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https://repository.monashhealth.org/monashhealthjspui/handle/1/26932| Chapter/Book title: | A Method for the Establishment of Human Lung Adenocarcinoma Patient-Derived Xenografts in Mice. | Authors: | Jenkins B.J.;Lundy J.;Saad M.I. | Institution: | (Lundy, Jenkins, Saad) Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC, Australia (Lundy, Jenkins, Saad) Department of Molecular and Translational Sciences, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, VIC, Australia (Lundy) Department of Surgery, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia | Publication year: | 2021 | Publisher: | Humana Press Inc. | Place of publication: | United States | Publication information: | Methods in Molecular Biology. 2279 (pp 165-173), 2021. Date of Publication: 2021. | Book title: | Methods in Molecular Biology | Abstract: | Patient-derived xenografts (PDXs) are created by implanting human tumor tissue or cells into immunodeficent mice, and enable the study of tumor biology, biomarkers and response to therapy in vivo. This chapter describes a method for lung adenocarcinoma (LAC) PDX generation using subcutaneous implantation of tumor tissue and cell suspensions and incorporating the humanization of PDX models by reconstitution with human immune cells.Copyright © 2021, Springer Science+Business Media, LLC, part of Springer Nature. | DOI: | http://monash.idm.oclc.org/login?url= http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1007/978-1-0716-1278-1_13 |
PubMed URL: | 33683693 [http://www.ncbi.nlm.nih.gov/pubmed/?term=33683693] | ISSN: | 1064-3745 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/26932 | Type: | Chapter Chapter |
| Appears in Collections: | Books and Book Chapters |
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