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Title: | Hypertension guidelines, meta-analyses and clinical trials: Do we assume too much?. | Authors: | Peverill R.E. | Institution: | (Peverill) Centre for Heart and Chest Research, Monash University Dept. of Medicine, Monash Medical Centre, 246 Clayton Road, Clayton, Vic. 3168, Australia | Issue Date: | 17-Oct-2012 | Copyright year: | 2005 | Publisher: | Australasian Medical Publishing Co. Ltd Australasian Medical Publishing Co. Ltd (Level 2, 26-32 Pyrmont Bridge Road, Pyrmont NSW 2009, Australia) |
Place of publication: | Australia | Publication information: | Medical Journal of Australia. 182 (2) (pp 82-84), 2005. Date of Publication: 17 Jan 2005. | Journal: | Medical Journal of Australia | Abstract: | * Given fundamental differences in the recommendations in guidelines from major national and international committees, we cannot rely on them unquestioningly. * Different antihypertensive agents are known to have differing effects according to age and race. * Exchanging (rather than following guideline recommendations of adding to) an ineffective first-line antihypertensive drug can result in control of hypertension with monotherapy. * Conclusions about a preferable first-line antihypertensive agent are limited by trial protocols with varying drug doses and questionable drug combinations. * Guidelines are often based on meta-analyses of drugs of a particular class, which could ignore important differences between drugs within a class. * Trials of 3-5 years cannot determine the long-term effects of drugs which patients often take for decades. | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.5694/j.1326-5377.2005.tb06582.x | PubMed URL: | 15651968 [http://www.ncbi.nlm.nih.gov/pubmed/?term=15651968] | ISSN: | 0025-729X | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/26828 | Type: | Review | Type of Clinical Study or Trial: | Systematic review and/or meta-analysis |
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