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Title: | Predictive Value of Quick Sepsis-Related Organ Failure Scores following Sepsis-Related Medical Emergency Team Calls: A Retrospective Cohort Study. | Authors: | Giang V.;Choy A.;Nguyen J.;Le S. ;Hall T.;Boulos D.;Shehabi Y. ;Moghaddas J.A.;Birrell M. | Monash Health Department(s): | General Medicine | Institution: | (Boulos) Department of General Medicine, Monash Health, Clinical Informatics, Monash Health, Melbourne, VIC, Australia (Shehabi) Critical Care Medicine, Monash Health, Melbourne, VIC, Australia (Moghaddas) Department of General Medicine, Monash Health, Melbourne, VIC, Australia (Birrell) Department of Infectious Diseases, Monash Health, Melbourne, VIC, Australia (Choy, Giang) Medicine, Monash University, Melbourne, VIC, Australia (Nguyen, Hall) School of Clinical Sciences, Monash University, Melbourne, VIC, Australia (Le) EMR Clinical Benefits Clinician, Clinical Informatics, Monash Health, Melbourne, VIC, Australia | Issue Date: | 25-Feb-2021 | Copyright year: | 2017 | Publisher: | SAGE Publications Inc. | Place of publication: | Australia | Publication information: | Anaesthesia and Intensive Care. 45 (6) (pp 688-694), 2017. Date of Publication: November 2017. | Journal: | Anaesthesia and Intensive Care | Abstract: | We conducted a cohort study of adult ward patients who had a Medical Emergency Team (MET) call triggered by confirmed or suspected sepsis in an Australian tertiary centre to assess the predictive utility of systemic inflammatory response syndrome (SIRS) and quick Sepsis-Related Organ Failure Assessment (qSOFA) scores for 28-day mortality over a 12-month period. Sepsis was the causative aetiology in 970 MET calls for 646 patients with a mean age of 68 years and median Charlson Comorbidity score (CCS) of 3.0. Four hundred and seven (63%) patients had microbiological identification of a causative organism with 35 (9%) demonstrating multi-drug resistance. The 28-day mortality rate was 22%. Independent risk factors for 28-day mortality included age (incidence rate ratio [IRR] 1.038; P <0.001) and CCS (IRR 1.102; P <0.001). qSOFA positive patients had a threefold risk of 28-day mortality compared to those who were negative (IRR 3.15; P=0.02). Both the SIRS and qSOFA score had poor sensitivity (86% versus 62%, respectively) for mortality as a sole diagnostic tool and should be investigated as part of a multiparameter panel within a large prospective study.Copyright © 2017 Australian Society of Anaesthetists. | DOI: | http://monash.idm.oclc.org/login?url= http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1177/0310057X1704500607 |
PubMed URL: | 29137578 [http://www.ncbi.nlm.nih.gov/pubmed/?term=29137578] | ISSN: | 0310-057X | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/27220 | Type: | Article | Subjects: | Charlson Comorbidity Index *cohort analysis controlled study diagnostic test accuracy study female human incidence major clinical study male *mortality rate multidrug resistance *organ dysfunction score prospective study *rapid response team *retrospective study *risk assessment risk factor *sepsis Sequential Organ Failure Assessment Score *predictive value adult aged article *mortality rate [m] multidrug resistance [m] *organ dysfunction score [m] *predictive value [m] prospective study [m] *rapid response team [m] *retrospective study [m] *risk assessment [m] risk factor [m] *sepsis [m] Sequential Organ Failure Assessment Score [m] incidence [m] human [m] female [m] diagnostic test accuracy study [m] controlled study [m] major clinical study [m] male [m] *cohort analysis [m] Charlson Comorbidity Index [m] article [m] aged [m] adult [m] |
Type of Clinical Study or Trial: | Observational study (cohort, case-control, cross sectional or survey) |
Appears in Collections: | Articles |
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