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Title: | Cardiovascular response and sequelae after minimally invasive surfactant therapy in growth-restricted preterm infants. | Authors: | Bhatia R. ;Roberts C.T.;Sehgal A. | Monash Health Department(s): | Paediatric - Neonatal (Monash Newborn) | Institution: | (Sehgal, Bhatia, Roberts) Monash Newborn, Monash Children's Hospital, Melbourne, Vic, Australia (Sehgal, Bhatia, Roberts) Department of Paediatrics, Monash University, Melbourne, Vic, Australia | Issue Date: | 7-Aug-2020 | Copyright year: | 2020 | Publisher: | Springer Nature | Place of publication: | United States | Publication information: | Journal of Perinatology. 40 (8) (pp 1178-1184), 2020. Date of Publication: 01 Aug 2020. | Journal: | Journal of Perinatology | Abstract: | Objective: To study cardiovascular response to minimally invasive surfactant therapy in preterm infants with and without foetal growth restriction (FGR). Design(s): Poractant alfa was administered and echocardiograms were performed before and 30 min after. FGR infants were compared with those appropriate for gestational age (AGA). Result(s): Ten FGR infants were compared with 20 AGA infants (gestation [weeks], 28.9 +/- 2 vs. 28.6 +/- 1, p = 0.55 and birthweight [g], 813 +/- 157 vs. 1141 +/- 257, p = 0.01, respectively). The change in echocardiographic parameters was more prominent in AGA infants ([global contractility] fractional area change [FAC, %], FGR, 24.7 +/- 2.2 to 27.9 +/- 0.4, p = 0.08 vs. AGA, 26.6 +/- 3 to 30.5 +/- 1, p < 0.01, and [longitudinal contractility] tricuspid annular plane systolic excursion [mm], FGR, 3.9 +/- 0.3 to 4.6 +/- 0.5, p = 0.003 vs. AGA, 4.6 +/- 0.3 to 5.5 +/- 0.4, p = 0.0001). Significant difference was noted for change in FAC (%), FGR 2.1 +/- 1.7 vs. AGA 4.1 +/- 1.2, p = 0.02. Conclusion(s): Differential cardiovascular response to minimally invasive surfactant therapy amongst FGR infants may reflect an in-utero maladaptive state.Copyright © 2020, The Author(s), under exclusive licence to Springer Nature America, Inc. | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1038/s41372-020-0682-5 | PubMed URL: | 32377011 [http://www.ncbi.nlm.nih.gov/pubmed/?term=32377011] | ISSN: | 0743-8346 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/29202 | Type: | Article | Subjects: | newborn observational study outcome assessment *prematurity treatment response tricuspid annular plane systolic excursion atropine/iv [Intravenous Drug Administration] atropine/pv [Special Situation for Pharmacovigilance] caffeine citrate/iv [Intravenous Drug Administration] caffeine citrate/pv [Special Situation for Pharmacovigilance] *poractant/pv [Special Situation for Pharmacovigilance] echocardiograph peripheral venous catheter fractional area change Vivid E95 echocardiography article birth weight cardiovascular parameters *cardiovascular response clinical article controlled study female fetus gestational age human infant *intrauterine growth retardation lung hemodynamics male *minimally invasive procedure newborn prematurity tricuspid annular plane systolic excursion atropine caffeine citrate poractant echocardiograph peripheral venous catheter fractional area change Vivid E95 echocardiography birth weight cardiovascular parameters cardiovascular response fetus gestational age infant intrauterine growth retardation lung hemodynamics minimally invasive procedure infant *intrauterine growth retardation lung hemodynamics male *minimally invasive procedure newborn observational study outcome assessment cardiovascular parameters treatment response tricuspid annular plane systolic excursion birth weight Article *prematurity *cardiovascular response clinical article controlled study echocardiography female fetus gestational age human |
Type of Clinical Study or Trial: | Observational study (cohort, case-control, cross sectional or survey) |
Appears in Collections: | Articles |
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