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Title: | Microbiology of catheter associated bloodstream infection: differences according to catheter type. | Authors: | MacPhail A.;Chraiti M.-N.;Zanella M.-C.;Hassoun-Kheir N.;Catho G.;Nguyen A.;Harbarth S.;Buetti N. | Monash Health Department(s): | Infectious Diseases and Clinical Microbiology | Institution: | (MacPhail) Infection Control Program and WHO Collaborating Centre, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland; Department of Infectious Diseases, Monash Health, Melbourne, Australia; School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia (Chraiti, Zanella, Hassoun-Kheir, Catho, Nguyen, Harbarth) Infection Control Program and WHO Collaborating Centre, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland (Buetti) Infection Control Program and WHO Collaborating Centre, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland; Infection Antimicrobials Modeling Evolution (IAME) U 1137, INSERM, Universite Paris-Cite, Paris, France |
Issue Date: | 4-Oct-2024 | Copyright year: | 2024 | Place of publication: | Canada | Publication information: | International Journal of Infectious Diseases. (pp 107247), 2024. Date of Publication: 27 Sep 2024. | Journal: | International Journal of Infectious Diseases | Abstract: | OBJECTIVES: Catheter-associated bloodstream infections (CABSI) cause preventable morbidity. We compared the microbiological aetiology of CABSI across different types of central and peripherally inserted catheters. METHOD(S): We analysed prospectively collected CABSI data in a 2100-bed hospital network in Switzerland between 2016 and 2022. We included: short-term non-tunnelled central venous catheters (CVC); long-term catheters (tunnelled, or peripherally inserted central catheters); arterial catheters; dialysis catheters; and peripheral venous catheters (PVC). We used multivariable logistic regression models to describe risk of Staphylococcus aureus and Gram-negative pathogens according to catheter type. RESULT(S): 416 CABSI episodes were included, including 60 episodes of S. aureus and 92 episodes of Gram-negative CABSI. Microbiological profile differed between catheter types. Together, PVC and dialysis catheters accounted for 43/60 (72%) of all S. aureus CABSI. After adjusting for age, sex and haematology/oncology care, odds of S. aureus were higher for haemodialysis catheters (OR 17.3, 95% CI 5.75-52.2, p <0.01) and PVC (OR 2.96, 95% CI 1.22-7.20, p=0.02) compared to short-term non-tunnelled CVC. Odds of Gram-negative organism as cause of CABSI were higher in long-term catheters versus short-term non-tunnelled CVC (OR 2.70, 95% CI 1.37-5.24). CONCLUSION(S): CABSI in catheters other than short-term non-tunnelled CVC are more commonly caused by virulent organisms including S. aureus and Gram-negative bacteria. Catheter type should be considered when selecting empirical antimicrobial therapies.Copyright © 2024. Published by Elsevier Ltd. | DOI: | http://monash.idm.oclc.org/login?url=https://dx.doi.org/10.1016/j.ijid.2024.107247 | PubMed URL: | 39343125 [https://www.ncbi.nlm.nih.gov/pubmed/?term=39343125] | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/52580 | Type: | Article | Subjects: | antimicrobial activity catheter related bloodstream infection hospital infection |
Type of Clinical Study or Trial: | Observational study (cohort, case-control, cross sectional, or survey) |
Appears in Collections: | Articles |
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