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https://repository.monashhealth.org/monashhealthjspui/handle/1/29200| Title: | COVID-19 and toxicity from potential treatments: Panacea or poison. | Authors: | Wong A. | Monash Health Department(s): | Monash University - School of Clinical Sciences at Monash Health | Institution: | (Wong) Victorian Poisons Information Centre, Austin Toxicology Unit and Emergency Department, Austin Health, Melbourne, VIC, Australia (Wong) Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Melbourne, VIC, Australia (Wong) Centre for Integrated Critical Care, Melbourne Medical School, The University of Melbourne, Melbourne, VIC, Australia | Issue Date: | 30-Jul-2020 | Copyright year: | 2020 | Publisher: | Blackwell Publishing | Place of publication: | Australia | Publication information: | EMA - Emergency Medicine Australasia. 32 (4) (pp 697-699), 2020. Date of Publication: 01 Aug 2020. | Journal: | EMA - Emergency Medicine Australasia | Abstract: | Since December 2019, coronavirus disease (COVID-19) has been increasingly spreading from its origin in Wuhan, China to many countries around the world eventuating in morbidity and mortality affecting millions of people. This pandemic has proven to be a challenge given that there is no immediate cure, no vaccine is currently available and medications or treatments being used are still undergoing clinical trials. There have already been examples of self-medication and overdose. Clearly, there is a need to further define the efficacy of treatments used in the management of COVID-19. This evidence needs to be backed by large randomised-controlled clinical trials. In the meantime, there will no doubt be further off-label use of these medications by patients and practitioners and possibly related toxicity.Copyright © 2020 Australasian College for Emergency Medicine | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1111/1742-6723.13537 | PubMed URL: | 32378805 [http://www.ncbi.nlm.nih.gov/pubmed/?term=32378805] | ISSN: | 1742-6731 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/29200 | Type: | Article | Subjects: | bone marrow suppression/si [Side Effect] China coma/si [Side Effect] convulsion/si [Side Effect] *coronavirus disease 2019/dt [Drug Therapy] diarrhea/si [Side Effect] drug efficacy drug overdose drug research evidence based medicine gastrointestinal symptom/si [Side Effect] headache/si [Side Effect] heart arrhythmia/si [Side Effect] human hypertransaminasemia/si [Side Effect] hypokalemia/si [Side Effect] hypotension/si [Side Effect] kidney dysfunction/si [Side Effect] liver injury/si [Side Effect] morbidity mortality nonhuman pancreatitis/si [Side Effect] pandemic patient safety priority journal QT prolongation/si [Side Effect] rash/si [Side Effect] self medication treatment outcome virus load virus transmission activated carbon/dt [Drug Therapy] azithromycin/ae [Adverse Drug Reaction] drug intoxication/dt [Drug Therapy] azithromycin/cb [Drug Combination] azithromycin/dt [Drug Therapy] azithromycin/pv [Special Situation for Pharmacovigilance] ceftriaxone/cb [Drug Combination] ceftriaxone/dt [Drug Therapy] ceftriaxone/pv [Special Situation for Pharmacovigilance] chloroquine/ae [Adverse Drug Reaction] chloroquine/cb [Drug Combination] chloroquine/do [Drug Dose] chloroquine/dt [Drug Therapy] article atrioventricular block/si [Side Effect] bleeding/si [Side Effect] chloroquine/pv [Special Situation for Pharmacovigilance] colchicine/do [Drug Dose] colchicine/dt [Drug Therapy] colchicine/to [Drug Toxicity] colchicine/pv [Special Situation for Pharmacovigilance] hydroxychloroquine/ae [Adverse Drug Reaction] hydroxychloroquine/cb [Drug Combination] hydroxychloroquine/do [Drug Dose] hydroxychloroquine/dt [Drug Therapy] hydroxychloroquine/pv [Special Situation for Pharmacovigilance] ivermectin/do [Drug Dose] ivermectin/dt [Drug Therapy] ivermectin/to [Drug Toxicity] lopinavir plus ritonavir/ae [Adverse Drug Reaction] lopinavir plus ritonavir/do [Drug Dose] lopinavir plus ritonavir/dt [Drug Therapy] lopinavir plus ritonavir/to [Drug Toxicity] lopinavir plus ritonavir/pv [Special Situation for Pharmacovigilance] remdesivir/ae [Adverse Drug Reaction] remdesivir/dt [Drug Therapy] remdesivir/pv [Special Situation for Pharmacovigilance] thalidomide/do [Drug Dose] thalidomide/dt [Drug Therapy] thalidomide/to [Drug Toxicity] thalidomide/pv [Special Situation for Pharmacovigilance] tocilizumab/ae [Adverse Drug Reaction] tocilizumab/dt [Drug Therapy] tocilizumab/pv [Special Situation for Pharmacovigilance] bone marrow suppression China coma convulsion coronavirus disease 2019 diarrhea drug efficacy drug overdose drug research evidence based medicine gastrointestinal symptom headache heart arrhythmia hypertransaminasemia hypokalemia hypotension kidney dysfunction liver injury pancreatitis pandemic patient safety QT prolongation rash self medication virus load virus transmission activated carbon azithromycin [Adverse Drug Reaction] drug intoxication azithromycin ceftriaxone chloroquine [Adverse Drug Reaction] chloroquine atrioventricular block colchicine hydroxychloroquine [Adverse Drug Reaction] hydroxychloroquine ivermectin lopinavir plus ritonavir [Adverse Drug Reaction] lopinavir plus ritonavir remdesivir [Adverse Drug Reaction] remdesivir thalidomide tocilizumab [Adverse Drug Reaction] tocilizumab drug efficacy drug intoxication / drug therapy drug overdose drug research evidence based medicine gastrointestinal symptom / side effect headache / side effect heart arrhythmia / side effect human hypertransaminasemia / side effect hypokalemia / side effect hypotension / side effect kidney dysfunction / side effect liver injury / side effect morbidity mortality nonhuman pancreatitis / side effect pandemic patient safety priority journal rash / side effect self medication treatment outcome virus load virus transmission QT prolongation / side effect Article atrioventricular block / side effect bleeding / side effect bone marrow suppression / side effect China coma / side effect convulsion / side effect *coronavirus disease 2019 / *drug therapy diarrhea / side effect |
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