Please use this identifier to cite or link to this item:
https://repository.monashhealth.org/monashhealthjspui/handle/1/42598
Title: | Early pancreas allograft thrombosis. | Authors: | Saunder A.C.;Mulley W.R.;Ramessur Chandran S.;Kanellis J.;Polkinghorne K.R. | Institution: | (Ramessur Chandran, Kanellis, Polkinghorne, Saunder, Mulley) Department of Nephrology, Monash Medical Centre, Clayton, VIC, Australia (Kanellis, Polkinghorne, Mulley) Department of Medicine, Monash University, Clayton, VIC, Australia (Saunder) Department of Surgery, Monash Medical Centre, Clayton, VIC, Australia | Issue Date: | 18-Jun-2013 | Copyright year: | 2013 | Publisher: | Blackwell Publishing Ltd (E-mail: customerservices@oxonblackwellpublishing.com) | Place of publication: | United Kingdom | Publication information: | Clinical Transplantation. 27 (3) (pp 410-416), 2013. Date of Publication: May/June 2013. | Journal: | Clinical Transplantation | Abstract: | Objectives: To determine factors associated with early pancreatic allograft thrombosis (EPAT). Thrombosis is the leading non-immunological cause of early pancreatic allograft failure. Multiple risk factors have been postulated. We hypothesized that recipient perioperative hypotension was a major risk factor and evaluated the correlation of this and other parameters with EPAT. Method(s): We retrospectively reviewed the records of the 118 patients who received a pancreatic allograft at our center between October 1992 and January 2010. Multiple donor and recipient parameters were analyzed as associates of EPAT by univariate and multivariate analysis. Result(s): There were 12 episodes of EPAT, resulting in an incidence of 10.2%. On univariate analysis, EPAT was associated with perioperative hypotension, vasopressor use, and neuropathy in the recipient (p <= 0.04 for all). On multivariate analysis corrected for age, sex, and peripheral vascular disease, only vasopressor use retained a significant association with EPAT with a hazard ratio of 8.74 (CI 1.11-68.9, p = 0.04). Factors associated with vasopressor use included recipient ischemic heart disease, peripheral vascular disease, retinopathy or neuropathy, and any surgical complication. Conclusion(s): Significant hypotension, measured by the need for perioperative vasopressor use was associated with EPAT, suggesting that maintenance of higher perfusion pressures may avoid this complication. © 2013 John Wiley & Sons A/S. | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1111/ctr.12105 | PubMed URL: | 23495654 [http://www.ncbi.nlm.nih.gov/pubmed/?term=23495654] | ISSN: | 0902-0063 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/42598 | Type: | Article |
Appears in Collections: | Articles |
Show full item record
Items in Monash Health Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.