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Please use this identifier to cite or link to this item: https://repository.monashhealth.org/monashhealthjspui/handle/1/39928
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dc.contributor.authorWallace E.M.en
dc.contributor.authorGurusinghe S.en
dc.contributor.authorMockler J.C.en
dc.contributor.authorLim R.en
dc.contributor.authorRahman R.en
dc.contributor.authorMurthi P.en
dc.contributor.authorSingh H.en
dc.date.accessioned2021-05-14T13:39:10Zen
dc.date.available2021-05-14T13:39:10Zen
dc.date.copyright2016en
dc.date.created20170117en
dc.date.issued2017-01-17en
dc.identifier.citationPregnancy Hypertension. 6 (4) (pp 259-262), 2016. Date of Publication: 01 Oct 2016.en
dc.identifier.issn2210-7789en
dc.identifier.urihttps://repository.monashhealth.org/monashhealthjspui/handle/1/39928en
dc.description.abstractHydroxychloroquine is an anti-malarial drug which, due to its anti-inflammatory and immunomodulatory effects, is widely used for the treatment of autoimmune diseases. In a model of systemic lupus erythematosus hydroxychloroquine has been shown to exert protective endothelial effects. In this study, we aimed to investigate whether hydroxychloroquine was endothelial protective in an in vitro model of TNF-alpha and preeclamptic serum induced dysfunction. We showed that hydroxychloroquine significantly reduced the production of TNF-alpha and preeclamptic serum induced endothelin-1 (ET-1). Hydroxychloroquine also significantly mitigated TNF-alpha induced impairment of angiogenesis. These findings support the further assessment of hydroxychloroquine as an adjuvant therapy in preeclampsia.Copyright © 2016 International Society for the Study of Hypertension in Pregnancyen
dc.languageEnglishen
dc.languageenen
dc.publisherElsevier B.V.en
dc.relation.ispartofPregnancy Hypertensionen
dc.titleThe effects of hydroxychloroquine on endothelial dysfunction.en
dc.typeArticleen
dc.identifier.affiliationObstetrics and Gynaecology (Monash Women's)-
dc.identifier.doihttp://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1016/j.preghy.2016.09.001en
dc.publisher.placeNetherlandsen
dc.identifier.orcidRahman, Rahana; ORCID: http://orcid.org/0000-0003-4161-6461en
dc.identifier.pubmedid27939463 [http://www.ncbi.nlm.nih.gov/pubmed/?term=27939463]en
dc.identifier.source613772811en
dc.identifier.institution(Rahman, Singh, Gurusinghe, Mockler, Lim, Wallace) The Ritchie Centre, Hudson Institute of Medical Research, 27-31 Wright Street, Clayton 3168, Melbourne, VIC, Australia (Rahman, Gurusinghe, Mockler, Wallace) Department of Obstetrics and Gynaecology, School of Clinical Sciences, Monash University, Monash Medical Centre, 246 Clayton Road, Clayton 3168, Melbourne, VIC, Australia (Rahman) Department of Obstetrics and Gynaecology, Faculty of Medicine, National University of Malaysia, Jalan Yaacob Latiff, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur, Malaysia (Murthi) Department of Medicine, School of Clinical Sciences, Monash University, Monash Medical Centre, 246 Clayton Road, Clayton 3168, Melbourne, VIC, Australiaen
dc.description.addressE.M. Wallace, Department of Obstetrics and Gynaecology, Monash University, Monash Medical Centre, Level 5, 246 Clayton Road, Clayton, VIC 3168, Australia. E-mail: euan.wallace@monash.eduen
dc.description.publicationstatusEmbaseen
dc.rights.statementCopyright 2017 Elsevier B.V., All rights reserved.en
dc.subect.keywordsEndothelial dysfunction Endothelin-1 Hydroxychloroquine Preeclampsia Preeclamptic serum TNF-alphaen
dc.identifier.authoremailWallace E.M.; euan.wallace@monash.eduen
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.openairetypeArticle-
crisitem.author.deptObstetrics and Gynaecology (Monash Women's)-
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