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https://repository.monashhealth.org/monashhealthjspui/handle/1/28230| Title: | CD4 Th1 cells are effectors in lupus nephritis-But what are their targets. | Authors: | Ooi J.D.;Kitching A.R. | Institution: | (Ooi, Kitching) Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, 246 Clayton Road, Clayton, VIC 3168, Australia (Kitching) Department of Nephrology, Monash Medical Centre, Clayton, VIC, Australia (Kitching) Department of Pediatric Nephrology, Monash Medical Centre, Clayton, VIC, Australia | Issue Date: | 31-Oct-2012 | Copyright year: | 2012 | Publisher: | Nature Publishing Group (Houndmills, Basingstoke, Hampshire RG21 6XS, United Kingdom) | Place of publication: | United Kingdom | Publication information: | Kidney International. 82 (9) (pp 947-949), 2012. Date of Publication: 01 Nov 2012. | Abstract: | Lupus nephritis involves both humoral and cellular effectors. Okamoto and colleagues isolated renal CD4 cells from lupus-prone mice, selecting cells expressing T-cell receptors on the basis of their activity. After transfecting CD4 cells with the relevant T-cell receptors, they transferred them into mice and induced more severe glomerulonephritis. This study supports a direct role for Th1 cells in lupus nephritis, although their antigenic specificity remains uncertain, as they did not recognize nucleosomes. © 2012 International Society of Nephrology. | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1038/ki.2012.254 | PubMed URL: | 23064187 [http://www.ncbi.nlm.nih.gov/pubmed/?term=23064187] | ISSN: | 0085-2538 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/28230 | Type: | Review | Subjects: | nonhuman priority journal protein expression review systemic lupus erythematosus T lymphocyte *Th1 cell belimumab/dt [Drug Therapy] double stranded DNA/ec [Endogenous Compound] immunoglobulin/ec [Endogenous Compound] mycophenolic acid 2 morpholinoethyl ester/dt [Drug Therapy] T lymphocyte receptor/ec [Endogenous Compound] endothelium cell antigen specificity B lymphocyte *CD4+ T lymphocyte cellular immunity disease severity helper cell human humoral immunity immunoreactivity kidney interstitium *lupus erythematosus nephritis/dt [Drug Therapy] lupus erythematosus nephritis/dt [Drug Therapy] macrophage activation kidney interstitium *lupus erythematosus nephritis / *drug therapy lupus erythematosus nephritis / drug therapy macrophage activation nonhuman priority journal protein expression review B lymphocyte T lymphocyte *Th1 cell antigen specificity systemic lupus erythematosus *CD4+ T lymphocyte cellular immunity disease severity endothelium cell helper cell human humoral immunity immunoreactivity |
Type of Clinical Study or Trial: | Review article (e.g. literature review, narrative review) |
| Appears in Collections: | Articles |
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