Oral acanthosis nigricans and leser-trelat sign in metastatic serous ovarian carcinoma: Case report and review of literature.

Abstract

A 69-year-old lady presented with 12-month history of painful oral sensation and a gradual onset of abdominal bloating associated with constipation. Assessment by the dental team did not lead to any specific diagnosis. She was then referred to the dermatology unit for assessment of her generalised pruritus and eruptive seborrhoeic keratoses. Physical examination revealed multiple tiny skincoloured seborrhoeic keratoses especially on her inner thighs, thickened fissured tongue and extensive acanthosis nigricans-like papillomatous changes on her buccal mucosa. Raised tumour markers and further imaging then led to the diagnosis of high grade metastatic serous ovarian carcinoma. This is the first case report of Leser-Trelet sign and malignant oral acanthosis nigrican associated with ovarian carcinoma. This case highlights the rarity of the 2 paraneoplastic phenomena and the under-recognition of these important signs by general medical and dental professionals1,2.