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Title: | Management of early-stage gastro-esophageal cancers: expert perspectives from the Australasian Gastrointestinal Trials Group (AGITG) with invited international faculty. | Authors: | Lordick F.;Chen L.-T.;Barbour A.;Tebbutt N.;Price T.;Roy A.C.;Shapiro J.;Burge M.;Karapetis C.S.;Pavlakis N.;Segelov E. ;Chau I. | Monash Health Department(s): | Oncology | Institution: | (Roy, Karapetis) Flinders Centre for Innovation in Cancer, Flinders University, Bedford Park, Australia (Shapiro) Cabrini Health, Monash University, Melbourne, Australia (Burge) Department of Cancer Care Services, Royal Brisbane Hospital, University Of Queensland, Herston, Australia (Pavlakis) Department of Medical Oncology, Royal North Shore Hospital, Sydney, Australia (Segelov) Department of Medical Oncology, Monash University and Monash Health, Melbourne, Australia (Chau) Department of Medical Oncology, Royal Marsden Hospital, Institute of Cancer Research, Surrey, London, United Kingdom (Lordick) Leipzig University Medical Centre, University Cancer Centre Leipzig, Leipzig, Germany (Chen) National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan (Republic of China) (Barbour) The University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, Australia (Tebbutt) Department of Medical Oncology, Austin Health, Heidelberg, Australia (Price) Queen Elizabeth Hospital, University of Adelaide, Adelaide, Australia | Issue Date: | 2-May-2020 | Copyright year: | 2020 | Publisher: | Taylor and Francis Ltd | Place of publication: | United Kingdom | Publication information: | Expert Review of Anticancer Therapy. 20 (4) (pp 305-324), 2020. Date of Publication: 02 Apr 2020. | Journal: | Expert Review of Anticancer Therapy | Abstract: | Introduction: A multimodal approach in operable early-stage oesophago-gastric (OG) cancer has evolved in the last decade, leading to improvement in overall outcomes. Areas covered: A review of the published literature and conference abstracts was undertaken on the topic of optimal adjunctive chemotherapy or chemoradiotherapy in early-stage OG cancers. This review article focuses on the current evidence pertaining to neoadjuvant and perioperative strategies in curable OG cancers including the evolving landscape of immunotherapy and targeted drugs in this setting. Expert commentary: Adjunctive therapies in the form of preoperative chemo-radiotherapy (CRT) or chemotherapy and perioperative chemotherapy over surgery alone improve outcomes in patients with operable OG cancer. Although there are variations in practice around the world, a multi-disciplinary approach to patient care is of paramount importance. Immunotherapy and on treatment functional imaging are two examples of emerging strategies to improve the outcome for early-stage patients. A better understanding of the molecular biology of this disease may help overcome the problem of tumor heterogeneity and enable more rationally designed and targeted therapeutic interventions in the future.Copyright © 2020, © 2020 Informa UK Limited, trading as Taylor & Francis Group. | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1080/14737140.2020.1746185 | PubMed URL: | 32202178 [http://www.ncbi.nlm.nih.gov/pubmed/?term=32202178] | ISSN: | 1473-7140 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/28901 | Type: | Review | Subjects: | *stomach cancer/rt [Radiotherapy] *stomach cancer/su [Surgery] bevacizumab/ct [Clinical Trial] bevacizumab/dt [Drug Therapy] capecitabine/ct [Clinical Trial] capecitabine/cb [Drug Combination] capecitabine/dt [Drug Therapy] carboplatin/ct [Clinical Trial] carboplatin/cb [Drug Combination] carboplatin/dt [Drug Therapy] cisplatin/ct [Clinical Trial] cisplatin/cb [Drug Combination] cisplatin/dt [Drug Therapy] docetaxel/ct [Clinical Trial] docetaxel/cb [Drug Combination] docetaxel/dt [Drug Therapy] epirubicin/ct [Clinical Trial] epirubicin/cb [Drug Combination] epirubicin/dt [Drug Therapy] fluorouracil/ct [Clinical Trial] fluorouracil/cb [Drug Combination] fluorouracil/dt [Drug Therapy] gimeracil plus oteracil potassium plus tegafur/ct [Clinical Trial] gimeracil plus oteracil potassium plus tegafur/cb [Drug Combination] gimeracil plus oteracil potassium plus tegafur/dt [Drug Therapy] oxaliplatin/ct [Clinical Trial] oxaliplatin/cb [Drug Combination] paclitaxel/ct [Clinical Trial] paclitaxel/cb [Drug Combination] paclitaxel/dt [Drug Therapy] vinorelbine tartrate/ct [Clinical Trial] vinorelbine tartrate/cb [Drug Combination] vinorelbine tartrate/dt [Drug Therapy] *gastroesophageal cancer/dt [Drug Therapy] *gastroesophageal cancer/rt [Radiotherapy] *gastroesophageal cancer/su [Surgery] oxaliplatin/dt [Drug Therapy] cancer adjuvant therapy cancer immunotherapy cancer staging cancer surgery chemoradiotherapy computer assisted tomography endoscopic ultrasonography esophageal squamous cell carcinoma/rt [Radiotherapy] esophageal squamous cell carcinoma/su [Surgery] *esophagus cancer/dt [Drug Therapy] *esophagus cancer/rt [Radiotherapy] *esophagus cancer/su [Surgery] external beam radiotherapy geography human multimodality cancer therapy multiple cycle treatment outcome assessment overall survival patient care patient selection perioperative period review *stomach cancer/dt [Drug Therapy] stomach cancer bevacizumab/ct bevacizumab capecitabine/ct capecitabine carboplatin/ct carboplatin cisplatin/ct cisplatin docetaxel/ct docetaxel epirubicin/ct epirubicin fluorouracil/ct fluorouracil gimeracil plus oteracil potassium plus tegafur/ct gimeracil plus oteracil potassium plus tegafur oxaliplatin/ct oxaliplatin paclitaxel/ct paclitaxel vinorelbine tartrate/ct vinorelbine tartrate gastroesophageal cancer oxaliplatin cancer adjuvant therapy cancer immunotherapy cancer staging cancer surgery chemoradiotherapy computer assisted tomography endoscopic ultrasonography esophageal squamous cell carcinoma esophagus cancer external beam radiotherapy geography multimodality cancer therapy multiple cycle treatment patient care patient selection perioperative period stomach cancer geography human multimodality cancer therapy multiple cycle treatment outcome assessment overall survival patient care patient selection cancer adjuvant therapy Review *stomach cancer / *drug therapy / *radiotherapy / *surgery perioperative period cancer immunotherapy cancer staging cancer surgery chemoradiotherapy computer assisted tomography endoscopic ultrasonography esophageal squamous cell carcinoma / radiotherapy / surgery *esophagus cancer / *drug therapy / *radiotherapy / *surgery external beam radiotherapy |
Type of Clinical Study or Trial: | Review article (e.g. literature review, narrative review) |
Appears in Collections: | Articles |
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