Please use this identifier to cite or link to this item: https://repository.monashhealth.org/monashhealthjspui/handle/1/52703
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dc.contributor.authorYang S.-
dc.contributor.authorKawasaki T.-
dc.contributor.authorKo B.-
dc.contributor.authorDe Bruyne B.-
dc.contributor.authorNorgaard B.-
dc.contributor.authorHwang D.-
dc.contributor.authorChun E.J.-
dc.contributor.authorNam C.-W.-
dc.contributor.authorMatsuo H.-
dc.contributor.authorKubo T.-
dc.contributor.authorLeipsic J.-
dc.contributor.authorShaw L.-
dc.contributor.authorNarula J.-
dc.contributor.authorKoo B.-K.-
dc.date.accessioned2024-11-22T03:37:27Z-
dc.date.available2024-11-22T03:37:27Z-
dc.date.copyright2024-
dc.date.issued2024-10-23en
dc.identifier.citationJournal of the American College of Cardiology. Conference: Thirty-Sixth Annual Symposium Transcatheter Cardiovascular Therapeutics (TCT). Walter E. Washington Convention Center, Washington United States. 84(18 Supplement) (pp B90), 2024. Date of Publication: 29 Oct 2024.-
dc.identifier.urihttps://repository.monashhealth.org/monashhealthjspui/handle/1/52703-
dc.description.abstractBackground: The comparative effectiveness between anatomy- and physiology-based acute coronary syndrome (ACS) risk assessment has not been fully defined. Method(s): This international, multicenter, internal case-control study enrolled 351 patients undergoing coronary computed tomography angiography (CCTA) and experiencing ACS between 1 month and 3 years later after medical follow-up. The lesions on CCTA were adjudicated to culprit and nonculprit lesions according to the invasive coronary angiography at the ACS event. Core laboratory CCTA analyses revealed 4 lesion-specific anatomical and physiological characteristics: the degree of stenosis, the number of adverse plaque characteristics, plaque burden at minimum lumen area, and changes in CCTA-derived fractional flow reserve across the lesion (DELTAFFRCT). Result(s): Among the total of 2,451 lesions defined on CCTA, 363 lesions (14.8%) became the culprit of ACS with a median interval of 375 days. Four anatomical and physiological lesion characteristics showed a direct association with ACS culprit risk, not mediated by other characteristics (all P < 0.001). In identifying ACS culprit lesions, plaque burden >=70% showed the highest sensitivity of 90.6% (87.2%-93.2%), and DELTAFFRCT >=0.10 had the highest specificity of 88.3% (86.9%-89.6%). The predictability was similar between DELTAFFRCT and the combined other anatomical characteristics (AUC: 0.805 vs 0.802; P = 0.778), with additive discrimination toward each other (Figure). [Formula presented] Conclusion(s): Luminal narrowing, plaque quality and quantity, and local hemodynamics were independent predictors of ACS, offering specificity in physiology and sensitivity in anatomy. Categories: IMAGING AND PHYSIOLOGY: Physiologic Lesion Assessment.Copyright © 2024-
dc.publisherElsevier Inc.-
dc.relation.ispartofJournal of the American College of Cardiology-
dc.subject.meshacute coronary syndrome-
dc.subject.meshcomputed tomographic angiography-
dc.subject.meshcoronary angiography-
dc.subject.meshhemodynamics-
dc.titleTCT-349 Anatomical versus physiological lesion characteristics in prediction of acute coronary syndrome.-
dc.typeConference Abstract-
dc.identifier.affiliationCardiology (MonashHeart)-
dc.description.conferencenameThirty-Sixth Annual Symposium Transcatheter Cardiovascular Therapeutics (TCT)-
dc.description.conferencelocationWalter E. Washington Convention Center, Washington, United States-
dc.identifier.doihttps://dx.doi.org/10.1016/j.jacc.2024.09.403-
local.date.conferencestart2024-10-27-
dc.identifier.institution(Yang, Hwang, Koo) Seoul National University Hospital, Seoul, South Korea-
dc.identifier.institution(Kawasaki) Shin-Koga Hospital, Kurume, Japan, Japan-
dc.identifier.institution(Ko) Victorian Heart Hospital, Melbourne, Victoria, Australia, Australia-
dc.identifier.institution(De Bruyne) Cardiovascular Center Aalst, Aalst, Belgium, Belgium-
dc.identifier.institution(Norgaard) Aarhus University Hospital, Aarhus University, Aarhus, Denmark, Denmark-
dc.identifier.institution(Chun) Seoul National University Bundang Hospital, Gyeong-gi, South Korea-
dc.identifier.institution(Nam) Keimyung University Dongsan Hospital, Daegu, South Korea-
dc.identifier.institution(Matsuo) Gifu Heart Center, Gifu, Japan, Japan-
dc.identifier.institution(Kubo) Tokyo Medical University Hachioji Medical Center, Tokyo, Japan, Japan-
dc.identifier.institution(Leipsic) St. Paul's Hospital, Vancouver, British Columbia, Canada, Canada-
dc.identifier.institution(Shaw) Mt Sinai Hospital, New York, New York, USA, United States-
dc.identifier.institution(Narula) Mount Sinai Hospital Morningside, New York, New York, USA, United States-
local.date.conferenceend2024-10-30-
dc.identifier.affiliationmh(Ko) Victorian Heart Hospital, Melbourne, Victoria, Australia, Australia-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.openairetypeConference Abstract-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
crisitem.author.deptCardiology (MonashHeart & Victorian Heart Institute)-
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