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https://repository.monashhealth.org/monashhealthjspui/handle/1/26975| Title: | Pregnancy outcomes for simultaneous Pancreas-Kidney transplant recipients versus kidney transplant recipients. | Authors: | Jesudason S.;Tang J.;Gulyani A.;Hewawasam E.;McDonald S.;Clayton P.;Webster A.C.;Kanellis J. | Monash Health Department(s): | Nephrology | Institution: | (Tang, McDonald, Clayton, Jesudason) Central and Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital, Adelaide, SA, Australia (Gulyani, Hewawasam, McDonald, Clayton, Jesudason) Australia and New Zealand Dialysis and Transplant Registry (ANZDATA) and Australian and New Zealand Organ Donation Registry (ANZOD), South Australian Health & Medical Research Institute (SAHMRI), Adelaide, SA, Australia (Hewawasam, McDonald, Clayton) Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, SA, Australia (Webster) School of Public Health, The University of Sydney, Sydney, NSW, Australia (Webster) Centre for Transplant and Renal Research, Westmead Hospital, Westmead, NSW, Australia (Kanellis) Department of Nephrology, Monash Health and Centre for Inflammatory Diseases, Clayton, VIC, Australia (Kanellis) Department of Medicine, Monash University, Clayton, VIC, Australia | Issue Date: | 16-Mar-2021 | Copyright year: | 2021 | Publisher: | Blackwell Publishing Ltd | Place of publication: | United Kingdom | Publication information: | Clinical Transplantation. 35 (1) (no pagination), 2021. Article Number: e14151. Date of Publication: January 2021. | Journal: | Clinical Transplantation | Abstract: | Data about pregnancy outcomes for simultaneous pancreas-kidney transplant recipients (SPKR) are limited. We compared pregnancy outcomes in SPKR to Kidney Transplant Recipients (KTR) from 2001-17 using the Australia and New Zealand Dialysis and Transplant (ANZDATA) Registry and the Australian and New Zealand Pancreas Islet Transplant Registry (ANZPITR). A total of 19 pregnancies to 15 SPKR mothers, and 348 pregnancies to 235 KTR mothers were reported. Maternal ages were similar (SPKR 33.9 +/- 3.9 years; KTR 32.1 +/- 4.8 years, p =.10); however, SPKR had a shorter transplant to first-pregnancy interval compared to KTR (SPKR 3.3 years, IQR (1.7, 4.1); KTR 5 years, IQR (2.6, 8.7), p =.02). Median difference in creatinine pre- and post-pregnancy was similar between the groups (KTR -3 micromol/L, IQR (-15, 6), SPKR -3 micromol/L, IQR (-11, 3), p =.86). Maternal, fetal and kidney transplant outcomes were similar despite higher rates of pre-existing peripheral vascular and coronary artery diseases in SPKR. Live birth rates (>20 weeks) were comparable (SPKR 93.8% vs. KTR 96.8%, p =.06). KTR with either type 1 or type 2 diabetes mellitus (24 births) had similar outcomes compared to SPKR. In this national cohort, pregnancy outcomes were similar between SPKR and KTR mothers; however, findings should be interpreted with caution due to small sample sizes.Copyright © 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd | DOI: | http://monash.idm.oclc.org/login?url= http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1111/ctr.14151 |
PubMed URL: | 33179349 [http://www.ncbi.nlm.nih.gov/pubmed/?term=33179349] | ISSN: | 0902-0063 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/26975 | Type: | Article | Subjects: | *kidney pancreas transplantation live birth major clinical study maternal age non insulin dependent diabetes mellitus pancreas function peripheral vascular disease *pregnancy outcome pregnant woman primigravida priority journal creatinine/ec [Endogenous Compound] cyclosporine/dt [Drug Therapy] mycophenolate mofetil/dt [Drug Therapy] mycophenolic acid/dt [Drug Therapy] tacrolimus/dt [Drug Therapy] mammalian target of rapamycin inhibitor/dt [Drug Therapy] adult article Australia and New Zealand clinical decision making cohort analysis comparative study controlled study coronary artery disease creatinine blood level disease registry *end stage renal disease/dt [Drug Therapy] *end stage renal disease/su [Surgery] female fetus outcome *graft recipient human immunosuppressive treatment insulin dependent diabetes mellitus kidney function *kidney graft *graft recipient human comparative study cohort analysis insulin dependent diabetes mellitus kidney function *kidney graft *kidney pancreas transplantation live birth major clinical study maternal age non insulin dependent diabetes mellitus pancreas function peripheral vascular disease *pregnancy outcome pregnant woman primigravida priority journal clinical decision making Australia and New Zealand Article adult immunosuppressive treatment controlled study coronary artery disease creatinine blood level disease registry *end stage renal disease / *drug therapy / *surgery female fetus outcome |
Type of Clinical Study or Trial: | Observational study (cohort, case-control, cross sectional or survey) |
| Appears in Collections: | Articles |
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