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Title: | Cardiovascular response and sequelae after minimally invasive surfactant therapy in growth-restricted preterm infants. | Authors: | Bhatia R. ;Roberts C.T.;Sehgal A. | Monash Health Department(s): | Paediatric - Neonatal (Monash Newborn) | Institution: | (Sehgal, Bhatia, Roberts) Monash Newborn, Monash Children's Hospital, Melbourne, Vic, Australia (Sehgal, Bhatia, Roberts) Department of Paediatrics, Monash University, Melbourne, Vic, Australia | Issue Date: | 7-Aug-2020 | Copyright year: | 2020 | Publisher: | Springer Nature | Place of publication: | United States | Publication information: | Journal of Perinatology. 40 (8) (pp 1178-1184), 2020. Date of Publication: 01 Aug 2020. | Journal: | Journal of Perinatology | Abstract: | Objective: To study cardiovascular response to minimally invasive surfactant therapy in preterm infants with and without foetal growth restriction (FGR). Design(s): Poractant alfa was administered and echocardiograms were performed before and 30 min after. FGR infants were compared with those appropriate for gestational age (AGA). Result(s): Ten FGR infants were compared with 20 AGA infants (gestation [weeks], 28.9 +/- 2 vs. 28.6 +/- 1, p = 0.55 and birthweight [g], 813 +/- 157 vs. 1141 +/- 257, p = 0.01, respectively). The change in echocardiographic parameters was more prominent in AGA infants ([global contractility] fractional area change [FAC, %], FGR, 24.7 +/- 2.2 to 27.9 +/- 0.4, p = 0.08 vs. AGA, 26.6 +/- 3 to 30.5 +/- 1, p < 0.01, and [longitudinal contractility] tricuspid annular plane systolic excursion [mm], FGR, 3.9 +/- 0.3 to 4.6 +/- 0.5, p = 0.003 vs. AGA, 4.6 +/- 0.3 to 5.5 +/- 0.4, p = 0.0001). Significant difference was noted for change in FAC (%), FGR 2.1 +/- 1.7 vs. AGA 4.1 +/- 1.2, p = 0.02. Conclusion(s): Differential cardiovascular response to minimally invasive surfactant therapy amongst FGR infants may reflect an in-utero maladaptive state.Copyright © 2020, The Author(s), under exclusive licence to Springer Nature America, Inc. | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1038/s41372-020-0682-5 | PubMed URL: | 32377011 [http://www.ncbi.nlm.nih.gov/pubmed/?term=32377011] | ISSN: | 0743-8346 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/29202 | Type: | Article | Subjects: | newborn prematurity tricuspid annular plane systolic excursion atropine caffeine citrate poractant echocardiograph peripheral venous catheter fractional area change Vivid E95 echocardiography birth weight cardiovascular parameters cardiovascular response fetus gestational age infant intrauterine growth retardation lung hemodynamics minimally invasive procedure |
Type of Clinical Study or Trial: | Observational study (cohort, case-control, cross sectional or survey) |
Appears in Collections: | Articles |
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