Please use this identifier to cite or link to this item:
https://repository.monashhealth.org/monashhealthjspui/handle/1/39847
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | An Y. | en |
dc.contributor.author | Chen S. | en |
dc.contributor.author | Zhang X. | en |
dc.contributor.author | Su Y. | en |
dc.contributor.author | Guo J. | en |
dc.contributor.author | Shen N. | en |
dc.contributor.author | Morand E.F. | en |
dc.contributor.author | Yu D. | en |
dc.contributor.author | Li Z. | en |
dc.contributor.author | Xu C. | en |
dc.contributor.author | Hou Z. | en |
dc.contributor.author | Leong Y.A. | en |
dc.contributor.author | Zhu L. | en |
dc.contributor.author | Feng J. | en |
dc.contributor.author | Li Y. | en |
dc.contributor.author | Jia Y. | en |
dc.contributor.author | Li C. | en |
dc.contributor.author | Liu X. | en |
dc.contributor.author | Ye H. | en |
dc.contributor.author | Ren L. | en |
dc.contributor.author | Li R. | en |
dc.contributor.author | Yao H. | en |
dc.contributor.author | He J. | en |
dc.contributor.author | Wei Y. | en |
dc.contributor.author | Sun X. | en |
dc.contributor.author | Chen Y. | en |
dc.contributor.author | Deng J. | en |
dc.contributor.author | Jin Y. | en |
dc.contributor.author | Gan Y. | en |
dc.contributor.author | Hu X. | en |
dc.contributor.author | Jia R. | en |
dc.date.accessioned | 2021-05-14T13:37:16Z | en |
dc.date.available | 2021-05-14T13:37:16Z | en |
dc.date.copyright | 2016 | en |
dc.date.created | 20160920 | en |
dc.date.issued | 2016-09-20 | en |
dc.identifier.citation | Nature Medicine. 22 (9) (pp 991-993), 2016. Date of Publication: 01 Sep 2016. | en |
dc.identifier.issn | 1078-8956 | en |
dc.identifier.uri | https://repository.monashhealth.org/monashhealthjspui/handle/1/39847 | en |
dc.description.abstract | Systemic lupus erythematosus (SLE) is a potentially life-threatening autoimmune disease characterized by altered balance of activity between effector and regulatory CD4+ T cells. The homeostasis of CD4+ T cell subsets is regulated by interleukin (IL)-2, and reduced production of IL-2 by T cells is observed in individuals with SLE. Here we report that treatment with low-dose recombinant human IL-2 selectively modulated the abundance of regulatory T (Treg) cells, follicular helper T (TFH) cells and IL-17-producing helper T (TH17) cells, but not TH1 or TH2 cells, accompanied by marked reductions of disease activity in patients with SLE.Copyright © 2016 Nature America, Inc. All rights reserved. | en |
dc.language | English | en |
dc.language | en | en |
dc.publisher | Nature Publishing Group (Houndmills, Basingstoke, Hampshire RG21 6XS, United Kingdom) | en |
dc.relation.ispartof | Nature Medicine | en |
dc.title | Low-dose interleukin-2 treatment selectively modulates CD4+ T cell subsets in patients with systemic lupus erythematosus. | en |
dc.type | Article | en |
dc.identifier.doi | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1038/nm.4148 | en |
dc.publisher.place | United Kingdom | en |
dc.identifier.pubmedid | 27500725 [http://www.ncbi.nlm.nih.gov/pubmed/?term=27500725] | en |
dc.identifier.source | 611644281 | en |
dc.identifier.institution | (He, Zhang, Sun, Jin, Gan, Jia, Xu, Zhu, An, Jia, Li, Liu, Ye, Ren, Li, Yao, Li, Chen, Zhang, Su, Guo, Li) Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China (Wei, Hou, Feng, Yu) Laboratory of Immunology for Environment and Health, Shandong Analysis and Test Center, Shandong Academy of Sciences, Jinan, China (Chen, Hu, Leong, Yu) Laboratory for Molecular Immunomodulation, Department of Biochemistry and Molecular Biology, Infection and Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia (Deng, Shen, Yu) China-Australia Centre for Personalised Immunology, Shanghai Renji Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China (Morand, Yu) Centre for Inflammatory Diseases, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia | en |
dc.description.address | Z. Li, Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China. E-mail: li99@bjmu.edu.cn | en |
dc.description.publicationstatus | Embase | en |
dc.rights.statement | Copyright 2017 Elsevier B.V., All rights reserved. | en |
dc.identifier.authoremail | Li Z.; li99@bjmu.edu.cn Yu D.; di.yu@monash.edu | en |
dc.description.grant | No: 31530020 Organization: (NSFC) *National Natural Science Foundation of China* No: 31570880 Organization: (NSFC) *National Natural Science Foundation of China* No: 81373117 Organization: (NSFC) *National Natural Science Foundation of China* No: 81429003 Organization: (NSFC) *National Natural Science Foundation of China* No: 81471601 Organization: (NSFC) *National Natural Science Foundation of China* No: GNT1085509 Organization: (NHMRC) *National Health and Medical Research Council* | en |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.openairetype | Article | - |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
crisitem.author.dept | Rheumatology | - |
crisitem.author.dept | Centre for Inflammatory Diseases at Monash Health | - |
Appears in Collections: | Articles |
Items in Monash Health Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.