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https://repository.monashhealth.org/monashhealthjspui/handle/1/28920| Title: | Application of the a 5-2-1' screening criteria in advanced Parkinson's disease: Interim analysis of DUOGLOBE. | Authors: | Bajenaru O.;Bergmann L.;Bourgeois P.;Cubo E.;Davis T.L.;Iansek R. ;Kovacs N.;Kukreja P.;Onuk K.;Pontieri F.E.;Robieson W.;Siddiqui M.S.;Simu M.;Standaert D.G.;Ray Chaudhuri K.;Aldred J.;Anca-Herschkovitsch M.;Antonini A. | Institution: | (Aldred) Selkirk Neurology and Inland Northwest Research, Spokane, 610 S Sherman St #201 and 208, Spokane, WA 99202, United States (Anca-Herschkovitsch) Department of Neurology, Edith Wolfson Medical Center, Tel Aviv University, 62 Ha-Lokhamim St, Holon, Israel (Antonini) Department of Neuroscience, Padua University, Padova, Padua, Veneto 5-35128, Italy (Bajenaru) Department of Neurology, University of Medicine and Pharmacy Carol Davila, Bulevardul Eroii Sanitari 8, Bucharest, Romania (Bergmann, Kukreja, Onuk, Robieson) AbbVie Inc., 1 Waukegan Rd, North Chicago, IL 60064, United States (Bourgeois) Department of Neurology Az Groeninge, President Kennedylaan 4, Kortrijk, Belgium (Cubo) Neurology Department, Hospital Universitario Burgos, Av. Islas Baleares, 3, Burgos, Spain (Davis) Department of Neurology, Vanderbilt University Medical Center, 1211 Medical Center Dr, Nashville, TN 37232, United States (Iansek) Kingston Centre, Monash Health, 400 Warrigal Rd, Melbourne, VIC, Australia (Kovacs) Department of Neurology, University of Pecs, 48-as ter 1, Pecs, Hungary (Pontieri) Department of Neurological Sciences, Sapienza University of Rome, Piazzale Aldo Moro, 5, Rome, Italy (Siddiqui) Department of Neurology, Wake Forest School of Medicine, 475 Vine St, Winston Salem, NC 27101, United States (Simu) Department of Neurology, Victor Babes University of Medicine and Pharmacy, Piata Eftimie Murgu 2, Timisoara, Romania (Standaert) Department of Neurology, University of Alabama at Birmingham, 1720 University Blvd, Birmingham, AL 35294, United States (Ray Chaudhuri) Parkinson Foundation International Centre of Excellence, King's College and King's College Hospital, Denmark Hill, London, United Kingdom | Issue Date: | 21-Nov-2020 | Copyright year: | 2020 | Publisher: | Future Medicine Ltd. | Place of publication: | United Kingdom | Publication information: | Neurodegenerative Disease Management. 10 (5) (pp 309-323), 2020. Date of Publication: October 2020. | Journal: | Neurodegenerative Disease Management | Abstract: | Aim: A Delphi expert consensus panel proposed that fulfilling >=1 of the a 5-2-1 criteria' (>=five-times daily oral levodopa use, >=two daily hours with a Off' symptoms or >=one daily hour with troublesome dyskinesia) suggests advanced Parkinson's disease (PD). Patients & methods: DUOdopa/Duopa in Patients with Advanced PD-a GLobal OBservational Study Evaluating Long-Term Effectiveness (DUOGLOBE)-is a single-arm, postmarketing, observational, long-term effectiveness study of levodopa-carbidopa intestinal gel (LCIG) for advanced PD. Result(s): This 6-month interim analysis (n = 139) affirms that most (98%) enrolled patients fulfill >=1 of the 5-2-1 criteria. These patients responded favorably to LCIG treatment. Safety was consistent with other LCIG studies. Conclusion(s): In advanced PD patients, the 5-2-1 criteria generally aligns with clinician assessment.Copyright © 2020 AbbVie Inc., employer of authors L Bergmann, P Kukreja, K Onuk, W Robieson. | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.2217/nmt-2020-0021 | PubMed URL: | 32873195 [http://www.ncbi.nlm.nih.gov/pubmed/?term=32873195] | ISSN: | 1758-2024 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/28920 | Type: | Article | Subjects: | *carbidopa plus levodopa/dt [Drug Therapy] *carbidopa plus levodopa/ig [Intragastric Drug Administration] levodopa/do [Drug Dose] levodopa/dt [Drug Therapy] levodopa/po [Oral Drug Administration] femoral neck fracture/si [Side Effect] aged article brain depth stimulation Caregiver Strain Index clinical article decubitus/si [Side Effect] Delphi study drug efficacy drug safety drug withdrawal dyskinesia female human male Mini Mental State Examination multicenter study observational study outcome assessment *Parkinson disease/dt [Drug Therapy] pneumonia/si [Side Effect] pneumoperitoneum/si [Side Effect] polyneuropathy/si [Side Effect] post hoc analysis postmarketing surveillance priority journal Unified Parkinson Disease Rating Scale urinary tract infection/si [Side Effect] apomorphine *carbidopa plus levodopa/ae [Adverse Drug Reaction] *carbidopa plus levodopa/ct [Clinical Trial] dyskinesia female femoral neck fracture / side effect human male Mini Mental State Examination multicenter study observational study outcome assessment *Parkinson disease / *drug therapy pneumonia / side effect pneumoperitoneum / side effect polyneuropathy / side effect post hoc analysis postmarketing surveillance priority journal Unified Parkinson Disease Rating Scale Article aged urinary tract infection / side effect brain depth stimulation Caregiver Strain Index clinical article decubitus / side effect Delphi study drug efficacy drug safety drug withdrawal |
Type of Clinical Study or Trial: | Observational study (cohort, case-control, cross sectional or survey) |
| Appears in Collections: | Articles |
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