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https://repository.monashhealth.org/monashhealthjspui/handle/1/40958| Title: | Influenza vaccine effectiveness against hospitalisation with influenza in adults in Australia in 2014. | Authors: | Irving L.;Waterer G.;Dwyer D.E.;Macartney K.;Blyth C.;Kotsimbos T.;Kelly P.M.;Wark P.;Hunter C.;Hewagama S.;Friedman N.D.;Korman T. ;Simpson G.;Upham J.W.;Bowler S.;Senenayake S.-J.;Holmes M.;Brown S.G.A.;Cheng A.C. | Monash Health Department(s): | Infectious Diseases and Clinical Microbiology | Institution: | (Cheng) Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, VIC, Australia (Cheng) Infection Prevention and Healthcare Epidemiology Unit, Alfred Health, Melbourne, VIC, Australia (Kotsimbos) Department of Allergy, Immunology and Respiratory Medicine, Alfred Health and Monash University, Melbourne, VIC, Australia (Kelly) ACT Health Directorate, Canberra, Australia (Wark) University of Newcastle, John Hunter Hospital, Newcastle, Australia (Hunter) Royal Hobart Hospital, Hobart, Australia (Hewagama) AliceSprings Hospital, Alice Springs, Australia (Friedman) Barwon Health, Geelong, Australia (Korman) Monash Health, Monash University, Mel-bourne, VIC, Australia (Simpson) Cairns Base Hospital, Cairns, Australia (Upham) Princess Alexandra Hospital, The University of Queensland, StLucia, Australia (Bowler) Mater Hospitals, South Brisbane, Australia (Senenayake) Australian National University, The Canberra Hospital, Canberra, Australia (Holmes) Royal Adelaide Hospital, University of Adelaide, Adelaide, Australia (Irving) Royal Melbourne Hospital, University of Melbourne, Mel-bourne, Australia (Brown) University of Western Australia, Royal PerthHospital, Perth, Australia (Waterer) University of Western Australia, RoyalPerth Hospital, University of Western Australia, Perth, Australia (Dwyer) Westmead Hospital, University of Sydney, Sydney, Australia (Macartney) National Centre for Immunisation Resesarch and Surveillance, University of Syd-ney, Sydney, Australia (Blyth) Princess Margaret Hospital, University ofWestern Australia, Perth, Australia | Issue Date: | 7-Feb-2016 | Copyright year: | 2015 | Publisher: | Elsevier Ltd | Place of publication: | United Kingdom | Publication information: | Vaccine. 33 (51) (pp 7352-7356), 2015. Date of Publication: 16 Dec 2015. | Journal: | Vaccine | Abstract: | We provide estimates of the influenza vaccine protection against hospitalisation with laboratory-confirmed influenza in the 2014 Australian season where the A/H1N1/pdm09 strain predominated. This was performed using a case-test negative study design as part of a national sentinel surveillance system in Australia. Vaccine effectiveness was estimated as (1-OR). x. 100% where the odds ratio of vaccination in cases vs test negative participants was estimated from a conditional logistic regression. Between April and November, 1692 adult patients were admitted with laboratory-confirmed influenza. Vaccine effectiveness was estimated from 1283 patients with influenza and 1116 test negative patients where vaccination status was ascertained. Vaccination was associated with a reduction in the risk of hospitalisation with influenza of 51.5% (95% CI: 41.6%, 59.7%) in all patients, and a reduction of 50.7% (95% CI: 40.1%, 59.3%) in the target population for vaccination. We estimate that the influenza vaccine was moderately protective against hospitalisation with laboratory-confirmed influenza during the 2014 influenza season in Australia.Copyright © 2015 Elsevier Ltd. | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1016/j.vaccine.2015.10.016 | PubMed URL: | 26529066 [http://www.ncbi.nlm.nih.gov/pubmed/?term=26529066] | ISSN: | 0264-410X | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/40958 | Type: | Article |
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