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DC Field | Value | Language |
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dc.contributor.author | Choo S.Z. | en |
dc.contributor.author | Polkinghorne K.R. | en |
dc.contributor.author | Kerr P.G. | en |
dc.date.accessioned | 2021-05-14T13:21:22Z | en |
dc.date.available | 2021-05-14T13:21:22Z | en |
dc.date.copyright | 2017 | en |
dc.date.created | 20170913 | en |
dc.date.issued | 2017-09-13 | en |
dc.identifier.citation | Nephrology. Conference: 53rd Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology, ANZSN 2017. Darwin, NT Australia. 22 (Supplement 3) (pp 13), 2017. Date of Publication: September 2017. | en |
dc.identifier.issn | 1440-1797 | en |
dc.identifier.uri | https://repository.monashhealth.org/monashhealthjspui/handle/1/39102 | en |
dc.description.abstract | Aim: To compare biochemical clearances with extended-hours haemodialysis (HD) and haemodiafiltration (HDF) and Fresenius FX80 (FX) and Nipro Elisio (NE) dialysers. Background(s): Extended-hours HD has long been regarded as the optimal form of dialysis for solute clearance. With emerging benefits of HDF, it would be prudent to compare these two head-to-head. Method(s): This is a randomized cross-over trial comparing 8-hours HD to 4-hours HDF. 12 NHD patients underwent a baseline 8-hour HD session, and then randomized to either 2 weeks of 8-hour HD or 4-hour HDF with crossover to the alternative treatment after a 2-week washout period. Subjects were additionally randomized to the NE or FX dialyser in a parallel design. Blood and dialysate samples were collected at baseline and at the end of both study periods. Result(s): Mean (SD) age and BMI were 55.1 +/-11.5 years and 36.4 +/-10.8 respectively. Blood flow (Qb) for HD was 250ml/min and dialysate flow (Qd) 300ml/min. For HDF, Qb was 300ml/min and Qd 500ml/min with mean convection rate 86.1ml/min (20.7 L/session). Urea and creatinine reduction ratios were higher with HD compared to HDF (difference 14.0%, 95% CI 10.6,17.3, p<0.001 & 9.1% 95% CI 11.0,7.2, p<0.001). Fibroblast growth factor 23 (FGF23) clearance was superior with HDF (difference 20.1%, 95% CI 8.7,31.6, p=0.001). No difference was seen in reduction ratios for phosphate, retinol binding protein, alpha-1-microglobulin, beta-2-microglobulin (B2M) and fetuin with both modalities. Compared to NE, FX dialyser achieved higher beta-2-microglobulin clearance (Period 1: difference 7.8%, 95% CI 1.3, 14.4, P=0.02, Period 2: 7.5%, 95%CI 1.0, 14.1, p=0.02). Conclusion(s): Small solute clearance was superior with extended-hours HD while HDF enhanced FGF23 clearance. B2M clearance was improved with Fresenius FX80 dialyser. | en |
dc.language | English | en |
dc.language | en | en |
dc.publisher | Blackwell Publishing | en |
dc.title | Biochemical comparison of 8-hour haemodialysis and 4-hour haemodiafiltration, and two dialysis membranes. | en |
dc.type | Conference Abstract | en |
dc.identifier.affiliation | Nephrology | en |
dc.type.studyortrial | Randomised controlled trial | - |
dc.identifier.doi | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1111/nep.13103 | en |
local.date.conferencestart | 2017-09-04 | en |
dc.identifier.source | 618236224 | en |
dc.identifier.institution | (Choo, Polkinghorne, Kerr) Department of Nephrology, Monash Health, Clayton, VIC, Australia (Polkinghorne, Kerr) Monash University, Clayton, VIC, Australia | en |
dc.description.address | S.Z. Choo, Department of Nephrology, Monash Health, Clayton, VIC, Australia | en |
dc.description.publicationstatus | CONFERENCE ABSTRACT | en |
local.date.conferenceend | 2017-09-06 | en |
dc.rights.statement | Copyright 2017 Elsevier B.V., All rights reserved. | en |
dc.identifier.affiliationext | (Polkinghorne, Kerr) Monash University, Clayton, VIC, Australia | - |
dc.identifier.affiliationmh | (Choo, Polkinghorne, Kerr) Department of Nephrology, Monash Health, Clayton, VIC, Australia | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
item.openairetype | Conference Abstract | - |
crisitem.author.dept | Nephrology | - |
crisitem.author.dept | Nephrology | - |
Appears in Collections: | Conferences |
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