Please use this identifier to cite or link to this item: https://repository.monashhealth.org/monashhealthjspui/handle/1/47423
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dc.contributor.authorSchaefer J.-
dc.contributor.authorDavey M.J.-
dc.contributor.authorNixon G.M.-
dc.date.accessioned2022-05-03T03:18:22Z-
dc.date.available2022-05-03T03:18:22Z-
dc.date.copyright2022-
dc.date.issued2022-04-07en
dc.identifier.citationJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine. 18(4) (pp 1055-1061), 2022. Date of Publication: 01 Apr 2022.-
dc.identifier.urihttps://repository.monashhealth.org/monashhealthjspui/handle/1/47423-
dc.description.abstractSTUDY OBJECTIVES: Studies of sleep-disordered breathing (SDB) in children with Prader-Willi syndrome (PWS) have focused on early childhood and growth hormone (GH)-naive children, but little is known about older children, including those on long-term GH therapy. This study aimed to describe the nature and prevalence of SDB in school-aged children with PWS in the growth hormone era. METHOD(S): This retrospective single-center chart review included children aged 6-18 years with PWS who had overnight polysomnography not involving respiratory support over 5 years (2012-2017). The main outcome measures were the presence of obstructive sleep apnea, central sleep apnea, or hypoventilation defined by an elevated transcutaneous partial pressure of carbon dioxide (TcPCO2) as per standard pediatric criteria. RESULT(S): Seventeen children (8 males; median age 11.6 years, range 6.6-16.1 years) were included. Fifteen demonstrated SDB of different types: central sleep apnea (18%), obstructive sleep apnea (24%), both obstructive and central sleep apnea (29%), or hypoventilation without obstructive or central sleep apnea (18%). Twelve (71%) children had evidence of hypoventilation. Those with hypoventilation had a higher central apnea-hypopnea index but no difference in the obstructive apnea-hypopnea index, age, sex, growth parameters, or the presence of scoliosis or sleep-related symptoms compared with those without hypoventilation. CONCLUSION(S): Sleep-related hypoventilation is common in school-aged children with PWS. The presence of central sleep apnea, including the quantification of central hypopneas, but not obstructive sleep apnea or clinical factors, predicted the presence of hypoventilation. Long-term polysomnography surveillance in children with PWS should include identification of central hypopneas and measurement of continuous pCO2. CITATION: Schaefer J, Davey MJ, Nixon GM. Sleep-disordered breathing in school-aged children with Prader-Willi syndrome. J Clin Sleep Med. 2022;18(4):1055-1061.Copyright © 2022 American Academy of Sleep Medicine.-
dc.publisherNLM (Medline)-
dc.relation.ispartofJournal of Clinical Sleep Medicine-
dc.subject.meshcentral sleep apnea syndrome-
dc.subject.meshpolysomnography-
dc.subject.meshPrader Willi syndrome-
dc.subject.meshsleep disordered breathing-
dc.titleSleep-disordered breathing in school-aged children with Prader-Willi syndrome.-
dc.typeArticle-
dc.identifier.affiliationPaediatric - Respiratory and Sleep (Melbourne Children's Sleep Centre)-
dc.identifier.doihttp://monash.idm.oclc.org/login?url=https://dx.doi.org/10.5664/jcsm.9788-
dc.publisher.placeUnited States-
dc.identifier.pubmedid34870583 [https://www.ncbi.nlm.nih.gov/pubmed/?term=34870583]-
dc.identifier.institution(Schaefer, Davey, Nixon) Melbourne Children's Sleep Centre, Monash Children's Hospital, Monash Health, Melbourne, Australia-
dc.identifier.institution(Davey, Nixon) Department of Pediatrics, Monash University, Melbourne, Australia-
dc.identifier.affiliationmh(Schaefer, Davey, Nixon) Melbourne Children's Sleep Centre, Monash Children's Hospital, Monash Health, Melbourne, Australia-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
crisitem.author.deptPaediatric - Respiratory and Sleep (Melbourne Children's Sleep Centre)-
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