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DC Field | Value | Language |
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dc.contributor.author | Bird R. | en |
dc.contributor.author | Tam C. | en |
dc.contributor.author | Kellner S. | en |
dc.contributor.author | Grigg A. | en |
dc.contributor.author | Motum P. | en |
dc.contributor.author | Bentley M. | en |
dc.contributor.author | Opat S. | en |
dc.contributor.author | Grigoriadis G. | en |
dc.contributor.author | Szer J. | en |
dc.contributor.author | Banerjee A. | en |
dc.contributor.author | Mifsud N.A. | en |
dc.contributor.author | Forsyth C. | en |
dc.date.accessioned | 2021-05-14T13:59:09Z | en |
dc.date.available | 2021-05-14T13:59:09Z | en |
dc.date.copyright | 2015 | en |
dc.date.created | 20150225 | en |
dc.date.issued | 2015-02-25 | en |
dc.identifier.citation | British Journal of Haematology. 168 (4) (pp 576-582), 2015. Date of Publication: 01 Feb 2015. | en |
dc.identifier.issn | 0007-1048 | en |
dc.identifier.uri | https://repository.monashhealth.org/monashhealthjspui/handle/1/40861 | en |
dc.description.abstract | Summary: The myelodysplastic syndromes (MDS) are a group of disorders characterized by ineffective haematopoiesis, bone marrow dysplasia and cytopenias. Failure of red cell production often results in transfusion dependency with subsequent iron loading requiring iron chelation in lower risk patients. Consistent with previous reports, we have observed haematopoietic improvement in a cohort of patients treated with the oral iron chelator deferasirox (DFX). It has been postulated that MDS patients have a pro-inflammatory bone marrow environment with increased numbers of activated T cells producing elevated levels of tumour necrosis factor (TNF), which is detrimental to normal haematopoiesis. We demonstrate that DFX inhibits nuclear factor (NF)-kappaB dependent transcription without affecting its proximal activation, resulting in reduced TNF production from T cells stimulated in vitro. These results suggest that the haematopoietic improvement observed in DFX-treated patients may reflect an anti-inflammatory effect, mediated through inhibition of the transcription factor NF-kappaB and support the therapeutic targeting of this pathway, which is aberrantly activated in a large proportion of haematological malignancies.Copyright © 2014 John Wiley & Sons Ltd. | en |
dc.language | English | en |
dc.language | en | en |
dc.publisher | Blackwell Publishing Ltd (E-mail: customerservices@oxonblackwellpublishing.com) | en |
dc.relation.ispartof | British Journal of Haematology | en |
dc.title | The oral iron chelator deferasirox inhibits NF-kappaB mediated gene expression without impacting on proximal activation: Implications for myelodysplasia and aplastic anaemia. | en |
dc.type | Article | en |
dc.type.studyortrial | Observational study (cohort, case-control, cross sectional or survey) | - |
dc.identifier.doi | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1111/bjh.13151 | en |
dc.publisher.place | United Kingdom | en |
dc.identifier.pubmedid | 25271366 [http://www.ncbi.nlm.nih.gov/pubmed/?term=25271366] | en |
dc.identifier.source | 600329833 | en |
dc.identifier.institution | (Banerjee, Grigoriadis) Centre for Cancer Research, MIMR-PHI Institute of Medical Research, Clayton, VIC, Australia (Banerjee, Grigoriadis) Centre for Inflammatory Diseases, Monash University, Clayton, VIC, Australia (Mifsud) Departments of Medicine and Allergy, Immunology and Respiratory Medicine, Monash University, Clayton, VIC, Australia (Bird) Haematology, Princess Alexandra Hospital, Brisbane, QLD, Australia (Bird) School of Medicine, Griffith University, Brisbane, QLD, Australia (Forsyth) Haematology, Jarrett Street Specialist Centre, North Gosford, NSW, Australia (Szer) Clinical Haematology, Royal Melbourne Hospital, Melbourne, VIC, Australia (Tam) Haematology, Peter MacCallum Cancer Centre, East Melbourne, VIC, Australia (Kellner) Haematology, Cotton Tree Specialist Centre, Cotton Tree, QLD, Australia (Grigg) Department of Clinical Haematology, Austin Hospital, Heidelberg, VIC, Australia (Motum) Haematology Department, Liverpool Hospital, Liverpool, NSW, Australia (Bentley) Haematology, Queensland Haematology and Oncology Group, Brisbane, QLD, Australia (Opat, Grigoriadis) Clinical Haematology, Monash Health, Clayton, VIC, Australia (Grigoriadis) Department of Haematology, Alfred Health, Melbourne, Australia | en |
dc.description.address | A. Banerjee, MIMR-PHI Institute, Centre for Cancer Research, 27-31 Wright Street, Clayton, VIC 3168, Australia | en |
dc.description.publicationstatus | Embase | en |
dc.rights.statement | Copyright 2015 Elsevier B.V., All rights reserved. | en |
dc.subect.keywords | Aplastic anaemia Biochemistry Blood diseases Chelation Myeloid function and development | en |
dc.identifier.authoremail | Banerjee A.; ashish.banerjee@monash.edu Grigoriadis G.; george.grigoriadis@monash.edu | en |
item.cerifentitytype | Publications | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | none | - |
item.openairetype | Article | - |
crisitem.author.dept | Haematology | - |
crisitem.author.dept | Haematology | - |
Appears in Collections: | Articles |
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