Please use this identifier to cite or link to this item:
https://repository.monashhealth.org/monashhealthjspui/handle/1/41242
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Malikiwi A. | en |
dc.contributor.author | Tan K. | en |
dc.contributor.author | Sehgal A. | en |
dc.contributor.author | Menahem S. | en |
dc.date.accessioned | 2021-05-14T14:07:48Z | en |
dc.date.available | 2021-05-14T14:07:48Z | en |
dc.date.copyright | 2015 | en |
dc.date.created | 20151208 | en |
dc.date.issued | 2015-12-09 | en |
dc.identifier.citation | Heart Lung and Circulation. Conference: Cardiac Society of Australia and New Zealand Annual Scientific Meeting and the International Society for Heart Research Australasian Section Annual Scientific Meeting 2015. Melbourne, VIC Australia. Conference Publication: (var.pagings). 24 (SUPPL. 3) (pp S422), 2015. Date of Publication: 2015. | en |
dc.identifier.issn | 1443-9506 | en |
dc.identifier.uri | https://repository.monashhealth.org/monashhealthjspui/handle/1/41242 | en |
dc.description.abstract | Objective: Pulmonary hypertension and right ventricular performance and not left sided dysfunction are highlighted in the cardiovascular effects of bronchopulmonary dysplasia (BPD). Our study objective was to assess left sided vascular and cardiac indices which may reflect elevated systemic afterload and resultant pulmonary venous back pressure and consider possible therapeutic options. Method(s): Vascular biophysical and cardiac parameters were measured by ultrasonography in 20 infants with severe BPD and 20 healthy term infants. Result(s): Maximum aortic thickness was greater in BPD infants (827.5+/-163 vs 657.5+/-67.8 m, p<0.0001). Biophysical arterial markers [stiffness index (3.4+/- 0.6 vs 2.3+/-0.4, p<0.0001), input impedance (574.4+/-127.4 vs 328.1+/-113.2 dynes.s/cm5, p<0.0001) and circumferential wall tension (23126.8+/-2395 vs 20613.8+/-2242.4 d/cm, p=0.001)] were elevated. Left ventricular diastolic dysfunction [(elevated E/A ratio (0.9+/-0.09 vs 1.07+/-0.07, p<0.0001), prolonged E wave deceleration time (60.4+/-7 vs 75.6+/-7.9ms, p<0.0001), Isovolumic relaxation time (54 (49, 57) vs 68 (67, 71.7) ms, p<0.0001) and reduced pulmonary venousflow(VTI, 8.2+/-0.3 vs 5.4+/-0.4cm, p<0.0001) were noted. Themeanvelocity of circumferential fibre shortening (3+/-0.64 vs 1.7+/-0.42 circ/sec, p<0.0001) and Tei index (0.27+/-0.05 vs 0.33+/-0.05, p=0.001) was altered. Conclusion(s): Increased downstream stiffness, reduced myocardial contractility and elevated atrial/pulmonary venous back pressure may lead to pulmonary venous congestion and continued need for respiratory support. Systemic afterload reduction as a therapeutic option merits prospective analysis. | en |
dc.language | en | en |
dc.language | English | en |
dc.publisher | Elsevier Ltd | en |
dc.title | A new look at bronchopulmonary dysplasia: Role of systemic vascular & cardiac function in therapeutic options. | en |
dc.type | Conference Abstract | en |
dc.identifier.doi | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1016/j.hlc.2015.06.721 | en |
local.date.conferencestart | 2015-08-13 | en |
dc.identifier.source | 72103531 | en |
dc.identifier.institution | (Sehgal, Malikiwi, Tan) Monash Newborn, Monash Children's Hospital, Melbourne, VIC, Australia (Tan) Department of Paediatrics, Monash University, Melbourne, VIC, Australia (Menahem) Emeritus Head, Paediatric and Fetal Cardiac Units, Monash Medical Centre, Melbourne, VIC, Australia | en |
dc.description.address | A. Sehgal, Monash Newborn, Monash Children's Hospital, Melbourne, VIC, Australia | en |
dc.description.publicationstatus | CONFERENCE ABSTRACT | en |
local.date.conferenceend | 2015-08-16 | en |
dc.rights.statement | Copyright 2015 Elsevier B.V., All rights reserved. | en |
dc.identifier.affiliationext | (Tan) Department of Paediatrics, Monash University, Melbourne, VIC, Australia | - |
dc.identifier.affiliationmh | (Peverill) Monash Cardiovascular Research Centre, MonashHeart, Monash Health and Monash University Department of Medicine (MMC), Clayton, VIC, Australia | - |
dc.identifier.affiliationmh | (Bowden) Thalassaemia Service, Monash Health, Clayton, VIC, Australia | - |
item.openairetype | Conference Abstract | - |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Paediatric - Neonatal (Monash Newborn) | - |
crisitem.author.dept | Hudson Institute - The Ritchie Centre | - |
crisitem.author.dept | Paediatric - Neonatal (Monash Newborn) | - |
crisitem.author.dept | Paediatric - Cardiology | - |
Appears in Collections: | Conferences |
Items in Monash Health Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.