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DC Field | Value | Language |
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dc.contributor.author | Rowntree L.C. | - |
dc.contributor.author | Audsley J. | - |
dc.contributor.author | Allen L.F. | - |
dc.contributor.author | McQuilten H.A. | - |
dc.contributor.author | Hagen R.R. | - |
dc.contributor.author | Chaurasia P. | - |
dc.contributor.author | Petersen J. | - |
dc.contributor.author | Littler D.R. | - |
dc.contributor.author | Tan H.-X. | - |
dc.contributor.author | Murdiyarso L. | - |
dc.contributor.author | Habel J.R. | - |
dc.contributor.author | Foo I.J.H. | - |
dc.contributor.author | Zhang W. | - |
dc.contributor.author | Ten Berge E.R.V. | - |
dc.contributor.author | Ganesh H. | - |
dc.contributor.author | Kaewpreedee P. | - |
dc.contributor.author | Lee K.W.K. | - |
dc.contributor.author | Cheng S.M.S. | - |
dc.contributor.author | Kwok J.S.Y. | - |
dc.contributor.author | Jayasinghe D. | - |
dc.contributor.author | Gras S. | - |
dc.contributor.author | Juno J.A. | - |
dc.contributor.author | Wheatley A.K. | - |
dc.contributor.author | Kent S.J. | - |
dc.contributor.author | Rossjohn J. | - |
dc.contributor.author | Cheng, Allen C. | - |
dc.contributor.author | Kotsimbos T.C. | - |
dc.contributor.author | Trubiano J.A. | - |
dc.contributor.author | Holmes N.E. | - |
dc.contributor.author | Pang Chan K.K. | - |
dc.contributor.author | Hui D.S.C. | - |
dc.contributor.author | Peiris M. | - |
dc.contributor.author | Poon L.L.M. | - |
dc.contributor.author | Lewin S.R. | - |
dc.contributor.author | Doherty P.C. | - |
dc.contributor.author | Thevarajan I. | - |
dc.contributor.author | Valkenburg S.A. | - |
dc.contributor.author | Kedzierska K. | - |
dc.contributor.author | Nguyen T.H.O. | - |
dc.date.accessioned | 2024-10-01T03:48:22Z | - |
dc.date.available | 2024-10-01T03:48:22Z | - |
dc.date.copyright | 2024 | - |
dc.date.issued | 2024-09-24 | en |
dc.identifier.citation | Proceedings of the National Academy of Sciences of the United States of America. 121(39) (pp e2411428121), 2024. Date of Publication: 24 Sep 2024. | - |
dc.identifier.uri | https://repository.monashhealth.org/monashhealthjspui/handle/1/52539 | - |
dc.description.abstract | Long COVID occurs in a small but important minority of patients following COVID-19, reducing quality of life and contributing to healthcare burden. Although research into underlying mechanisms is evolving, immunity is understudied. SARS-CoV-2-specific T cell responses are of key importance for viral clearance and COVID-19 recovery. However, in long COVID, the establishment and persistence of SARS-CoV-2-specific T cells are far from clear, especially beyond 12 mo postinfection and postvaccination. We defined ex vivo antigen-specific B cell and T cell responses and their T cell receptors (TCR) repertoires across 2 y postinfection in people with long COVID. Using 13 SARS-CoV-2 peptide-HLA tetramers, spanning 11 HLA allotypes, as well as spike and nucleocapsid probes, we tracked SARS-CoV-2-specific CD8+ and CD4+ T cells and B-cells in individuals from their first SARS-CoV-2 infection through primary vaccination over 24 mo. The frequencies of ORF1a- and nucleocapsid-specific T cells and B cells remained stable over 24 mo. Spike-specific CD8+ and CD4+ T cells and B cells were boosted by SARS-CoV-2 vaccination, indicating immunization, in fully recovered and people with long COVID, altered the immunodominance hierarchy of SARS-CoV-2 T cell epitopes. Meanwhile, influenza-specific CD8+ T cells were stable across 24 mo, suggesting no bystander-activation. Compared to total T cell populations, SARS-CoV-2-specific T cells were enriched for central memory phenotype, although the proportion of central memory T cells decreased following acute illness. Importantly, TCR repertoire composition was maintained throughout long COVID, including postvaccination, to 2 y postinfection. Overall, we defined ex vivo SARS-CoV-2-specific B cells and T cells to understand primary and recall responses, providing key insights into antigen-specific responses in people with long COVID. | - |
dc.relation.ispartof | Proceedings of the National Academy of Sciences of the United States of America | - |
dc.subject.mesh | coronavirus disease 2019 | - |
dc.subject.mesh | immunology | - |
dc.subject.mesh | long COVID | - |
dc.subject.mesh | metabolism | - |
dc.subject.mesh | Severe acute respiratory syndrome coronavirus | - |
dc.title | SARS-CoV-2-specific CD8+ T cells from people with long COVID establish and maintain effector phenotype and key TCR signatures over 2 years. | - |
dc.type | Article | - |
dc.identifier.affiliation | Infectious Diseases and Clinical Microbiology | - |
dc.identifier.affiliation | Monash University - School of Clinical Sciences at Monash Health | - |
dc.type.studyortrial | Observational study (cohort, case-control, cross sectional, or survey) | - |
dc.identifier.doi | http://monash.idm.oclc.org/login?url=https://dx.doi.org/10.1073/pnas.2411428121 | - |
dc.publisher.place | United States | - |
dc.identifier.pubmedid | 39284068 [https://www.ncbi.nlm.nih.gov/pubmed/?term=39284068] | - |
dc.identifier.institution | (Rowntree, Allen, McQuilten, Hagen, Tan, Murdiyarso, Habel, Foo, Zhang, Ten Berge, Juno, Wheatley, Kent, Doherty, Valkenburg, Kedzierska, Nguyen) Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia | - |
dc.identifier.institution | (Audsley, Ganesh, Trubiano, Lewin, Thevarajan) Department of Infectious Diseases, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia | - |
dc.identifier.institution | (Chaurasia, Petersen, Littler, Gras, Rossjohn) Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia | - |
dc.identifier.institution | (Kaewpreedee, Lee, Peiris, Poon, Valkenburg) HKU-Pasteur Research Pole, School of Public Health, University of Hong Kong, Hong Kong Special Administrative Region, China | - |
dc.identifier.institution | (Cheng, Peiris, Poon) Division of Public Health Laboratory Sciences, School of Public Health, University of Hong Kong, Hong Kong Special Administrative Region, China | - |
dc.identifier.institution | (Kwok) Division of Transplantation and Immunogenetics, Department of Pathology, Queen Mary Hospital, Hong Kong Special Administrative Region, China | - |
dc.identifier.institution | (Jayasinghe, Gras) Infection & Immunity Program, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, VIC 3083, Australia | - |
dc.identifier.institution | (Jayasinghe, Gras) Department of Biochemistry and Chemistry, School of Agriculture, Biomedicine and Environment, La Trobe University, Bundoora, VIC 3083, Australia | - |
dc.identifier.institution | (Rossjohn) Institute of Infection and Immunity, Cardiff University School of Medicine, Cardiff CF14 4XN, United Kingdom | - |
dc.identifier.institution | (Cheng) School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC 3004, Australia | - |
dc.identifier.institution | (Cheng) Monash Infectious Diseases, Monash Health and School of Clinical Sciences, Monash University, Clayton, VIC 3168, Australia | - |
dc.identifier.institution | (Kotsimbos) Department of Respiratory Medicine, The Alfred Hospital, Melbourne, VIC 3004, Australia | - |
dc.identifier.institution | (Kotsimbos) Department of Medicine, Central Clinical School, The Alfred Hospital, Monash University, Melbourne, VIC 3004, Australia | - |
dc.identifier.institution | (Trubiano) Department of Infectious Diseases, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia | - |
dc.identifier.institution | (Trubiano) National Centre for Infections in Cancer, Peter McCallum Cancer Centre, Melbourne, VIC 3000, Australia | - |
dc.identifier.institution | (Trubiano) Department of Medicine (Austin Health), University of Melbourne, Heidelberg, VIC 3084, Australia | - |
dc.identifier.institution | (Trubiano, Holmes) Centre for Antibiotic Allergy and Research, Department of Infectious Diseases, Austin Health, Heidelberg, VIC 3084, Australia | - |
dc.identifier.institution | (Holmes) Department of Critical Care, University of Melbourne, Parkville, VIC 3000, Australia | - |
dc.identifier.institution | (Holmes) Data Analytics Research and Evaluation Centre, Austin Health and University of Melbourne, Heidelberg, VIC 3084, Australia | - |
dc.identifier.institution | (Pang Chan, Hui) Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong Special Administrative Region, China | - |
dc.identifier.institution | (Pang Chan, Hui) Li Ka Shing Institute of Health Sciences, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong Special Administrative Region, China | - |
dc.identifier.institution | (Peiris, Poon) Centre for Immunology and Infection, Hong Kong Science and Technology Park, Hong Kong Special Administrative Region, New Territories, China | - |
dc.identifier.institution | (Lewin, Thevarajan) Victorian Infectious Diseases Service, Royal Melbourne Hospital, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia | - |
dc.identifier.institution | (Lewin) Department of Infectious Disease, Alfred Hospital and Monash University, Melbourne, VIC 3000, Australia | - |
dc.identifier.affiliationmh | (Cheng) Monash Infectious Diseases, Monash Health and School of Clinical Sciences, Monash University, Clayton, VIC 3168, Australia | - |
item.openairetype | Article | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
crisitem.author.dept | Infectious Diseases and Clinical Microbiology | - |
crisitem.author.dept | Monash University - School of Public Health and Preventative Medicine | - |
Appears in Collections: | Articles |
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