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Title: | Mending a growth-restricted fetal heart: Should we use glucocorticoids. | Authors: | Hodges R.J.;Wallace E.M. | Monash Health Department(s): | Obstetrics and Gynaecology (Monash Women's) | Institution: | (Hodges, Wallace) Maternal Fetal Medicine, Monash Medical Centre, Southern Health, VIC, Australia (Hodges, Wallace) Department of Obstetrics and Gynaecology, Southern Clinical School, Monash University, 246 Clayton Road, VIC, 3168, Australia | Issue Date: | 7-Nov-2012 | Copyright year: | 2012 | Publisher: | Informa Healthcare (69-77 Paul Street, London EC2A 4LQ, United Kingdom) | Place of publication: | United Kingdom | Publication information: | Journal of Maternal-Fetal and Neonatal Medicine. 25 (11) (pp 2149-2153), 2012. Date of Publication: November 2012. | Abstract: | Clinical and experimental studies suggest that the growth-restricted fetus at increased risk of impaired cardiovascular function that likely contributes to both increased mortality rate and in survivors, to cardiovascular dysfunction apparent in childhood and later life. Fetal growth restriction is also associated with a high risk of preterm birth. Accordingly, the growth-restricted fetus is more likely than average to receive antenatal glucocorticoids to accelerate lung maturation in preparation for birth. However, glucocorticoids are powerful regulators of vascular tone and antenatal glucocorticoid administration to the intrauterine growth restriction (IUGR) fetus results in systemic cardiovascular changes that are not observed in the healthy normal grown fetus. These responses to glucocorticoids may disturb the IUGR fetus' ability to appropriately compensate to placental insufficiency. Indeed is it possible that in the setting of severe IUGR exogenous glucocorticoids are detrimental rather than beneficial to the fetus © 2012 Informa UK, Ltd. | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.3109/14767058.2012.697940 | PubMed URL: | 22764774 [http://www.ncbi.nlm.nih.gov/pubmed/?term=22764774] | ISSN: | 1476-7058 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/28133 | Type: | Review | Subjects: | human insulin resistance/si [Side Effect] *intrauterine growth retardation nonhuman placenta circulation premature labor prenatal drug exposure priority journal review side effect/si [Side Effect] tissue Doppler imaging vasoconstriction betamethasone/ae [Adverse Drug Reaction] betamethasone/ct [Clinical Trial] *glucocorticoid/ae [Adverse Drug Reaction] *glucocorticoid/ct [Clinical Trial] myocardial performance index placenta insufficiency adaptation cardiovascular function cardiovascular parameters clinical assessment disease association Doppler echocardiography drug effect drug response *fetus heart fetus hypoxia fetus lung maturation fetus monitoring hemodynamic monitoring fetus hypoxia fetus lung maturation fetus monitoring hemodynamic monitoring human insulin resistance / side effect *intrauterine growth retardation nonhuman placenta circulation placenta insufficiency premature labor adaptation priority journal review side effect / side effect tissue Doppler imaging vasoconstriction prenatal drug exposure cardiovascular function cardiovascular parameters clinical assessment disease association Doppler echocardiography drug effect drug response *fetus heart |
Type of Clinical Study or Trial: | Review article (e.g. literature review, narrative review) |
Appears in Collections: | Articles |
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