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Conference/Presentation Title: | Biomarkers of Asthma Relapse and Lung Function Decline in Adults with Remitted Asthma: A Population-Based Cohort Study. | Authors: | Abramson M.;Tang M.;Walters H.;Dharmage S.;Perret J.;Tan D.;Lodge C.;Lowe A.;Aldakheel F.;Bui D.;Johns D.;Hamilton G. ;Thomas P. | Institution: | (Tan, Lodge, Lowe, Bui, Walters, Perret, Dharmage) Allergy and Lung Health Unit, Melbourne School of Population and Global Health, University of Melbourne (Aldakheel) Department of Clinical Laboratory Sciences, King Saud University (Johns) School of Medicine, University of Tasmania (Hamilton) Monash Lung and Sleep, Monash Health (Thomas) University of New South Wales (Tang) Murdoch Childrenas Research Institute, University of Melbourne (Abramson) School of Public Health and Preventive Medicine, Monash University | Presentation/Conference Date: | 7-Jan-2021 | Copyright year: | 2020 | Publisher: | Blackwell Publishing | Publication information: | Respirology. Conference: TSANZSRS 2020 Australia and New Zealand Society of Respiratory Science and the Thoracic Society of Australia and New Zealand Annual Scientific Meeting, ANZSRS/TSANZ. Melbourne, VIC Australia. 25 (pp 70), 2020. Date of Publication: June 2020. | Abstract: | Introduction. Whether systemic and airway inflammation persist in remitted asthma and whether such inflammation is associated with adverse long-term respiratory outcomes remains unclear. Objective. To determine the prevalence of systemic and airway inflammation in adults with remitted asthma, and to examine their associations with asthma relapse and lung function decline. Methods. The Tasmanian Longitudinal Health Study (TAHS) is a population-based cohort first studied in 1968 (n = 8,583). In 2004 (age 44), biomarkers of systemic inflammation (serum IL-4, IL-5, IL-6, IL-8, IL10, TNF-) were measured in a subgroup (n = 1,389) and categorised into cytokine profiles using latent profile analysis (LPA). In 2010 (age 50), markers of airway inflammation, methacholine challenge tests (n = 836) and total nitric oxide products in exhaled breath condensate (EBC NOx), were measured. Asthma relapse and lung function decline were assessed at follow-up in 2014. Multivariable linear and Poisson regression were used to examine relevant associations. Results. Of adults with remitted asthma at age 50 years, 20.8% [95% CI 15.9, 26.7] had bronchial hyperresponsiveness (BHR) and 7.1% [95% CI 4.2 ,11.9] had an elevated EBC NOx (>5.05 mumol/L). Asthma relapse was associated with BHR (RR 2.25 [95%CI 1.52, 3.32]), but not with elevated EBC NOx. Three distinct cytokine profiles were identified via LPA: A reference anormala cytokine profile, a aTh2-higha profile associated with accelerated post-BD FEV1/FVC decline (MD-0.18% predicted/year [-0.33,-0.02]), and a aTh2-lowa profile associated with accelerated postBD FEV1 (MD-0.41% predicted/year [-0.75,-0.06]) and post-BD FVC decline (MD-0.31% predicted/year [-0.62, 0.01]). Conclusion. BHR and elevated biomarkers of asthma activity have prognostic value in adults with remitted asthma. At-risk individuals may benefit from closer follow-up, repeat spirometry and potentially antiinflammatory agents. | Conference Start Date: | 2020-03-27 | Conference End Date: | 2020-03-31 | DOI: | http://monash.idm.oclc.org/login?url= http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1111/resp.13777 |
ISSN: | 1323-7799 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/28737 | Type: | Conference Abstract | Subjects: | conference abstract controlled study drug therapy female follow up forced expiratory volume forced vital capacity human human tissue *lung function major clinical study male prevalence provocation test *relapse *remission adult spirometry *biological marker endogenous compound interleukin 10 interleukin 4 interleukin 5 interleukin 6 interleukin 8 methacholine nitric oxide tumor necrosis factor *asthma respiratory tract inflammation bronchus hyperreactivity *cohort analysis *lung function major clinical study male prevalence provocation test *relapse *remission respiratory tract inflammation spirometry female follow up controlled study conference abstract *cohort analysis bronchus hyperreactivity drug therapy forced expiratory volume forced vital capacity human human tissue *asthma adult |
Type of Clinical Study or Trial: | Observational study (cohort, case-control, cross sectional or survey) |
Appears in Collections: | Conferences |
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