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DC Field | Value | Language |
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dc.contributor.author | Low M.S.Y. | en |
dc.contributor.author | Brodie E.J. | en |
dc.contributor.author | Tarlinton D.M. | en |
dc.contributor.author | Infantino S. | en |
dc.date.accessioned | 2021-05-14T12:48:35Z | en |
dc.date.available | 2021-05-14T12:48:35Z | en |
dc.date.copyright | 2018 | en |
dc.date.created | 20180313 | en |
dc.date.issued | 2018-03-13 | en |
dc.identifier.citation | Frontiers in Immunology. 9 (MAR) (no pagination), 2018. Article Number: 401. Date of Publication: 01 Mar 2018. | en |
dc.identifier.issn | 1664-3224 (electronic) | en |
dc.identifier.uri | https://repository.monashhealth.org/monashhealthjspui/handle/1/37633 | en |
dc.description.abstract | Systemic lupus erythematosus (SLE) is a progressive autoimmune disease characterized by increased sensitivity to self-antigens, auto-antibody production, and systemic inflammation. B cells have been implicated in disease progression and as such represent an attractive therapeutic target. Lyn is a Src family tyrosine kinase that plays a major role in regulating signaling pathways within B cells as well as other hematopoietic cells. Its role in initiating negative signaling cascades is especially critical as exemplified by Lyn-/- mice developing an SLE-like disease with plasma cell hyperplasia, underscoring the importance of tightly regulating signaling within B cells. This review highlights recent advances in our understanding of the function of the Src family tyrosine kinase Lyn in B lymphocytes and its contribution to positive and negative signaling pathways that are dysregulated in autoimmunity.Copyright © 2018 Brodie, Infantino, Low and Tarlinton. | en |
dc.language | English | en |
dc.language | en | en |
dc.publisher | Frontiers Media S.A. (E-mail: info@frontiersin.org) | en |
dc.relation.ispartof | Frontiers in Immunology | en |
dc.title | Lyn, lupus, and (B) lymphocytes, a lesson on the critical balance of kinase signaling in immunity. | en |
dc.type | Review | en |
dc.type.studyortrial | Review article (e.g. literature review, narrative review) | - |
dc.identifier.doi | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.3389/fimmu.2018.00401 | en |
dc.publisher.place | Switzerland | en |
dc.identifier.source | 620914679 | en |
dc.identifier.institution | (Brodie, Infantino, Low, Tarlinton) Department of Immunology and Pathology, Monash University, Melbourne, VIC, Australia (Low) Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia (Low) Immunology Division, Walter and Eliza Hall Institute of Medical Research, University of Melbourne, Parkville, VIC, Australia (Low) Department of Haematology, Monash Health, Monash Hospital, Clayton, VIC, Australia | en |
dc.description.address | D.M. Tarlinton, Department of Immunology and Pathology, Monash University, Melbourne, VIC, Australia. E-mail: david.tarlinton@monash.edu | en |
dc.description.publicationstatus | Embase | en |
dc.rights.statement | Copyright 2018 Elsevier B.V., All rights reserved. | en |
dc.subect.keywords | Autoimmunity B cell B-cell receptor Cell signaling Lupus Lyn SFK Systemic lupus erythematosus | en |
dc.identifier.authoremail | Tarlinton D.M.; david.tarlinton@monash.edu | en |
dc.description.grant | Organization: (NHMRC) *National Health and Medical Research Council* Organization No: 501100000925 Country: Australia | en |
item.cerifentitytype | Publications | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | none | - |
item.openairetype | Review | - |
Appears in Collections: | Articles |
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