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Please use this identifier to cite or link to this item: https://repository.monashhealth.org/monashhealthjspui/handle/1/39847
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dc.contributor.authorAn Y.en
dc.contributor.authorChen S.en
dc.contributor.authorZhang X.en
dc.contributor.authorSu Y.en
dc.contributor.authorGuo J.en
dc.contributor.authorShen N.en
dc.contributor.authorMorand E.F.en
dc.contributor.authorYu D.en
dc.contributor.authorLi Z.en
dc.contributor.authorXu C.en
dc.contributor.authorHou Z.en
dc.contributor.authorLeong Y.A.en
dc.contributor.authorZhu L.en
dc.contributor.authorFeng J.en
dc.contributor.authorLi Y.en
dc.contributor.authorJia Y.en
dc.contributor.authorLi C.en
dc.contributor.authorLiu X.en
dc.contributor.authorYe H.en
dc.contributor.authorRen L.en
dc.contributor.authorLi R.en
dc.contributor.authorYao H.en
dc.contributor.authorHe J.en
dc.contributor.authorWei Y.en
dc.contributor.authorSun X.en
dc.contributor.authorChen Y.en
dc.contributor.authorDeng J.en
dc.contributor.authorJin Y.en
dc.contributor.authorGan Y.en
dc.contributor.authorHu X.en
dc.contributor.authorJia R.en
dc.date.accessioned2021-05-14T13:37:16Zen
dc.date.available2021-05-14T13:37:16Zen
dc.date.copyright2016en
dc.date.created20160920en
dc.date.issued2016-09-20en
dc.identifier.citationNature Medicine. 22 (9) (pp 991-993), 2016. Date of Publication: 01 Sep 2016.en
dc.identifier.issn1078-8956en
dc.identifier.urihttps://repository.monashhealth.org/monashhealthjspui/handle/1/39847en
dc.description.abstractSystemic lupus erythematosus (SLE) is a potentially life-threatening autoimmune disease characterized by altered balance of activity between effector and regulatory CD4+ T cells. The homeostasis of CD4+ T cell subsets is regulated by interleukin (IL)-2, and reduced production of IL-2 by T cells is observed in individuals with SLE. Here we report that treatment with low-dose recombinant human IL-2 selectively modulated the abundance of regulatory T (Treg) cells, follicular helper T (TFH) cells and IL-17-producing helper T (TH17) cells, but not TH1 or TH2 cells, accompanied by marked reductions of disease activity in patients with SLE.Copyright © 2016 Nature America, Inc. All rights reserved.en
dc.languageEnglishen
dc.languageenen
dc.publisherNature Publishing Group (Houndmills, Basingstoke, Hampshire RG21 6XS, United Kingdom)en
dc.relation.ispartofNature Medicineen
dc.titleLow-dose interleukin-2 treatment selectively modulates CD4+ T cell subsets in patients with systemic lupus erythematosus.en
dc.typeArticleen
dc.identifier.doihttp://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1038/nm.4148en
dc.publisher.placeUnited Kingdomen
dc.identifier.pubmedid27500725 [http://www.ncbi.nlm.nih.gov/pubmed/?term=27500725]en
dc.identifier.source611644281en
dc.identifier.institution(He, Zhang, Sun, Jin, Gan, Jia, Xu, Zhu, An, Jia, Li, Liu, Ye, Ren, Li, Yao, Li, Chen, Zhang, Su, Guo, Li) Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China (Wei, Hou, Feng, Yu) Laboratory of Immunology for Environment and Health, Shandong Analysis and Test Center, Shandong Academy of Sciences, Jinan, China (Chen, Hu, Leong, Yu) Laboratory for Molecular Immunomodulation, Department of Biochemistry and Molecular Biology, Infection and Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia (Deng, Shen, Yu) China-Australia Centre for Personalised Immunology, Shanghai Renji Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China (Morand, Yu) Centre for Inflammatory Diseases, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australiaen
dc.description.addressZ. Li, Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China. E-mail: li99@bjmu.edu.cnen
dc.description.publicationstatusEmbaseen
dc.rights.statementCopyright 2017 Elsevier B.V., All rights reserved.en
dc.identifier.authoremailLi Z.; li99@bjmu.edu.cn Yu D.; di.yu@monash.eduen
dc.description.grantNo: 31530020 Organization: (NSFC) *National Natural Science Foundation of China* No: 31570880 Organization: (NSFC) *National Natural Science Foundation of China* No: 81373117 Organization: (NSFC) *National Natural Science Foundation of China* No: 81429003 Organization: (NSFC) *National Natural Science Foundation of China* No: 81471601 Organization: (NSFC) *National Natural Science Foundation of China* No: GNT1085509 Organization: (NHMRC) *National Health and Medical Research Council*en
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.grantfulltextnone-
item.fulltextNo Fulltext-
crisitem.author.deptRheumatology-
crisitem.author.deptCentre for Inflammatory Diseases at Monash Health-
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