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DC Field | Value | Language |
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dc.contributor.author | Dusting G.J. | en |
dc.contributor.author | Cao A.H. | en |
dc.contributor.author | Hood S.G. | en |
dc.contributor.author | Huynh K. | en |
dc.contributor.author | Kiriazis H. | en |
dc.contributor.author | Du X.-J. | en |
dc.contributor.author | Julius T.L. | en |
dc.contributor.author | Figtree G.A. | en |
dc.contributor.author | Kaye D.M. | en |
dc.contributor.author | Ritchie R.H. | en |
dc.contributor.author | Tate M. | en |
dc.contributor.author | Deo M. | en |
dc.date.accessioned | 2021-05-14T13:13:29Z | en |
dc.date.available | 2021-05-14T13:13:29Z | en |
dc.date.copyright | 2017 | en |
dc.date.created | 20170929 | en |
dc.date.issued | 2017-09-29 | en |
dc.identifier.citation | Diabetes and Vascular Disease Research. 14 (5) (pp 423-433), 2017. Date of Publication: 01 Sep 2017. | en |
dc.identifier.issn | 1479-1641 | en |
dc.identifier.uri | https://repository.monashhealth.org/monashhealthjspui/handle/1/38736 | en |
dc.description.abstract | Diabetic cardiomyopathy is a major contributor to the increasing burden of heart failure globally. Effective therapies remain elusive, in part due to the incomplete understanding of the mechanisms underlying diabetes-induced myocardial injury. The objective of this study was to assess the direct impact of insulin replacement on left ventricle structure and function in a rat model of diabetes. Male Sprague-Dawley rats were administered streptozotocin (55 mg/kg i.v.) or citrate vehicle and were followed for 8 weeks. A subset of diabetic rats were allocated to insulin replacement (6 IU/day insulin s.c.) for the final 4 weeks of the 8-week time period. Diabetes induced the characteristic systemic complications of diabetes (hyperglycaemia, polyuria, kidney hypertrophy) and was accompanied by marked left ventricle remodelling (cardiomyocyte hypertrophy, left ventricle collagen content) and diastolic dysfunction (transmitral E/A, left ventricle-dP/dt). Importantly, these systemic and cardiac impairments were ameliorated markedly following insulin replacement, and moreover, markers of the diabetic cardiomyopathy phenotype were significantly correlated with the extent of hyperglycaemia. In summary, these data suggest that poor glucose control directly contributes towards the underlying features of experimental diabetic cardiomyopathy, at least in the early stages, and that adequate replacement ameliorates this.Copyright © The Author(s) 2017. | en |
dc.language | en | en |
dc.language | English | en |
dc.publisher | SAGE Publications Ltd (E-mail: info@sagepub.co.uk) | en |
dc.relation.ispartof | Diabetes and Vascular Disease Research | en |
dc.title | Insulin replacement limits progression of diabetic cardiomyopathy in the low-dose streptozotocin-induced diabetic rat. | en |
dc.type | Article | en |
dc.identifier.doi | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1177/1479164117710390 | en |
dc.publisher.place | United Kingdom | en |
dc.identifier.pubmedid | 28565941 [http://www.ncbi.nlm.nih.gov/pubmed/?term=28565941] | en |
dc.identifier.source | 618419503 | en |
dc.identifier.institution | (Tate, Deo, Cao, Huynh, Julius, Ritchie) Heart Failure Pharmacology Laboratory, Baker IDI Heart, Diabetes Institute, PO Box 6492, Melbourne, VIC 3004, Australia (Cao) Centre for Inflammatory Diseases, Monash University, Monash Medical Centre, Clayton, VIC, Australia (Hood) Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, Australia (Kiriazis, Du) Experimental Cardiology Laboratory, Baker IDI Heart, Diabetes Institute, Melbourne, VIC, Australia (Figtree) North Shore Heart Research Group, Kolling Institute, University of Sydney, Sydney, NSW, Australia (Dusting) Centre for Eye Research Australia, University of Melbourne, East Melbourne, VIC, Australia (Kaye) Heart Failure Research Group, Baker IDI Heart, Diabetes Institute, Melbourne, VIC, Australia (Kaye, Ritchie) Department of Medicine, Monash University, Clayton, VIC, Australia | en |
dc.description.address | R.H. Ritchie, Heart Failure Pharmacology Laboratory, Baker IDI Heart, Diabetes Institute, PO Box 6492, Melbourne, VIC 3004, Australia. E-mail: rebecca.ritchie@bakeridi.edu.au | en |
dc.description.publicationstatus | Embase | en |
dc.rights.statement | Copyright 2017 Elsevier B.V., All rights reserved. | en |
dc.subect.keywords | cardiac remodelling Diabetes diabetic cardiomyopathy diastolic dysfunction insulin myocardial inflammation | en |
dc.identifier.authoremail | Ritchie R.H.; rebecca.ritchie@bakeridi.edu.au | en |
dc.description.grant | No: ID1059660 Organization: (NHMRC) *National Health and Medical Research Council* Organization No: 501100000925 Country: Australia Organization: (NHMRC) *National Health and Medical Research Council* Organization No: 501100000925 Country: Australia Organization: (THF) *Heart Foundation* Organization No: 100002129 Country: United States | en |
item.fulltext | No Fulltext | - |
item.cerifentitytype | Publications | - |
item.openairetype | Article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | none | - |
Appears in Collections: | Articles |
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