Please use this identifier to cite or link to this item:
https://repository.monashhealth.org/monashhealthjspui/handle/1/29335
Title: | Alcohol consumption, cigarette smoking, and risk of breast cancer for BRCA1 and BRCA2 mutation carriers: Results from the BRCA1 and BRCA2 cohort consortium. | Authors: | Walker L.;Li H.;Terry M.B.;Antoniou A.C.;Phillips K.-A.;Kast K.;Mooij T.M.;Engel C.;Nogues C.;Stoppa-Lyonnet D.;Lasset C.;Berthet P.;Mari V.;Caron O.;Barrowdale D.;Frost D.;Brewer C.;Evans D.G.;Izatt L.;Side L.;Tischkowitz M.;Rogers M.T.;Porteous M.E.;Snape K.;Meijers-Heijboer H.E.J.;Gille J.J.P.;Blok M.J.;Hoogerbrugge N.;Daly M.B.;Andrulis I.L.;Buys S.S.;John E.M.;McLachlan S.-A.;Friedlander M.;Tan Y.Y.;Osorio A.;Caldes T.;Jakubowska A.;Simard J.;Singer C.F.;Olah E.;Navratilova M.;Foretova L.;Gerdes A.-M.;Roos-Blom M.-J.;Arver B.;Olsson H.;Schmutzler R.K.;Hopper J.L.;Milne R.L.;Easton D.F.;Van Leeuwen F.E.;Rookus M.A.;Andrieu N.;Goldgar D.E. | Monash Health Department(s): | Monash University - School of Clinical Sciences at Monash Health | Institution: | (Li, Goldgar) Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, United States (Terry) Department of Epidemiology, Columbia University, New York, NY, United States (Terry) Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY, United States (Antoniou, Barrowdale, Frost, Easton) Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, Strangeways Research Laboratory, Worts Causeway, University of Cambridge, Cambridge, United Kingdom (Phillips, Hopper, Milne) Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, VIC, Australia (Phillips) Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Australia (Phillips) Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia (Kast) Department of Gynecology and Obstetrics, Medical Faculty, University Hospital Carl Gustav Carus, Technische Universitat, Dresden, Germany (Kast) National Center for Tumor Diseases (NCT) Partner Site Dresden, Germany (Kast) German Cancer Consortium (DKTK), Dresden and German Cancer Research Center (DKFZ), Heidelberg, Germany (Mooij, Roos-Blom, Van Leeuwen, Rookus) Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, Netherlands (Engel) Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Germany (Nogues) Institut Paoli-Calmettes, Departement d'Anticipation et de Suivi des Cancers, Oncogenetique Clinique and Aix Marseille Univ, INSERM, IRD, SESSTIM, Marseille, France (Stoppa-Lyonnet) Institut Curie, Service de Genetique Medicale, Paris, France (Stoppa-Lyonnet) Inserm, U830, Universite Paris Descartes, Paris, France (Lasset) Unite de Prevention et Epidemiologie Genetique, Centre Leon Berard - Lyon, UMR CNRS 5558, Universite de Lyon, Lyon, France (Berthet) Departement de Biopathologie, Oncogenetique Clinique, Centre Francois Baclesse, Caen, France (Mari) CLCC Antoine Lacassagne, Departement d'Hematologie - Oncologie Medicale, Nice, France (Caron) Departement de Medecine, Gustave Roussy Hopital Universitaire, Villejuif, France (Brewer) Department of Clinical Genetics, Royal Devon and Exeter Hospital, Exeter, United Kingdom (Evans) Genomic Medicine, NIHR Manchester Biomedical Research Centre, Manchester Academic Health Sciences Centre, Division of Evolution and Genomic Sciences, Manchester University, Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom (Izatt) Clinical Genetics, Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom (Side) Wessex Clinical Genetics Service, Princess Anne Hospital, Southampton, United Kingdom (Walker) Oxford Regional Genetics Service, Churchill Hospital, Oxford, United Kingdom (Tischkowitz) University of Cambridge, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cancer Research UK Cambridge Center, Cambridge Biomedical Campus, Cambridge, United Kingdom (Rogers) All Wales Medical Genetics Services, University Hospital of Wales, Cardiff, United Kingdom (Porteous) South East of Scotland Regional Genetics Service, Western General Hospital, Edinburgh, United Kingdom (Snape) Medical Genetics Unit, St. george'S, University of London, London, United Kingdom (Meijers-Heijboer, Gille) Department of Clinical Genetics, VU University Medical Center, Amsterdam, Netherlands (Blok) Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, Netherlands (Hoogerbrugge) Department of Human Genetics, Radboud University Medical Center, Nijmegen, Netherlands (Daly) Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, PA, United States (Andrulis) Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada (Andrulis) Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada (Buys) Department of Medicine, University of Utah Health Sciences Center, Huntsman Cancer Institute, Salt Lake City, UT, United States (John) Stanford University School of Medicine, Department of Medicine, Division of Oncology, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, United States (McLachlan) Department of Medicine, St. Vincent's Hospital, University of Melbourne, Parkville, VIC, Australia (McLachlan) Department of Medical Oncology, St. Vincent's Hospital, Fitzroy, VIC, Australia (Friedlander) Department of Medical Oncology, Prince of Wales Hospital, Randwick, NSW, Australia (Friedlander) Division of Cancer Medicine, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia (Tan, Singer) Department of OB/GYN, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria (Osorio) Human Genetics Group, Spanish National Cancer Centre (CNIO), Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain (Caldes) Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC, CIBERONC (ISCIII), Madrid, Spain (Jakubowska) Department of Genetics and Pathology, Pomeranian Medical University, Unii Lubelskiej 1, Szczecin, Poland (Jakubowska) Independent Laboratory of Molecular Biology and Genetic Diagnostics, Pomeranian Medical University, Szczecin, Poland (Simard) Genomics Center, Centre Hospitalier Universitaire de Quebec, Universite Laval Research Center, Quebec City, QC, Canada (Olah) Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary (Navratilova, Foretova) Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Zluty kopec 7, Brno, Czechia (Gerdes) Department of Oncology and Pathology, Karolinska Institute, Stockholm, Sweden (Arver) Department of Clinical Genetics, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark (Arver, Olsson) Department of Oncology, Lund University Hospital, Lund, Sweden (Schmutzler) Center for Familial Breast and Ovarian Cancer, Center for Integrated Oncology (CIO), Medical Faculty, University Hospital Cologne, Cologne, Germany (Schmutzler) Center for Molecular Medicine Cologne(CMMC), University of Cologne, Cologne, Germany (Milne) Division of Cancer Epidemiology and Intelligence, Cancer Council Victoria, Melbourne, Australia (Milne) Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia (Easton) Centre for Cancer Genetic Epidemiology, Department of Oncology, Strangeways Research Laboratory, Worts Causeway, University of Cambridge, Cambridge, United Kingdom (Andrieu) INSERM, U900, Paris, France (Andrieu) Institut Curie, Paris, France (Andrieu) Mines Paris Tech, Fontainebleau, France (Andrieu) PSL Research University, Paris, France (Goldgar) Department of Dermatology, University of Utah School of Medicine, Salt Lake City, UT, United States (Andrieu) Cancer Genetic Epidemiology Team, INSERM Unit 900, Institut Curie, 26 rue d'Ulm, Paris 75005, France | Issue Date: | 15-Apr-2020 | Copyright year: | 2020 | Publisher: | American Association for Cancer Research Inc. | Place of publication: | United States | Publication information: | Cancer Epidemiology Biomarkers and Prevention. 29 (2) (pp 368-378), 2020. Date of Publication: 01 Feb 2020. | Journal: | Cancer Epidemiology Biomarkers and Prevention | Abstract: | Background: Tobacco smoking and alcohol consumption have been intensively studied in the general population to assess their effects on the risk of breast cancer, but very few studies have examined these effects in BRCA1 and BRCA2 mutation carriers. Given the high breast cancer risk for mutation carriers and the importance of BRCA1 and BRCA2 in DNA repair, better evidence on the associations of these lifestyle factors with breast cancer risk is essential. Method(s): Using a large international pooled cohort of BRCA1 and BRCA2 mutation carriers, we conducted retrospective (5,707 BRCA1 mutation carriers and 3,525 BRCA2 mutation carriers) and prospective (2,276 BRCA1 mutation carriers and 1,610 BRCA2 mutation carriers) analyses of alcohol and tobacco consumption using Cox proportional hazards models. Result(s): For both BRCA1 and BRCA2 mutation carriers, none of the smoking-related variables was associated with breast cancer risk, except smoking for more than 5 years before a first full-term pregnancy (FFTP) when compared with parous women who never smoked. For BRCA1 mutation carriers, the HR from retrospective analysis (HRR) was 1.19 [95% confidence interval (CI), 1.02-1.39] and the HR from prospective analysis (HRP) was 1.36 (95% CI, 0.99-1.87). For BRCA2 mutation carriers, smoking for more than 5 years before an FFTP showed an association of a similar magnitude, but the confidence limits were wider (HRR = 1.25; 95% CI, 1.01-1.55 and HRP = 1.30; 95% CI, 0.83-2.01). For both carrier groups, alcohol consumption was not associated with breast cancer risk. Conclusion(s): The finding that smoking during the prereproductive years increases breast cancer risk for mutation carriers warrants further investigation.Copyright © 2020 American Association for Cancer Research. | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1158/1055-9965.EPI-19-0546 | PubMed URL: | 31792088 [http://www.ncbi.nlm.nih.gov/pubmed/?term=31792088] | ISSN: | 1055-9965 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/29335 | Type: | Article | Subjects: | female *gene mutation hazard ratio heterozygote human pregnancy major clinical study first full term pregnancy *BRCA2 protein/ec [Endogenous Compound] *BRCA1 protein/ec [Endogenous Compound] proportional hazards model priority journal adult *alcohol consumption article *breast cancer *cancer risk *cigarette smoking confidence interval gene mutation hazard ratio heterozygote pregnancy first full term pregnancy BRCA2 protein BRCA1 protein proportional hazards alcohol consumption breast cancer cancer risk cigarette smoking confidence interval Article *breast cancer *cancer risk *cigarette smoking confidence interval female *gene mutation hazard ratio heterozygote human major clinical study pregnancy priority journal proportional hazards model adult *alcohol consumption |
Appears in Collections: | Articles |
Show full item record
Items in Monash Health Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.