Please use this identifier to cite or link to this item:
https://repository.monashhealth.org/monashhealthjspui/handle/1/26828
Title: | Hypertension guidelines, meta-analyses and clinical trials: Do we assume too much?. | Authors: | Peverill R.E. | Institution: | (Peverill) Centre for Heart and Chest Research, Monash University Dept. of Medicine, Monash Medical Centre, 246 Clayton Road, Clayton, Vic. 3168, Australia | Issue Date: | 17-Oct-2012 | Copyright year: | 2005 | Publisher: | Australasian Medical Publishing Co. Ltd Australasian Medical Publishing Co. Ltd (Level 2, 26-32 Pyrmont Bridge Road, Pyrmont NSW 2009, Australia) |
Place of publication: | Australia | Publication information: | Medical Journal of Australia. 182 (2) (pp 82-84), 2005. Date of Publication: 17 Jan 2005. | Journal: | Medical Journal of Australia | Abstract: | * Given fundamental differences in the recommendations in guidelines from major national and international committees, we cannot rely on them unquestioningly. * Different antihypertensive agents are known to have differing effects according to age and race. * Exchanging (rather than following guideline recommendations of adding to) an ineffective first-line antihypertensive drug can result in control of hypertension with monotherapy. * Conclusions about a preferable first-line antihypertensive agent are limited by trial protocols with varying drug doses and questionable drug combinations. * Guidelines are often based on meta-analyses of drugs of a particular class, which could ignore important differences between drugs within a class. * Trials of 3-5 years cannot determine the long-term effects of drugs which patients often take for decades. | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.5694/j.1326-5377.2005.tb06582.x | PubMed URL: | 15651968 [http://www.ncbi.nlm.nih.gov/pubmed/?term=15651968] | ISSN: | 0025-729X | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/26828 | Type: | Review | Subjects: | monotherapy patient care practice guideline race review treatment planning *antihypertensive agent/ae [Adverse Drug Reaction] *antihypertensive agent/ct [Clinical Trial] *antihypertensive agent/cm [Drug Comparison] *antihypertensive agent/dt [Drug Therapy] beta adrenergic receptor blocking agent/dt [Drug Therapy] calcium channel blocking agent/dt [Drug Therapy] chlortalidone/ct [Clinical Trial] chlortalidone/cm [Drug Comparison] chlortalidone/dt [Drug Therapy] dipeptidyl carboxypeptidase inhibitor/ct [Clinical Trial] dipeptidyl carboxypeptidase inhibitor/cm [Drug Comparison] dipeptidyl carboxypeptidase inhibitor/dt [Drug Therapy] diuretic agent/ct [Clinical Trial] diuretic agent/cm [Drug Comparison] diuretic agent/dt [Drug Therapy] lisinopril/ct [Clinical Trial] lisinopril/cm [Drug Comparison] lisinopril/dt [Drug Therapy] perindopril/ct [Clinical Trial] perindopril/cm [Drug Comparison] perindopril/dt [Drug Therapy] placebo ramipril/ct [Clinical Trial] ramipril/cm [Drug Comparison] ramipril/dt [Drug Therapy] thiazide diuretic agent/ae [Adverse Drug Reaction] thiazide diuretic agent/dt [Drug Therapy] *hypertension/dt [Drug Therapy] age cardiovascular disease/dt [Drug Therapy] cardiovascular disease/pc [Prevention] cardiovascular disease/si [Side Effect] clinical protocol clinical trial comparative study diabetes mellitus/si [Side Effect] disease control drug classification drug efficacy health care organization human long term care meta analysis monotherapy patient care practice guideline review treatment planning comparative study clinical trial clinical protocol cardiovascular disease / drug therapy / prevention / side effect age race disease control drug classification drug efficacy health care organization human *hypertension / *drug therapy long term care meta analysis diabetes mellitus / side effect |
Type of Clinical Study or Trial: | Systematic review and/or meta-analysis |
Appears in Collections: | Articles |
Show full item record
Items in Monash Health Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.