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https://repository.monashhealth.org/monashhealthjspui/handle/1/27642| Title: | Overcoming technical challenges when treating atypical hemolytic uremic syndrome with therapeutic plasma exchange. | Authors: | Zimbudzi E. | Institution: | (Zimbudzi) Department of Nephrology, Monash Health, Monash Medical Centre, VIC, Australia | Issue Date: | 19-Dec-2013 | Copyright year: | 2013 | Publisher: | Dove Medical Press Ltd (PO Box 300-008, Albany, 44 Corinthian Drive, Albany,Auckland 0752, New Zealand) | Place of publication: | New Zealand | Publication information: | International Journal of Nephrology and Renovascular Disease. 6 (pp 245-248), 2013. Date of Publication: 19 Nov 2013. | Abstract: | Atypical hemolytic uremic syndrome (aHUS) is a very rare, life-threatening, progressive disease that frequently has a genetic component and in most cases is triggered by an uncontrolled activation of the complement system. Successful treatment of aHUS with plasma infusions and therapeutic plasma exchange (TPE) is well reported. TPE has been the treatment of choice in most adult patients with aHUS. However, due to severe hemolysis, which is common among aHUS patients, there are some technical challenges that can affect TPE treatment such as the continuous activation of the blood leak alarm due to hemolysis. Our experience shows that such patients can be managed better on a centrifuge based TPE machine compared to a membrane based TPE machine. © 2013 Zimbudzi. | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.2147/IJNRD.S53074 | ISSN: | 1178-7058 (electronic) | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/27642 | Type: | Article | Subjects: | fever flow rate follow up glomerulus filtration rate hematocrit hemolytic uremic syndrome/dt [Drug Therapy] *hemolytic uremic syndrome/dt [Drug Therapy] *hemolytic uremic syndrome/th [Therapy] hospital discharge human human cell kidney dysfunction lactate dehydrogenase blood level lipoprotein blood level medical device medical device complication/co [Complication] normochromic normocytic anemia/di [Diagnosis] *plasmapheresis potassium blood level protein blood level relapse remission sore throat thrombocyte count thrombocytopenia/di [Diagnosis] thrombotic thrombocytopenic purpura/di [Diagnosis] urea blood level urine color vital sign C reactive protein/ec [Endogenous Compound] creatinine/ec [Endogenous Compound] eculizumab/dt [Drug Therapy] haptoglobin/ec [Endogenous Compound] hemoglobin/ec [Endogenous Compound] lactate dehydrogenase/ec [Endogenous Compound] low density lipoprotein/ec [Endogenous Compound] potassium/ec [Endogenous Compound] urea/ec [Endogenous Compound] blood leak alarm/co [Complication] centrifuge based therapeutic plasma exchange machine membrane based therapeutic plasma exchange machine hemolysis adult arteriovenous fistula article biochemistry blood examination blood vessel catheterization case report creatinine blood level drug bioavailability erythrocyte erythrocyte count female drug bioavailability erythrocyte erythrocyte count female fever flow rate follow up glomerulus filtration rate hematocrit hemolysis hemolytic uremic syndrome / drug therapy *hemolytic uremic syndrome / *drug therapy / *therapy hospital discharge human human cell kidney dysfunction lactate dehydrogenase blood level lipoprotein blood level medical device medical device complication / complication normochromic normocytic anemia / diagnosis *plasmapheresis potassium blood level protein blood level relapse adult sore throat thrombocyte count thrombocytopenia / diagnosis thrombotic thrombocytopenic purpura / diagnosis urea blood level urine color vital sign remission arteriovenous fistula article biochemistry blood examination blood vessel catheterization case report creatinine blood level |
Type of Clinical Study or Trial: | Case series or case report |
| Appears in Collections: | Articles |
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