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Conference/Presentation Title: | A roadmap for research in post-stroke fatigue: consensus-based core recommendations from the third stroke recovery and rehabilitation roundtable. | Authors: | English C.;Simpson D.;Billinger S.;Churilov L.;Coupland K.;Drummond A.;Kuppaswamy A.;Kutlubaev M.;Lerdal A.;Mahmood A.;Moseley L.;Pittman Q.;Riley E.;Sutherland B.;Wong C.;Corbett D.;Mead G. | Monash Health Department(s): | Centre for Inflammatory Diseases at Monash Health Monash University - School of Clinical Sciences at Monash Health |
Institution: | (English, Simpson, Coupland) Univ of Newcastle, Wickham, NSW, Australia (Billinger) Department of Neurology, Univ of Kansas Medical Centre, Univ of Kansas Alzheimer's Disease Research Centre, Kansas, United States (Churilov) Department of Medicine (RMH), Univ of Melbourne, Melbourne, VIC, Australia (Drummond) School of Health Sciences, Univ of Nottingham, Nottingham, United Kingdom (Kuppaswamy) School of Biomedical Sciences, Univ of Leeds, Leeds, United Kingdom (Kutlubaev) Department of Neurology, Bashkir State Medical Univ, Ufa, Russian Federation (Lerdal) Department of Interdisciplinary Health Sciences, Institute of Health and Society, Faculty of Medicine, Univ of Oslo, Oslo, Norway (Mahmood) Faculty of Health, Psychology and Social Care, Manchester Metropolitan Univ, Manchester, United Kingdom (Moseley) IIMPACT in Health, Univ of South Australia, Adelaide, SA, Australia (Pittman) Department of Physiology and Pharmacology, Hotchkiss Brain Institute, Univ of Calgary, Calgary, AB, Canada (Riley) Department of Communication Sciences and Disorders, Syracuse Univ, Syracuse, NY, United States (Sutherland) Tasmanian School of Medicine, College of Health and Medicine, Univ of Tasmania, Hobart, TAS, Australia (Wong) Centre for Inflammatory Diseases, Department of Medicine School of Clinical Sciences at Monash Health, Monash Univ, Melbourne, VIC, Australia (Corbett) Dept Cellular and Molecular Medicine, Roger Guindon Hall, Univ of Ottawa, ON, Canada (Mead) Ageing and Health, Usher Institute, Univ of Edinburgh, Edinburgh, United Kingdom |
Presentation/Conference Date: | 13-Nov-2024 | Copyright year: | 2024 | Publication information: | Cerebrovascular Diseases. Conference: Asia Pacific Stroke Conference 2024 Combined Australian and New Zealand Stroke Organisation Transcending Borders. Adelaide, SA Australia. 53(Supplement 1) (pp 14), 2024. Date of Publication: 2024. | Journal: | Cerebrovascular Diseases | Abstract: | Background/Aims: Fatigue affects almost half of all people living with stroke. Stroke survivors rank understanding fatigue and how to reduce it as one of the highest research priorities. The Stroke Recovery and Rehabilitation Roundtables (SRRR) bring together leading international experts and deliver consensus recommendations for stroke rehabilitation and recovery research, and are endorsed by the World Stroke Organisation. Method(s): Following the methodology of the SRRRs, we convened an interdisciplinary, international group of clinical and pre-clinical researchers and lived experience experts. We focused on four priority areas: (1) best measurement tools for post-stroke fatigue research, (2) clinical identification of post-stroke fatigue and potentially modifiable causes, (3) promising interventions and recommendations for future trials and (4) possible biological mechanisms of post-stroke fatigue. Result(s): We developed and published 20 recommendations. These include recommendations for outcome measures for future trials, and how to interpret results of past trials based on the measures used. We developed the Stroke Fatigue Clinical Assessment Tool for identifying potential modifiable contributors to post-stroke fatigue. The most promising interventions that warrant further research include psychoeducational interventions, exercise, dopamine re-uptake inhibitors and neuromodulation therapies. The potential biological mechanisms of fatigue are likely multifactorial and could include systemic inflammation, gut dysbiosis, genetics, post-stroke alteration of cellular energy stores and/or dysfunction in sensorimotor processing. Our work1 is already highly influential (>2,700 downloads, altmetric score 138 and field-weighted citation impact = 29). Conclusion(s): By synthesising current knowledge in post-stroke fatigue across clinical and pre-clinical fields, our work provides a roadmap for future research. | Conference Name: | Asia Pacific Stroke Conference 2024 Combined Australian and New Zealand Stroke Organisation Transcending Borders | Conference Start Date: | 2024-09-25 | Conference End Date: | 2024-09-28 | Conference Location: | Adelaide, SA, Australia | DOI: | http://monash.idm.oclc.org/login?url=https://dx.doi.org/10.1159/000541320 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/52775 | Type: | Conference Abstract | Subjects: | cerebrovascular accident dysbiosis neuromodulation rehabilitation stroke rehabilitation stroke survivor |
Type of Clinical Study or Trial: | Review article (e.g. literature review, narrative review) |
Appears in Collections: | Conferences |
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