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DC Field | Value | Language |
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dc.contributor.author | Esposito J. | en |
dc.contributor.author | Proudman S.M. | en |
dc.contributor.author | Walker J. | en |
dc.contributor.author | Roddy J. | en |
dc.contributor.author | Zochling J. | en |
dc.contributor.author | Rabusa C. | en |
dc.contributor.author | Sahhar J. | en |
dc.contributor.author | Stevens W. | en |
dc.contributor.author | Brown Z. | en |
dc.contributor.author | Nikpour M. | en |
dc.date.accessioned | 2021-05-14T13:35:10Z | en |
dc.date.available | 2021-05-14T13:35:10Z | en |
dc.date.copyright | 2016 | en |
dc.date.created | 20161109 | en |
dc.date.issued | 2016-11-09 | en |
dc.identifier.citation | Arthritis Research and Therapy. 18 (1) (no pagination), 2016. Article Number: 246. Date of Publication: 22 Oct 2016. | en |
dc.identifier.issn | 1478-6354 | en |
dc.identifier.uri | https://repository.monashhealth.org/monashhealthjspui/handle/1/39756 | en |
dc.description.abstract | Background: In some rheumatic diseases such as systemic lupus erythematosus (SLE), low serum complement ('hypocomplementaemia') is a feature of active disease. However, the role of hypocomplementaemia in systemic sclerosis (SSc) is unknown. We sought to determine the frequency, clinical associations and relationship to disease activity of hypocomplementaemia in SSc. Method(s): The study included 1140 patients fulfilling the 2013 American College of Rheumatology criteria for SSc. Demographic, serological and clinical data, obtained prospectively through annual review, were analysed using univariable methods. Linear and logistic regression, together with generalised estimating equations, were used to determine the independent correlates of hypocomplementaemia ever, and at each visit, respectively. Result(s): At least one episode of hypocomplementaemia (low C3 and/or low C4) occurred in 24.1 % of patients over 1893 visits; these patients were more likely to be seropositive for anti-ribonucleoprotein (OR = 3.8, p = 0.002), anti-Ro (OR = 2.2, p = 0.002), anti-Smith (OR = 6.3, p = 0.035) and anti-phospholipid antibodies (OR = 1.4, p = 0.021) and were more likely to display features of overlap connective tissue disease, in particular polymyositis (OR = 16.0, p = 0.012). However, no association was found between hypocomplementaemia and either the European Scleroderma Study Group disease activity score or any of its component variables (including erythrocyte sedimentation rate) in univariate analysis. Among patients with SSc overlap disease features, those who were hypocomplementaemic were more likely to have digital ulcers (OR = 1.6, p = 0.034), tendon friction rubs (OR = 2.4, p = 0.037), forced vital capacity <80 % predicted (OR = 2.9, p = 0.008) and lower body mass index (BMI) (OR for BMI = 0.9, p < 0.0005) at that visit, all of which are features associated with SSc disease activity and/or severity. Conclusion(s): While hypocomplementaemia is not associated with disease activity in patients with non-overlap SSc, it is associated with some features of increased SSc disease activity in patients with overlap disease features.Copyright © 2016 The Author(s). | en |
dc.language | en | en |
dc.language | English | en |
dc.publisher | BioMed Central Ltd. (E-mail: info@biomedcentral.com) | en |
dc.relation.ispartof | Arthritis Research and Therapy | en |
dc.title | The association of low complement with disease activity in systemic sclerosis: A prospective cohort study. | en |
dc.type | Article | en |
dc.type.studyortrial | Observational study (cohort, case-control, cross sectional or survey) | - |
dc.identifier.doi | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1186/s13075-016-1147-2 | en |
dc.publisher.place | United Kingdom | en |
dc.identifier.pubmedid | 27770830 [http://www.ncbi.nlm.nih.gov/pubmed/?term=27770830] | en |
dc.identifier.source | 612858616 | en |
dc.identifier.institution | (Esposito, Nikpour) The University of Melbourne at St Vincent's Hospital (Melbourne), Department of Medicine, 41 Victoria Parade, Fitzroy, VIC 3065, Australia (Esposito, Brown, Stevens, Rabusa, Nikpour) St Vincent's Hospital (Melbourne), Department of Rheumatology, 41 Victoria Parade, Fitzroy, VIC 3065, Australia (Sahhar) Monash Health and Monash University, Department of Rheumatology, 246 Clayton Road, Clayton, VIC 3168, Australia (Sahhar) Monash Health and Monash University, Department of Medicine, 246 Clayton Road, Clayton, VIC 3168, Australia (Zochling) Menzies Institute for Medical Research, Department of Rheumatology, Private Bag 23, Hobart, TAS 7001, Australia (Roddy) Royal Perth Hospital, Department of Rheumatology, 197 Wellington Street, GPO Box X2213, Perth, WA 6001, Australia (Walker) Flinders Medical Centre, Department of Rheumatology, Flinders Drive, Bedford Park, SA 5042, Australia (Proudman) Royal Adelaide Hospital, Rheumatology Unit, North Terrace, Adelaide, SA 5000, Australia (Proudman) University of Adelaide, Discipline of Medicine, Adelaide, SA 5000, Australia | en |
dc.description.address | M. Nikpour, The University of Melbourne at St Vincent's Hospital (Melbourne), Department of Medicine, 41 Victoria Parade, Fitzroy, VIC 3065, Australia. E-mail: m.nikpour@unimelb.edu.au | en |
dc.description.publicationstatus | Embase | en |
dc.rights.statement | Copyright 2017 Elsevier B.V., All rights reserved. | en |
dc.subect.keywords | Complement Disease activity Systemic sclerosis | en |
dc.identifier.authoremail | Esposito J.; jamesge14@gmail.com Brown Z.; zoerenne.brown@gmail.com Stevens W.; wendy.stevens@svha.org.au Rabusa C.; candice.rabusa@svha.org.au Nikpour M.; m.nikpour@unimelb.edu.au Sahhar J.; josahhar@bigpond.com Zochling J.; jane.zochling@utas.edu.au Roddy J.; janet.roddy@health.wa.gov.au Walker J.; jenny.walker@health.sa.gov.au Proudman S.M.; sproudman@internode.on.net | en |
dc.description.grant | No: APP1071735 Organization: (NHMRC) *National Health and Medical Research Council* Country: Australia | en |
item.cerifentitytype | Publications | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | none | - |
item.openairetype | Article | - |
crisitem.author.dept | Rheumatology | - |
Appears in Collections: | Articles |
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