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https://repository.monashhealth.org/monashhealthjspui/handle/1/58053| Title: | Atypical femoral fracture with early PET/CT changes from denosumab for metastatic breast cancer and transition from denosumab to zoledronic acid. | Authors: | Tan C.;Ebeling P.R. ;White M. ;Milat F.;Nguyen H.H.;Man G.;Day D. | Monash Health Department(s): | Monash University - School of Clinical Sciences at Monash Health Oncology Endocrinology |
Institution: | (Man, Nguyen, Ebeling, Milat) Department of Endocrinology, Monash Health, Melbourne, Australia (Tan, Milat) Hudson Institute of Medical Research, Melbourne, Australia (Tan, Day, White, Nguyen, Ebeling, Milat) Department of Medicine, School of Clinical Sciences, Monash University, Melbourne, Australia (Day, White) Department of Oncology, Monash Health, Melbourne, Australia |
Issue Date: | 8-Apr-2026 | Copyright year: | 2026 | Publisher: | Elsevier Inc. | Place of publication: | United States | Publication information: | Bone. 206(no pagination), 2026. Article Number: 117821. Date of Publication: 01 May 2026. | Journal: | Bone | Abstract: | Atypical femoral fractures (AFFs) are potential complications arising from long-term use of bone modifying agents such as denosumab. We describe a case of bilateral AFFs that was treated surgically in a middle-aged woman receiving oncologic doses of denosumab for treatment of metastatic breast cancer for seven years. In retrospect, early cortical change was present on scout computer tomography (CT) and positron emission tomography-computer tomography (PET-CT) prior to her left AFF. This case highlights the potential for earlier opportunistic AFF radiologic screening during cancer surveillance. It also describes our experience with preserving spinal bone density following the cessation of oncologic doses of denosumab through sequential zoledronic acid therapy.Copyright © 2026 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license. http://creativecommons.org/licenses/by/4.0/ | DOI: | https://dx.doi.org/10.1016/j.bone.2026.117821 | PubMed URL: | 41654156 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/58053 | Type: | Article |
| Appears in Collections: | Articles |
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