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DC Field | Value | Language |
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dc.contributor.author | Indumathy S. | en |
dc.contributor.author | Pueschl D. | en |
dc.contributor.author | Bergmann M. | en |
dc.contributor.author | Schuppe H.-C. | en |
dc.contributor.author | Hedger M.P. | en |
dc.contributor.author | Loveland B.E. | en |
dc.contributor.author | Loveland K.L. | en |
dc.contributor.author | Klein B. | en |
dc.date.accessioned | 2021-05-14T13:14:01Z | en |
dc.date.available | 2021-05-14T13:14:01Z | en |
dc.date.copyright | 2017 | en |
dc.date.created | 20171216 | en |
dc.date.issued | 2017-12-16 | en |
dc.identifier.citation | Frontiers in Endocrinology. 8 (NOV) (no pagination), 2017. Article Number: 307. Date of Publication: 20 Nov 2017. | en |
dc.identifier.issn | 1664-2392 (electronic) | en |
dc.identifier.uri | https://repository.monashhealth.org/monashhealthjspui/handle/1/38758 | en |
dc.description.abstract | Germline development in vivo is dependent on the environment formed by somatic cells and the differentiation cues they provide; hence, the impact of local factors is highly relevant to the production of sperm. Knowledge of how somatic and germline cells interact is central to achieving biomedical goals relating to restoring, preserving or restricting fertility in humans. This review discusses the growing understanding of how cytokines contribute to testicular function and maintenance of male reproductive health, and to the pathologies associated with their abnormal activity in this organ. Here we consider both cytokines that signal through JAKs and are regulated by SOCS, and those utilizing other pathways, such as the MAP kinases and SMADs. The importance of cytokines in the establishment and maintenance of the testis as an immune-privilege site are described. Current research relating to the involvement of immune cells in testis development and disease is highlighted. This includes new data relating to testicular cancer which reinforce the understanding that tumorigenic cells shape their microenvironment through cytokine actions. Clinical implications in pathologies relating to local inflammation and to immunotherapies are discussed.Copyright © 2017 Loveland, Klein, Pueschl, Indumathy, Bergmann, Loveland, Hedger and Schuppe. | en |
dc.language | English | en |
dc.language | en | en |
dc.publisher | Frontiers Media S.A. (E-mail: info@frontiersin.org) | en |
dc.relation.ispartof | Frontiers in Endocrinology | en |
dc.title | Cytokines in male fertility and reproductive pathologies: Immunoregulation and beyond. | en |
dc.type | Review | en |
dc.type.studyortrial | Review article (e.g. literature review, narrative review) | - |
dc.identifier.doi | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.3389/fendo.2017.00307 | en |
dc.publisher.place | Switzerland | en |
dc.identifier.source | 619330967 | en |
dc.identifier.institution | (Loveland, Pueschl, Indumathy, Hedger) Centre for Reproductive Health, Hudson Institute of Medical Research, Clayton, VIC, Australia (Loveland, Pueschl, Indumathy, Hedger) Department of Molecular and Translational Sciences, School of Clinical Sciences, Monash Medical Centre, Monash University, Clayton, VIC, Australia (Loveland) Department of Anatomy and Developmental Biology, Monash University, Clayton, VIC, Australia (Klein, Pueschl, Indumathy, Bergmann) Institute of Veterinary Anatomy, Histology and Embryology, Justus Liebig University Giessen, Giessen, Germany (Klein) Institute of Anatomy and Cell Biology, Justus Liebig University Giessen, Giessen, Germany (Loveland) Burnet Institute, Melbourne, VIC, Australia (Schuppe) Department of Urology, Pediatric Urology and Andrology, Justus Liebig University Giessen, Giessen, Germany | en |
dc.description.address | K.L. Loveland, Centre for Reproductive Health, Hudson Institute of Medical Research, Clayton, VIC, Australia. E-mail: kate.loveland@monash.edu | en |
dc.description.publicationstatus | Embase | en |
dc.rights.statement | Copyright 2017 Elsevier B.V., All rights reserved. | en |
dc.subect.keywords | Cytokines Immune cells Infertility Macrophages Male reproductive health Spermatogenesis Spermatogonial stem cells Testis cancer | en |
dc.identifier.authoremail | Loveland K.L.; kate.loveland@monash.edu | en |
dc.description.grant | No: 1871/1 Organization: *Monash University* Organization No: 501100001779 Country: Australia No: ID1020269 Organization: (NHMRC) *National Health and Medical Research Council* Organization No: 501100000925 Country: Australia No: ID1063843 Organization: (NHMRC) *National Health and Medical Research Council* Organization No: 501100000925 Country: Australia No: ID1079646 Organization: (NHMRC) *National Health and Medical Research Council* Organization No: 501100000925 Country: Australia No: ID1081987 Organization: (NHMRC) *National Health and Medical Research Council* Organization No: 501100000925 Country: Australia | en |
item.fulltext | No Fulltext | - |
item.cerifentitytype | Publications | - |
item.openairetype | Review | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | none | - |
Appears in Collections: | Articles |
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