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Title: | Corticosteroids, heart failure, and hypertension: A role for immune cells?. | Authors: | Shen J.Z.;Young M.J. | Institution: | (Shen, Young) Prince Henry's Institute of Medical Research, Monash University, Clayton, VIC 3168, Australia (Shen) Monash Medical Centre, Monash University, Clayton, VIC 3168, Australia (Young) Department of Physiology, Monash University, Clayton, VIC 3168, Australia (Shen, Young) Department of Medicine, Monash University, Clayton, VIC 3168, Australia | Issue Date: | 11-Dec-2012 | Copyright year: | 2012 | Publisher: | Endocrine Society (8401 Connecticut Ave. Suite 900, Chevy Chase MD 20815, United States) | Place of publication: | United States | Publication information: | Endocrinology. 153 (12) (pp 5692-5700), 2012. Date of Publication: 01 Dec 2012. | Abstract: | Aldosterone and its receptor the mineralocorticoid receptor (MR) are best known for their regulation of fluid and electrolyte homeostasis in epithelial cells. However, it is now clear that MR are also expressed in a broad range of nonepithelial tissues including the cardiovascular system. In the heart and vascular tissues, pathological activation of MR promotes cardiovascular inflammation and remodeling for which there is increasing evidence that macrophages and other immune cells (e.g. T cells and dendritic cells) play a significant role. While the glucocorticoids and their receptors have well-described antiinflammatory actions inimmunecells, a role for aldosterone and/or the MR in these cells is largely undefined. Emerging evidence, however, suggests that MR signaling may directly or indirectly promote proinflammatory responses in these immune cells. This review will discuss the current understanding of the role of corticosteroid receptors in macrophages and their effect on cardiovascular diseases involving inflammation. Copyright © 2012 by The Endocrine Society. | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1210/en.2012-1780 | PubMed URL: | 23125312 [http://www.ncbi.nlm.nih.gov/pubmed/?term=23125312] | ISSN: | 0013-7227 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/28179 | Type: | Short Survey |
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