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Title: | Epidemiology of childhood invasive pneumococcal disease in Australia: A prospective cohort study. | Authors: | Phuong L.K.;Cheung A.;Templeton T.;Abebe T.;Ademi Z.;Buttery J. ;Clark J.;Cole T.;Curtis N.;Dobinson H.;Shahul Hameed N.;Hernstadt H.;Ojaimi S. ;Sharp E.G.;Sinnaparajar P.;Wen S.;Daley A.;McMullan B.;Gwee A. | Monash Health Department(s): | Paediatric - General Paediatrics Pathology |
Institution: | (Phuong, Gwee) Murdoch Children's Research Institute, Parkville, VIC, Australia (Phuong, Buttery, Cole, Curtis, Daley, Gwee) Department of Paediatrics, University of Melbourne, Parkville, VIC, Australia (Cheung) Department of Allergy and Clinical Immunology, Women's and Children's Hospital, Adelaide, SA, Australia (Templeton, Clark, Wen) Infection Management Prevention Service, Queensland Children's Hospital, Brisbane, QLD, Australia (Abebe, Ademi) Health Economics and Policy Evaluation Research (HEPER), Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Melbourne, VIC, Australia (Ademi) School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia (Buttery, Curtis, Gwee) Infectious Diseases Unit, Department of General Medicine, Royal Children's Hospital, Parkville, VIC, Australia (Clark, Wen) University of Queensland, Brisbane, QLD, Australia (Cole) Department of Allergy and Immunology, Royal Children's Hospital, Melbourne, VIC, Australia (Cole) Murdoch Children's Research Institute, Parkville, VIC, Australia (Dobinson) Department of Paediatrics and Child Health, Te Whatu Ora Health New Zealand Capital, Coast and Hutt Valley, Lower Hutt, Wellington, New Zealand (Shahul Hameed) School of Medicine, Monash University, Clayton, VIC, Australia (Hernstadt) Department of Paediatrics, Monash Children's Hospital, Monash Health, Clayton, VIC, Australia (Ojaimi) Department of Paediatrics, Monash University, Clayton, VIC, Australia (Ojaimi) Monash Pathology, Monash Health, Clayton, VIC, Australia (Sharp, Sinnaparajar) Department of Immunology and Infectious Diseases, Sydney Children's Hospital, Sydney, NSW, Australia (Daley) Department of Microbiology, Royal Children's Hospital, Melbourne, VIC, Australia (McMullan) Sydney Children's Hospital Randwick, Randwick, NSW, Australia |
Issue Date: | 9-Oct-2024 | Copyright year: | 2024 | Publisher: | BMJ Publishing Group | Place of publication: | United Kingdom | Publication information: | Archives of Disease in Childhood. (no pagination), 2024. Article Number: archdischild-2024-327497. Date of Publication: 2024. | Journal: | Archives of Disease in Childhood | Abstract: | Background: The widespread use of pneumococcal conjugate vaccines (PCV) has changed the epidemiology of invasive pneumococcal disease (IPD) in children globally. Method(s): Multicentre prospective audit of IPD episodes from five paediatric hospitals in Australia over 5.5 years between 2016 and June 2021. Children (<18 years) with Streptococcus pneumoniae isolated from a sterile site were included. Result(s): There were 377 IPD episodes in 375 children: 338 (90%) had received >=3 PCV doses; 42 (11%) had IPD risk factors. The most common presentations were complicated pneumonia (254, 67%), bacteraemia (65, 17%) and meningitis (29, 8%). Five (1%) children died. Serotype information was available for 230 (61%) episodes; 140 (61%) were 13vPCV vaccine serotypes (VTs). The majority (85%) of episodes of complicated pneumonia were due to a VT; predominantly 3, 19A, 19F. Children with risk factors were more likely to present with bacteraemia +/- sepsis (42% vs 12%) and to have a non-vaccine serotype (NVT) (74% vs 32%). Resistance to ceftriaxone (meningitis cut-off) occurred in 17% of 23B isolates (n=12) and accounted for 22% (5/23) of meningitis cases. Conclusion(s): Complicated pneumonia is the most common IPD presentation. NVTs account for the majority of bacteraemia and meningitis episodes. High rates of ceftriaxone resistance for NVT 23B support the addition of vancomycin for empiric treatment of suspected meningitis.Copyright © Author(s) (or their employer(s)) 2024. | DOI: | http://monash.idm.oclc.org/login?url=https://dx.doi.org/10.1136/archdischild-2024-327497 | PubMed URL: | 39322267 [https://www.ncbi.nlm.nih.gov/pubmed/?term=39322267] | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/52558 | Type: | Article | Subjects: | bacteremia epidemiology infectious disease medicine meningitis pneumococcal infection pneumonia sepsis |
Type of Clinical Study or Trial: | Observational study (cohort, case-control, cross sectional, or survey) |
Appears in Collections: | Articles |
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