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https://repository.monashhealth.org/monashhealthjspui/handle/1/28291| Title: | Lenalidomide in multiple myeloma: Current status and future potential. | Authors: | Quach H.;Spencer A.;Kalff A. | Institution: | (Quach, Kalff, Spencer) Myeloma Research Group, Australian Centre for Blood Diseases, Monash University, Clayton, VIC, Australia (Quach) Department of Clinical Haematology, Monash Medical Centre, Clayton, VIC, Australia (Quach, Spencer) Department of Medicine, Nursing and Health Sciences, Monash University, Victoria, Australia (Kalff, Spencer) Department of Clinical Haematology, Alfred Hospital, Melbourne, VIC, Australia | Issue Date: | 27-Nov-2012 | Copyright year: | 2012 | Publisher: | Wiley-Liss Inc. (111 River Street, Hoboken NJ 07030-5774, United States) | Place of publication: | United States | Publication information: | American Journal of Hematology. 87 (12) (pp 1089-1095), 2012. Date of Publication: December 2012. | Abstract: | The clinical development of lenalidomide (RevlimidTM), then pomalidomide (ActimidTM) as members of immunomodulatory drugs (IMiDs) for the treatment of multiple myeloma (MM), exemplifies how insight into disease biology can lead to design of effective therapeutic agents. Increased experience and understanding of IMiD's diverse biological effects has lead to rational design of lenalidomide-based treatment-regimens over recent years. However, much about lenalidomide is yet to be understood and fully exploited. Here, we review what is known of lenalidomide's biological effects, clinical certainties and uncertainties in the treatment of MM, and explore its future potential with other synergistic therapeutic agents. © 2012 Wiley Periodicals, Inc. | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1002/ajh.23234 | PubMed URL: | 22641420 [http://www.ncbi.nlm.nih.gov/pubmed/?term=22641420] | ISSN: | 0361-8609 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/28291 | Type: | Review | Type of Clinical Study or Trial: | Review article (e.g. literature review, narrative review) |
| Appears in Collections: | Articles |
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