vincent's Hospital Sydney Australia, Darlinghurst 2010, Australia (Phillips) Grid.431578.c Department of Medical Oncology, Peter MacCallum Cancer Centre, Victorian Comprehensive Cancer Centre Australia, Grattan Street, Melbourne, VIC 3000, Australia (Lipton) Medical Oncology and Clinical Haematology Unit, Western Hospital Australia, Footscray, VIC, Australia (Lobb) School of Medicine, University of Notre Dame Australia, Kogarah, NSW 2217, Australia (Walker) Department of Pathology, University of Otago New Zealand, Christchurch, New Zealand (Cummings) Department of Pathology, University of Queensland Medical School Australia, Herston, QLD 4006, Australia (Gleeson, O'Connell) Hunter Family Cancer Service Australia, PO Box 84, Waratah, NSW 2298, Australia (Harris) Family Cancer Clinic, Monash Medical Centre Australia, Clayton 3168, Australia (Jenkins) Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne Australia, Carlton, VIC 3053, Australia (Young) Garvan Institute of Medical Research, Kinghorn Cancer Centre Australia, Darlinghurst, NSW 2010, Australia (Wallis) Family Cancer Clinic, Austin Health Australia, Heidelberg, VIC 3084, Australia (Price) Medical Psychology, University of Sydney Australia, Sydney 2006, Australia (Brown) University of Queensland Australia, St. Lucia, QLD 4072, Australia (Field) Clinical Geneticist, Royal North Shore Hospital Australia, St Leonards, NSW 2065, Australia (Friedlander) Department of Medical Oncology, Prince of Wales Hospital Australia, Randwick, NSW 2031, Australia (Gattas) Queensland Clinical Genetic Service, Royal Children's Hospital, Bramston Terrace Herston Australia, Herston, QLD 4020, Australia (Saleh) Centre for Genetic Education, Prince of Wales Hospital Australia, Randwick, NSW 2031, Australia (Cohen) Gynaecological Cancer Research, St John of God Subiaco Hospital Australia, 12 Salvado Road, Subiaco, WA 6008, Australia (Duijf) University of Queensland Diamantina Institute Australia, Brisbane, QLD 4102, Australia (Simpson) University of Queensland, RBWH Campus Australia, Herston, QLD 4029, Australia (Fong) Regional Cancer and Blood Services, Auckland City Hospital New Zealand, Level 1 Building 7, Grafton, Auckland 1023, New Zealand (Butow, Balleine) Medical Psychology Unit, Royal Prince Alfred Hospital Australia, Camperdown, NSW 2204, Australia (Kefford) Department of Medical Oncology, Westmead Hospital Australia, Westmead, NSW 2145, Australia (Scott) Hunter Area Pathology Service, John Hunter Hospital Australia, New Lambton Heights, NSW 2310, Australia (Lok) Department of Medical Oncology, Royal Melbourne Hospital Australia, Parkville, VIC 3050, Australia (Greening) Illawarra Cancer Centre, Wollongong Hospital, South Coast Mail Centre Australia, Private Mail Bag 8808, Wollongong, NSW 2521, Australia (Fox) Pathology Department, Peter MacCallum Cancer Centre, Victorian Comprehensive Cancer Centre Australia, Grattan Street, Melbourne 3000, Australia (McLachlan) Department of Oncology, St Vincent's Hospital Australia, 41 Victoria Parade, Fitzroy, VIC 3065, Australia (Lakhani) UQ Centre for Clinical Research, University of Queensland, Royal Brisbane and Women's Hospital Herston Australia, Level 6 Building 71/918, St, Herston 4029, Australia (Thomas) Breast/Ovarian Cancer Risk Management Clinic, Royal Melbourne Hospital Australia, Parkville, VIC 3050, Australia (Antill) Family Cancer Clinic, Cabrini Hospital Australia, Malvern, VIC 3144, Australiaen
dc.description.addressM.C. Southey, Department of Pathology, University of Melbourne, Melbourne, VIC 3010, Australia. E-mail: msouthey@unimelb.edu.auen
dc.description.publicationstatusEmbaseen
dc.rights.statementCopyright 2018 Elsevier B.V., All rights reserved.en
dc.identifier.authoremailSouthey M.C.; msouthey@unimelb.edu.auen
dc.description.grantOrganization: (NBCF) *National Breast Cancer Foundation* Organization No: 501100001026 Country: Australia Organization: *National Breast Cancer Foundation* Organization No: 501100001026 Country: Australia Organization: (NCI) *National Cancer Institute* Organization No: 100000054 Country: United States Organization: *National Health and Medical Research Council* Organization No: 501100000925 Country: Australia No: 1011618 Organization: (NHMRC) *National Health and Medical Research Council* Organization No: 501100000925 Country: Australiaen
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.openairetypeArticle-
crisitem.author.deptOncology-
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