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https://repository.monashhealth.org/monashhealthjspui/handle/1/28291| Title: | Lenalidomide in multiple myeloma: Current status and future potential. | Authors: | Quach H.;Spencer A.;Kalff A. | Institution: | (Quach, Kalff, Spencer) Myeloma Research Group, Australian Centre for Blood Diseases, Monash University, Clayton, VIC, Australia (Quach) Department of Clinical Haematology, Monash Medical Centre, Clayton, VIC, Australia (Quach, Spencer) Department of Medicine, Nursing and Health Sciences, Monash University, Victoria, Australia (Kalff, Spencer) Department of Clinical Haematology, Alfred Hospital, Melbourne, VIC, Australia | Issue Date: | 27-Nov-2012 | Copyright year: | 2012 | Publisher: | Wiley-Liss Inc. (111 River Street, Hoboken NJ 07030-5774, United States) | Place of publication: | United States | Publication information: | American Journal of Hematology. 87 (12) (pp 1089-1095), 2012. Date of Publication: December 2012. | Abstract: | The clinical development of lenalidomide (RevlimidTM), then pomalidomide (ActimidTM) as members of immunomodulatory drugs (IMiDs) for the treatment of multiple myeloma (MM), exemplifies how insight into disease biology can lead to design of effective therapeutic agents. Increased experience and understanding of IMiD's diverse biological effects has lead to rational design of lenalidomide-based treatment-regimens over recent years. However, much about lenalidomide is yet to be understood and fully exploited. Here, we review what is known of lenalidomide's biological effects, clinical certainties and uncertainties in the treatment of MM, and explore its future potential with other synergistic therapeutic agents. © 2012 Wiley Periodicals, Inc. | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1002/ajh.23234 | PubMed URL: | 22641420 [http://www.ncbi.nlm.nih.gov/pubmed/?term=22641420] | ISSN: | 0361-8609 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/28291 | Type: | Review | Subjects: | stroma cell autologous stem cell transplantation cancer recurrence cell cycle arrest cytogenetics drug efficacy drug megadose drug potentiation drug safety human immunity immunomodulation infection/si [Side Effect] multiple myeloma/dt [Drug Therapy] *multiple myeloma/di [Diagnosis] *multiple myeloma/dt [Drug Therapy] *multiple myeloma/th [Therapy] neutropenia/si [Side Effect] phase 3 clinical trial (topic) priority journal randomized controlled trial (topic) review apoptosis thrombocytopenia/si [Side Effect] treatment duration treatment response venous thromboembolism/si [Side Effect] bortezomib/cb [Drug Combination] bortezomib/dt [Drug Therapy] dexamethasone/ae [Adverse Drug Reaction] dexamethasone/ct [Clinical Trial] dexamethasone/cb [Drug Combination] dexamethasone/it [Drug Interaction] dexamethasone/dt [Drug Therapy] *lenalidomide/ae [Adverse Drug Reaction] *lenalidomide/ct [Clinical Trial] *lenalidomide/cb [Drug Combination] *lenalidomide/it [Drug Interaction] *lenalidomide/dt [Drug Therapy] *lenalidomide/po [Oral Drug Administration] *lenalidomide/pd [Pharmacology] melphalan/ct [Clinical Trial] melphalan/cb [Drug Combination] melphalan/dt [Drug Therapy] pomalidomide/dt [Drug Therapy] prednisolone/ct [Clinical Trial] prednisolone/cb [Drug Combination] prednisolone/dt [Drug Therapy] prednisone/dt [Drug Therapy] thalidomide/dt [Drug Therapy] antineoplastic activity human immunity immunomodulation infection / side effect multiple myeloma / drug therapy *multiple myeloma / *diagnosis / *drug therapy / *therapy neutropenia / side effect phase 3 clinical trial (topic) priority journal randomized controlled trial (topic) review stroma cell thrombocytopenia / side effect treatment duration treatment response venous thromboembolism / side effect antineoplastic activity autologous stem cell transplantation cancer recurrence cell cycle arrest cytogenetics drug efficacy drug megadose drug potentiation drug safety apoptosis |
Type of Clinical Study or Trial: | Review article (e.g. literature review, narrative review) |
| Appears in Collections: | Articles |
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