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Title: | The Australian Cancer Anaemia Survey: A snapshot of anaemia in adult patients with cancer. | Authors: | Morton J.;Taylor K.;Love A.;Slancar M.;Sullivan J.;Seshadri T.;Prince H.M.;Bell D.R.;Coughlin P.B.;James P.P.B.;Richardson G.E.;Chern B.;Briggs P. ;Norman J.;Olver I.N.;Karapetis C.;Stewart J.;Beadle G.;Bell R. ;Brodribb R.;Byrne M.;Dalley D.;Driver N.;Ganju V.;Lindeman R. | Institution: | (Seshadri, Prince) Haematology Service, Peter MacCallum Centre, A'Beckett St., Melbourne, Vic. 8006, Australia (Bell) Royal North Shore Hospital, Department of Medical Oncology, Sydney, NSW, Australia (Coughlin) Box Hill Hospital, Haemostasis/Thrombosis Unit, Box Hill, Vic., Australia (James) Maroondah Hospital, Oncology Unit, Ringwood East, Vic., Australia (Richardson) Cabrini Hospital, Department of Medical Oncology, Melbourne, Vic., Australia (Chern) Redcliffe Hospital, Department of Medical Oncology and Palliative Care, Brisbane, QLD, Australia (Briggs) Monash Medical Centre, Department of Oncology, Melbourne, Vic., Australia (Norman) Queen Elizabeth Hospital, Adelaide, SA, Australia (Olver) Royal Adelaide Hospital, Department of Oncology, Adelaide, SA, Australia (Karapetis) Flinders Medical Centre, Adelaide, SA, Australia (Stewart) Mater Hospital, Newcastle, NSW, Australia (Beadle) Wesley Hospital, Brisbane, QLD, Australia (Bell) Geelong Hospital, Geelong, Vic., Australia (Brodribb) Toowoomba Base Hospital, Toowoomba, QLD, Australia (Byrne) Sir Charles Gairdner Hospital, Perth, WA, Australia (Dalley) St. Vincents Hospital, Lismore, NSW, Australia (Driver) Westmead Private Hospital, Sydney, NSW, Australia (Ganju) Frankston Hospital, Frankston, Vic., Australia (Lindeman) Prince of Wales Hospital, Sydney, NSW, Australia (Love) Nambour General Hospital, Brisbane, QLD, Australia (Morton) St. Andrews Hospital, Toowoomba, QLD, Australia (Slancar) Gold Coast Hospital, Gold Coast, QLD, Australia (Sullivan) Freemasons Hospital, Melbourne, Vic., Australia (Taylor) Mater Public Hospital, Brisbane, QLD, Australia | Issue Date: | 17-Oct-2012 | Copyright year: | 2005 | Publisher: | Australasian Medical Publishing Co. Ltd (Level 2, 26-32 Pyrmont Bridge Road, Pyrmont NSW 2009, Australia) Australasian Medical Publishing Co. Ltd |
Place of publication: | Australia | Publication information: | Medical Journal of Australia. 182 (9) (pp 453-457), 2005. Date of Publication: 02 May 2005. | Journal: | Medical Journal of Australia | Abstract: | Objective: To evaluate the frequency and management of anaemia in Australian adults with solid and haematological malignancies. Design(s): 6-month observational, prospective, multicentre study. Participant(s): 694 patients recruited from outpatient oncology clinics in 24 hospitals in five Australian states between 9 April 2001 and 31 July 2001. Main Outcome Measure(s): Frequency of anaemia (haemoglobin [Hb] level < 120 g/L) at enrolment and over ensuing 6 months, by tumour type, disease status and cancer treatment; anaemia treatment and "trigger" Hb level for this treatment. Result(s): Participants had median age 60 years, and 61% were women. Prevalence of anaemia at enrolment was 35% (199/562), with 78% of these 199 having mild anaemia (Hb, 100-119 g/L). Frequency of anaemia (either present at enrolment or developing during the study) was 57% overall (323/566), and varied with tumour type, from 49% (lymphoma/myeloma) to 85% (urogenital cancer). Patients who received radiotherapy either in combination or concomitant with chemotherapy were more likely to have anaemia (73%) than those receiving chemotherapy alone (58%) (P=0.004). Of all chemotherapy patients not anaemic at enrolment, 23% developed anaemia by the second monthly follow-up. Independent predictors for anaemia in chemotherapy patients were low baseline Hb level (odds ratio [OR], 5.4; 95% CI, 2.7-10.9) and use of platinum chemotherapeutic agents (OR, 4.8; 95% CI, 2.1-11.4) (P<0.001). Anaemia was treated in 41% of patients with anaemia at enrolment - by transfusion (36%), iron (5%) and erythropoietic agents (2%). Frequency of anaemia treatment varied between tumour types, from 19% (breast cancer) to 60% (leukaemia). The mean "trigger Hb" for initiating transfusion was 95 g/L. Conclusion(s): Anaemia is prevalent among Australian patients with cancer managed in hospital oncology units. Its management varies between tumour types. Many patients do not receive treatment for their anaemia. | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.5694/j.1326-5377.2005.tb06784.x | PubMed URL: | 15865588 [http://www.ncbi.nlm.nih.gov/pubmed/?term=15865588] | ISSN: | 0025-729X | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/28745 | Type: | Article | Subjects: | *solid tumor/dt [Drug Therapy] adolescent adult aged *anemia/co [Complication] *anemia/dt [Drug Therapy] *anemia/th [Therapy] article Australia blood transfusion breast cancer/dt [Drug Therapy] breast cancer/rt [Radiotherapy] cancer combination chemotherapy clinical trial confidence interval disease severity female follow up *health survey *hematologic malignancy/dt [Drug Therapy] *hematologic malignancy/rt [Radiotherapy] hemoglobin determination human iron therapy leukemia/dt [Drug Therapy] leukemia/rt [Radiotherapy] lymphoma/dt [Drug Therapy] lymphoma/rt [Radiotherapy] major clinical study male multicenter study myeloma/dt [Drug Therapy] myeloma/rt [Radiotherapy] prediction prevalence prospective study rank sum test *solid tumor/rt [Radiotherapy] treatment outcome urogenital tract cancer/dt [Drug Therapy] urogenital tract cancer/rt [Radiotherapy] antineoplastic agent/ct [Clinical Trial] antineoplastic agent/dt [Drug Therapy] erythropoietin/ct [Clinical Trial] erythropoietin/dt [Drug Therapy] iron/ct [Clinical Trial] iron/dt [Drug Therapy] blood transfusion breast cancer / drug therapy / radiotherapy cancer combination chemotherapy clinical trial confidence interval disease severity female follow up *health survey *hematologic malignancy / *drug therapy / *radiotherapy hemoglobin determination human iron therapy leukemia / drug therapy / radiotherapy lymphoma / drug therapy / radiotherapy rank sum test prospective study prevalence male treatment outcome major clinical study adolescent adult aged *anemia / *complication / *drug therapy / *therapy article Australia prediction myeloma / drug therapy / radiotherapy *solid tumor / *drug therapy / *radiotherapy multicenter study urogenital tract cancer / drug therapy / radiotherapy |
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