Please use this identifier to cite or link to this item: https://repository.monashhealth.org/monashhealthjspui/handle/1/27037
Title: Prevalence and Age of Onset of Regression in Children with Autism Spectrum Disorder: A Systematic Review and Meta-analytical Update.
Authors: Williams K.;Ure A.;Tan C.;Frewer V.;Cox G.
Institution: (Tan, Frewer, Williams, Ure) Department of Paediatrics and Melbourne School of Medicine, University of Melbourne, Melbourne, VIC, Australia (Frewer, Cox, Williams, Ure) Neurodisability & Rehabilitation, Murdoch Children's Research Institute, Parkville, VIC, Australia (Cox, Williams, Ure) Department of Paediatrics & Education Research, Monash University, Clayton, VIC, Australia (Williams, Ure) Developmental Paediatrics, Monash Children's Hospital, Clayton, VIC, Australia
Issue Date: 11-Mar-2021
Copyright year: 2021
Publisher: John Wiley and Sons Inc
Place of publication: United States
Publication information: Autism Research. 14 (3) (pp 582-598), 2021. Date of Publication: March 2021.
Journal: Autism Research
Abstract: Abstract: A systematic review published in 2013 reported 32% of children on the autism spectrum experience skill loss, known as autistic regression. However, the frequency varied depending on definition and measures used to capture skills. Retrospective parent report and prospective observation indicate loss of language and/or social skills, with motor skills typically unaffected. Our aim was to update the prevalence and age of onset of autistic regression through a meta-analysis of the literature to understand if there have been changes to the reported onset and prevalence since 2010. A systematic literature search was conducted using Medline, Embase, PsycINFO, and the Cochrane Library databases and included studies published from 2010 onward. Risk of bias assessment was performed on included studies. A random effects model was used to calculate the pooled prevalence and age of onset of autistic regression. Ninety-seven studies were included in the systematic review, of which 75 studies involving 33,014 participants had sufficient data for meta-analytic syntheses. The pooled proportion of autistic regression was 30% (95% confidence interval [CI]: 27-32%) but heterogeneity was high (I2 = 96.91) and did not reduce with sensitivity or subgroup analyses based on study design or clinical differences, respectively. Prevalence varied according to risk of bias (low: 27%) and definition of regression (language: 20%, language/social: 40%, mixed: 30%, and unspecified: 27%). Weighted average age of onset was 19.8 months. Findings from this meta-analysis highlight the importance of developing a standardized definition of autistic regression, and tools to measure this at multiple time points during early childhood development. Lay summary: About a third of children with Autism Spectrum Disorder experience loss of skills, which is also known as autistic regression. This paper provides an update of the rate of autistic regression in children and the age when they first experience loss of skills, based on current studies. The findings from this review contribute to our understanding of the onset patterns of autistic regression. Unfortunately, studies are not sufficiently similar, making it difficult to provide clear answers on the exact timing or type of regression seen in different children.Copyright © 2021 International Society for Autism Research, Wiley Periodicals LLC.
DOI: http://monash.idm.oclc.org/login?url=
http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1002/aur.2463
PubMed URL: 33491292 [http://www.ncbi.nlm.nih.gov/pubmed/?term=33491292]
ISSN: 1939-3792
URI: https://repository.monashhealth.org/monashhealthjspui/handle/1/27037
Type: Article
Subjects: intervention study
article
*autism/ep [Epidemiology]
child
child development
comprehension
confidence interval
genetic heterogeneity
human
language
meta analysis
*onset age
outcome assessment
*prevalence
priority journal
*remission
risk assessment
sensitivity analysis
skill
social behavior
study design
systematic review
human
intervention study
language
meta analysis
*onset age
outcome assessment
*prevalence
priority journal
*remission
risk assessment
study design
skill
sensitivity analysis
Article
*autism / *epidemiology
child
child development
comprehension
confidence interval
genetic heterogeneity
systematic review
social behavior
Type of Clinical Study or Trial: Systematic review and/or meta-analysis
Appears in Collections:Articles

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