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https://repository.monashhealth.org/monashhealthjspui/handle/1/28230| Title: | CD4 Th1 cells are effectors in lupus nephritis-But what are their targets. | Authors: | Ooi J.D.;Kitching A.R. | Institution: | (Ooi, Kitching) Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, 246 Clayton Road, Clayton, VIC 3168, Australia (Kitching) Department of Nephrology, Monash Medical Centre, Clayton, VIC, Australia (Kitching) Department of Pediatric Nephrology, Monash Medical Centre, Clayton, VIC, Australia | Issue Date: | 31-Oct-2012 | Copyright year: | 2012 | Publisher: | Nature Publishing Group (Houndmills, Basingstoke, Hampshire RG21 6XS, United Kingdom) | Place of publication: | United Kingdom | Publication information: | Kidney International. 82 (9) (pp 947-949), 2012. Date of Publication: 01 Nov 2012. | Abstract: | Lupus nephritis involves both humoral and cellular effectors. Okamoto and colleagues isolated renal CD4 cells from lupus-prone mice, selecting cells expressing T-cell receptors on the basis of their activity. After transfecting CD4 cells with the relevant T-cell receptors, they transferred them into mice and induced more severe glomerulonephritis. This study supports a direct role for Th1 cells in lupus nephritis, although their antigenic specificity remains uncertain, as they did not recognize nucleosomes. © 2012 International Society of Nephrology. | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1038/ki.2012.254 | PubMed URL: | 23064187 [http://www.ncbi.nlm.nih.gov/pubmed/?term=23064187] | ISSN: | 0085-2538 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/28230 | Type: | Review | Type of Clinical Study or Trial: | Review article (e.g. literature review, narrative review) |
| Appears in Collections: | Articles |
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