Please use this identifier to cite or link to this item:
https://repository.monashhealth.org/monashhealthjspui/handle/1/37893
Conference/Presentation Title: | Associations of SLE-QoL, SF-36 and patient's global rating change (GRC) with lupus low disease activity state (LLDAS): A longitudinal study. | Authors: | Kasitanon N.;Kandane-Rathnayake R.;Morand E. ;Louthrenoo W. | Monash Health Department(s): | Rheumatology | Institution: | (Louthrenoo, Kasitanon) Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai, Thailand (Morand, Kandane-Rathnayake) School of Clinical Sciences at Monash Health, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, VIC, Australia | Presentation/Conference Date: | 16-Oct-2018 | Copyright year: | 2018 | Publisher: | Blackwell Publishing | Publication information: | International Journal of Rheumatic Diseases. Conference: 20th Asia Pacific League of Associations for Rheumatology Congress, APLAR 2018. Kaohsiung Taiwan (Republic of China). 21 (Supplement 1) (pp 139), 2018. Date of Publication: September 2018. | Abstract: | Objective: To examine the associations of patient reported out-comes (PROs) with LLDAS. Method(s): SLE patients attending a rheumatology clinic in Thailand between 2013 and 2017 completed specific (SLE-QoL) and generic (SF36) health-related quality of life (HR-QoL) surveys, and rated their global change (GRC) in QoL compared to their previous visit using a 7-point Likert scale. Patients' changes in QoL were categorised as 'no change' (-1 to +1), 'deterioration' (-2 to-7) or 'improvement' (+2, to +7). LLDAS was defined as described (Franklyn K, et al. Ann Rheum Dis 16; 75: 1615). Associations of PROs (SLE-QoL, SF36 and GRC) with LLDAS were examined using generalised estimating equations. Result(s): 337 patients (2062 visits) were included in the study. Patients' median age [inter-quartile range (IQR)] and study duration were 37 [28, 48] years and 1162 [567, 1246] days, respectively. 81% of patients achieved LLDAS at least once during the study period. SLE-QoL and SF36 survey components were significantly correlated (P < 0.01). Patients who were in LLDAS had statistically significantly higher scores in both SLE-QoL and SF36 surveys when compared to patients who were not. Patients reported improvement in 58%, deterioration in 15% and no change in QoL in 27% of all visits. Compared to the no change group, QoL deterioration was significantly associated with reduced odds of subsequently achieving LLDAS (OR 0.53, 95%CI: 0.39-0.72, P < 0.001), but QoL improvement was not associated with increased odds of achieving LLDAS. Conclusion(s): LLDAS is associated with improved HR-QoL, and improving QoL predicts LLDAS attainment. | Conference Start Date: | 2018-09-06 | Conference End Date: | 2018-09-09 | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1111/1756-185X.13361 | ISSN: | 1756-185X | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/37893 | Type: | Conference Abstract |
Appears in Collections: | Conferences |
Show full item record
Items in Monash Health Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.